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Belumosudil/KD-025

Belumosudil/KD-025 Structure
Belumosudil/KD-025 structure
CAS No.
2109704-99-4
Chemical Name:
Belumosudil/KD-025
Synonyms
Belumosudil mesylate;Belumosudil mesylate (KD025 mesylate);KD025 mesylate;SLx-2119mesylate;Phloroglucinol Impurity 212;2-(3-(4-((1H-indazol-5-yl)amino)quinazolin-2-yl)phenoxy)-N-isopropylacetamide methanesulfonate
CBNumber:
CB89836877
Molecular Formula:
C27H28N6O5S
Molecular Weight:
548.62
MDL Number:
MFCD34470575
MOL File:
2109704-99-4.mol
Last updated:2025-04-18 09:52:57
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Belumosudil/KD-025 Properties

form Solid
color Light yellow to yellow
InChIKey ILQJXEIRBCHLOM-UHFFFAOYSA-N
SMILES S(O)(=O)(=O)C.N(C1=CC=C2NN=CC2=C1)C1=NC(C2C=CC=C(OCC(=O)NC(C)C)C=2)=NC2C=CC=CC1=2
FDA UNII 6MX7XE1M0U

Belumosudil/KD-025 Chemical Properties,Uses,Production

Uses

Belumosudil mesylate (KD025 mesylate) is a selective inhibitor of ROCK2 with IC50s of 105 nM and 24 μM for ROCK2 and ROCK1, respectively. Anti-fibrotic properties[1].

in vivo

Belumosudil (KD-025; 100, 200 or 300 mg/kg, i.p.) dose-dependently reduces infarct volume after transient middle cerebral artery occlusion. Belumosudil is at least as efficacious in aged, diabetic or female mice, as in normal adult males[2].

IC 50

ROCK2: 105 nM (IC50); ROCK1: 24 μM (IC50)

References

[1] Boerma, M., et al. Comparative gene expression profiling in three primary human cell lines after treatment with a novel inhibitor of Rho kinase. Blood Coagul Fibrinolysis. 2008 Oct;19(7):709-18. DOI:10.1097/MBC.0b013e32830b2891
[2] Lee, J.H., et al. Selective ROCK2 Inhibition In Focal Cerebral Ischemia. Ann Clin Transl Neurol. 2014 Jan 1;1(1):2-14. DOI:10.1002/acn3.19

Belumosudil/KD-025 Preparation Products And Raw materials

Raw materials

Preparation Products

Belumosudil/KD-025 Suppliers

Global( 41)Suppliers
Supplier Tel Email Country ProdList Advantage
Moxin Chemicals 		+8617320513646 Anna@molcoo.com China 10586 58
Guangzhou Tosun Pharmaceutical Ltd 		+86-020-61855200-902 +8618124244216 info@upharm.cn China 897 58
Jinan Carbotang Biotech Co.,Ltd. 		+8615866703830 figo.gao@foxmail.com China 8497 58
Wuhan Demeikai Biotechnology Co., Ltd 		+8618942921723 info@dmksw.xin China 717 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38648 58
SUZHOU SENFEIDA CHEMICAL CO.,LTD 		+86-0512-83500002 +8618501500038 3899766280@qq.com China 26362 58
Changzhou AniKare Pharmatech Co., Ltd. 		+86-0519-8359-8696 +8618018249389 sales@anikare.com China 9875 58
Cangzhou Kangrui Pharma Tech Co. Ltd., 		+86-18632776803 +86-13833998158 cangzhoukangrui@126.com China 739 58
Shanghai Massive Chemical Technology Co., Ltd 		+86-021-34943721 +86-18616806816 massive@massivechem.com China 2266 58
Supplier Advantage
Moxin Chemicals 		58
Guangzhou Tosun Pharmaceutical Ltd 		58
Jinan Carbotang Biotech Co.,Ltd. 		58
Wuhan Demeikai Biotechnology Co., Ltd 		58
InvivoChem 		58
TargetMol Chemicals Inc. 		58
SUZHOU SENFEIDA CHEMICAL CO.,LTD 		58
Changzhou AniKare Pharmatech Co., Ltd. 		58
Cangzhou Kangrui Pharma Tech Co. Ltd., 		58
Shanghai Massive Chemical Technology Co., Ltd 		58

View Lastest Price from Belumosudil/KD-025 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Belumosudil mesylate pictures 2025-04-30 Belumosudil mesylate
2109704-99-4
 US $68.00 / mg 98.73% 10g TargetMol Chemicals Inc.
Belumosudil Mesylate pictures 2025-04-29 Belumosudil Mesylate
2109704-99-4
 US $0.00-0.00 / mg 10mg 95%+ 10000000 Moxin Chemicals
Belumosudil mesylate pictures 2025-04-16 Belumosudil mesylate
2109704-99-4
 US $0.00-0.00 / kg 5kg 98%-102% 200 Guangzhou Tosun Pharmaceutical Ltd
KD025 mesylate SLx-2119mesylate Belumosudil mesylate Belumosudil mesylate (KD025 mesylate) 2-(3-(4-((1H-indazol-5-yl)amino)quinazolin-2-yl)phenoxy)-N-isopropylacetamide methanesulfonate Phloroglucinol Impurity 212 2109704-99-4