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Caspofungin

CAS No.
162808-62-0
Chemical Name:
Caspofungin
Synonyms
Caspofungine;Caspofungin (Base);m991;CS-1171;Aids058650;Aids-058650;CASPOFUNGIN;CASPORFUNGIN;Cancidas (tm);Caspofungin MK-0991
CBNumber:
CB91073222
Molecular Formula:
C52H88N10O15
Molecular Weight:
1093.31
MDL Number:
MFCD30541213
MOL File:
162808-62-0.mol
MSDS File:
SDS
Last updated:2024-10-28 23:16:16

Caspofungin Properties

Boiling point 1408.1±65.0 °C(Predicted)
Density 1.36±0.1 g/cm3(Predicted)
pka 9.86±0.26(Predicted)
FDA UNII F0XDI6ZL63
ATC code J02AX04

Pharmacokinetic data

Protein binding 97%
Excreted unchanged in urine 1.4%
Biological half-life 12-15 days / Increased but not significantly. See 'Other information'.

SAFETY

Risk and Safety Statements

Hazardous Substances Data 162808-62-0(Hazardous Substances Data)

Caspofungin price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
American Custom Chemicals Corporation API0005684 CASPOFUNGIN 95.00% 162808-62-0 5MG $495.06 2021-12-16 Buy
Chemenu CM197348 Caspofungine 97% 162808-62-0 1g $729 2021-12-16 Buy
Crysdot CD11242993 Caspofungine 97% 162808-62-0 1g $735 2021-12-16 Buy
AvaChem 3117B Caspofungin 162808-62-0 1g $1390 2021-12-16 Buy
AvaChem 3117B Caspofungin 162808-62-0 5mg $45 2021-12-16 Buy
Product number Packaging Price Buy
API0005684 5MG $495.06 Buy
CM197348 1g $729 Buy
CD11242993 1g $735 Buy
3117B 1g $1390 Buy
3117B 5mg $45 Buy

Caspofungin Chemical Properties,Uses,Production

Method of Administration

After reconstitution and dilution, the solution should be administered by slow intravenous infusion over approximately 1 hour.  Both 70 mg and 50 mg vials are available.   Caspofungin should be given as a single daily infusion.

Uses

Caspofungin is an antifungal drug, and belongs to a new class termed the echinocandins. It is used to treat Aspergillus and Candida infection, and works by inhibiting cell wall synthesis. Antifungals in the echinocandin class inhibit the synthesis of glucan in the cell wall, probably via the enzyme 1,3-beta glucan synthase. There is a potential for resistance development to occur, however in vitro resistance development to Caspofungin by Aspergillus species has not been studied.

Definition

ChEBI: A semisynthetic cyclic hexapeptide echinocandin antibiotic which exerts its effect by inhibiting the synthesis of 1,3-beta-D-glucan, an integral component of the fungal cell wall.

Antimicrobial activity

It is active against Aspergillus spp., Candida spp. and the cyst form of Pn. jirovecii.

Acquired resistance

This is rare, but resistant strains of C. albicans, C. glabrata and C. parapsilosis have been recovered from patients failing caspofungin treatment. These strains are typically cross-resistant to other echinocandins.

Pharmaceutical Applications

A semisynthetic lipopeptide derived from a fermentation product of Glarea lozoyensis. Formulated as the diacetate for intravenous infusion.

Mechanism of action

Caspofungin inhibits the synthesis of beta-(1,3)-D-glucan, an essential component of the cell wall of Aspergillus species and Candida species. beta-(1,3)-D-glucan is not present in mammalian cells. The primary target is beta-(1,3)-glucan synthase.

Pharmacokinetics

Cmax 70 mg 1-h infusion: c. 10 mg/L 1 h post infusion
Plasma half-life: 9–11 h
Volume of distribution: 0.15 L/kg
Plasma protein binding: 97%
Blood concentrations increase in proportion to dosage.
Distribution
The drug is widely distributed, the highest concentrations being found in the liver. Levels in the CSF are negligible.
Metabolism and excretion
It is slowly metabolized by the liver through non-enzymatic peptide hydrolysis and N-acetylation, and the two inactive metabolites are excreted in the feces and bile. No dosage adjustment is required in patients with renal impairment; however, a dose reduction to 35 mg following the 70 mg loading dose is recommended for patients with moderate hepatic impairment. Caspofungin is not cleared by hemodialysis.

Clinical Use

Candidemia and certain invasive forms of candidosis
Esophageal candidosis
Invasive aspergillosis unresponsive to other antifungal drugs
Empirical treatment of presumed fungal infections in febrile neutropenic patients

Side effects

Occasional histamine-mediated infusion-related reactions, injection site reactions and transient abnormalities of liver enzymes have been reported. Rare cases of significant hepatic dysfunction, hepatitis or worsening liver failure have also been described.

Drug interactions

Potentially hazardous interactions with other drugs
Ciclosporin: monitor liver enzymes as transient increases in ALT and AST have been reported with concomitant administration. Avoid coadministration if possible. Increases AUC of caspofungin by 35%.
Tacrolimus: reduces tacrolimus trough concentration by 26%.

Metabolism

Plasma concentrations of caspofungin decline in a polyphasic manner after intravenous infusion. The initial short α-phase occurs immediately post-infusion and is followed by a β-phase with a half-life of 9-11 hours; an additional longer γ-phase also occurs with a half-life of 40-50 hours. Plasma clearance is dependent on distribution rather than on biotransformation or excretion. Caspofungin undergoes spontaneous degradation to an open ring compound. There is further slow metabolism of caspofungin by hydrolysis and N-acetylation and excretion in faeces and urine

Caspofungin Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 149)Suppliers
Supplier Tel Email Country ProdList Advantage
AFINE CHEMICALS LIMITED
+86-0571-85134551 sales@afinechem.com China 15352 58
Hangzhou Hyper Chemicals Limited
+86-0086-57187702781 +8613675893055 info@hyper-chem.com China 295 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21634 55
Xiamen AmoyChem Co., Ltd
+86-86-5926051114 +8618959220845 sales@amoychem.com China 6383 58
BOC Sciences
+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Hubei Ipure Biology Co., Ltd
+8613367258412 ada@ipurechemical.com China 10319 58
Shaanxi Dideu Medichem Co. Ltd
+86-029-89586680 +86-18192503167 1026@dideu.com China 7724 58
Finetech Industry Limited
+86-27-87465837 +8618971612321 info@finetechnology-ind.com China 9639 58
Wuhan Fortuna Chemical Co., Ltd
+86-027-59207850 info@fortunachem.com China 5975 58
Baoji Guokang Healthchem co.,ltd
+8615604608665 15604608665 dominicguo@gk-bio.com CHINA 9414 58

View Lastest Price from Caspofungin manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Caspofungin pictures 2024-12-13 Caspofungin
162808-62-0
US $0.00-0.00 / Kg/Drum 1KG 98%min 500kg WUHAN FORTUNA CHEMICAL CO., LTD
Caspofungin pictures 2024-11-01 Caspofungin
162808-62-0
US $0.00-0.00 / KG 1KG 99% 500KG Hangzhou Hyper Chemicals Limited
Caspofungin pictures 2024-10-28 Caspofungin
162808-62-0
US $2500.00-1980.00 / mg 10g TargetMol Chemicals Inc.
  • Caspofungin pictures
  • Caspofungin
    162808-62-0
  • US $0.00-0.00 / Kg/Drum
  • 98%min
  • WUHAN FORTUNA CHEMICAL CO., LTD
  • Caspofungin pictures
  • Caspofungin
    162808-62-0
  • US $0.00-0.00 / KG
  • 99%
  • Hangzhou Hyper Chemicals Limited
  • Caspofungin pictures
  • Caspofungin
    162808-62-0
  • US $2500.00-1980.00 / mg
  • TargetMol Chemicals Inc.

Caspofungin Spectrum

CASPOFUNGIN CASPORFUNGIN PneuMocandin B0,1-[(4R,5S)-5-[(2-aMinoethyl)aMino]-N2-(10,12-diMethyl-1-oxotetradecyl)-4-hydroxy-L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]- Aids058650 Aids-058650 Cancidas (tm) m991 Caspofungin .CH3COOH (10R,12R)-N-[(3S,6S,9S,11R,15S,18S,20R,21S,24S,25S)-3-[(1R)-3-aMino-1-hydroxypropyl]-21-[(2-aMinoethyl)aMino]-6-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-11,20,25-trihydroxy-15-[(1R)-1-hydroxyethyl]-2,5,8,14,17,23-hexaoxo-1,4,7,13,16,22-hexaazatric CS-1171 Caspofungin MK-0991 Pneumocandin B0, 1-[(4R,5S)-5-[(2-aminoethyl)amino]-N2-[(10R,12S)-10,12-dimethyl-1-oxotetradecyl]-4-hydroxy-L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]- Caspofungin USP/EP/BP Caspofungin diformate salt Caspofungine Caspofungin (Base) 162808-62-0 C52H88N10O15 C53H89N9O15 Antifungals