ChemicalBook >> CAS DataBase List >>AZ5576
AZ5576
- CAS No.
- 2751721-40-9
- Chemical Name:
- AZ5576
- Synonyms
- AZ5576;Cyclohexanecarboxamide, 3-(acetylamino)-N-[4-(4-fluoro-2-methoxyphenyl)-2-pyridinyl]-, (1S,3R)-
- CBNumber:
- CB911029851
- Molecular Formula:
- C21H24FN3O3
- Molecular Weight:
- 385.43
- MDL Number:
- MOL File:
- 2751721-40-9.mol
Last updated:2024-07-02 08:55:39
AZ5576 Chemical Properties,Uses,Production
Description
AZ5576 is a potent and highly selective CDK9 inhibitor. Treatment with AZ5576 inhibited growth of DLBCL cell lines in vitro and in vivo, independent of cell-of-origin. CDK9 inhibition downregulated Mcl-1 and MYC mRNA transcript and protein in a dose-dependent manner. MYC-expressing cell lines demonstrated enhanced susceptibility to AZ5576. CDK9 inhibition promoted turnover of MYC protein, and decreased MYC phosphorylation at the stabilizing Ser62 residue and downregulated MYC transcriptional targets in DLBCL cells, a finding confirmed in a functional reporter assay, suggesting that CDK9 may govern MYC protein turnover, thus regulating its expression through multiple mechanisms.
AZ5576 Preparation Products And Raw materials
Raw materials
Preparation Products
AZ5576 Suppliers
Global( 11)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3466 | 58 |
ATK CHEMICAL COMPANY LIMITED | 3429815786 13301662590 | sales@atkchemical.com | China | 9994 | 55 |
Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9949 | 58 |
DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9412 | 58 |
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd | 15317229551 | 15151849396@163.com | China | 996 | 58 |
TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24647 | 58 |
Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11975 | 58 |
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd | 021-59167510 18117107507 | vip@med-life.cn | China | 5012 | 58 |
AZ5576
Cyclohexanecarboxamide, 3-(acetylamino)-N-[4-(4-fluoro-2-methoxyphenyl)-2-pyridinyl]-, (1S,3R)-
2751721-40-9