Bindarit
- CAS No.
- 130641-38-2
- Chemical Name:
- Bindarit
- Synonyms
- AF 2838;CS-1989;indarit;Bindarit;Bindarit (AF2838);AF2838;AF-2838;AF 2838;Bindarit, CCL2, CCL7 and CCL8 inhibitor;2-[(1-benzylindazol-3-yl)methoxy]-2-methylpropanoic acid;2-((1-Benzyl-1H-indazol-3-yl)Methoxy)-2-Methylpropanoic acid;2-[(1-Benzyl-1H-indazol-3-yl)methoxy]-2-methylpropionic acid
- CBNumber:
- CB91118288
- Molecular Formula:
- C19H20N2O3
- Molecular Weight:
- 324.37
- MDL Number:
- MFCD00866723
- MOL File:
- 130641-38-2.mol
- MSDS File:
- SDS
| Boiling point | 542.9±40.0 °C(Predicted) |
|---|---|
| Density | 1.18±0.1 g/cm3 (20 ºC 760 Torr) |
| storage temp. | 2-8°C |
| solubility | DMSO:47.0(Max Conc. mg/mL);144.89(Max Conc. mM) |
| form | A crystalline solid |
| pka | 3.59±0.10(Predicted) |
| color | White to off-white |
| FDA UNII | JQ11LH711M |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| NFPA 704 |
|
Bindarit price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 11479 | Bindarit ≥98% | 130641-38-2 | 1mg | $25 | 2024-03-01 | Buy |
| Cayman Chemical | 11479 | Bindarit ≥98% | 130641-38-2 | 5mg | $88 | 2024-03-01 | Buy |
| Cayman Chemical | 11479 | Bindarit ≥98% | 130641-38-2 | 10mg | $150 | 2024-03-01 | Buy |
| Cayman Chemical | 11479 | Bindarit ≥98% | 130641-38-2 | 25mg | $250 | 2024-03-01 | Buy |
| Usbiological | 003975 | Bindarit | 130641-38-2 | 5mg | $460 | 2021-12-16 | Buy |
Bindarit Chemical Properties,Uses,Production
Description
Bindarit is an inhibitor of monocyte chemoattractant protein (MCP) production that is selective for MCP-1/CCL2, MPC-3/CCL7, and MCP-2/CCL8 over other chemokines. It inhibits LPS- or C. albicans-induced production of MCP-1/CCL2 in isolated human monocytes (IC50s = 172 and 403 μM, respectively). Bindarit downregulates NF-κB signaling and prevents p65 and p65/p50-mediated MCP-1/CCL2 promoter activation in RAW264.7 cells. It delays the onset of proteinuria and prolongs survival in a mouse model of experimental lupus nephritis when administered at a dose of 50 mg/kg. It prevents LPS-induced increases in MCP-1/CCL2 expression in mouse brain and spinal cord when administered at a dose of 200 mg/kg and reduces the incidence and severity of experimental autoimmune encephalomyelitis (EAE) in mice. Bindarit is also a noncompetitive inhibitor of monocarboxylate transporter 4 (MCT4; Ki = 30.2 μM for the human transporter) that is selective for MCT4 over MCT1.
Uses
Bindarit shows anti-inflammatory activity due to a selective inhibition of a subfamily of inflammatory chemokines. Bindarit is a also protein antidenaturant agent. Bindarit modulates the NFkB pathway and has been shown to reduce secondary phase of adjuvant arthritis in rats.
Uses
Bindarit exhibits selective inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8.
Bindarit Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Synchem Pharma Co., Ltd | +86-61984905-1 +86-18016477331 | synchempharma@aliyun.com | China | 92 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32956 | 60 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 965 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19908 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |