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ChemicalBook >> CAS DataBase List >>Butanoic acid, 2-[[6-[[3'-(aminomethyl)[1,1'-biphenyl]-3-yl]oxy]-3,5-difluoro-2-pyridinyl]oxy]-, hydrochloride (1:1), (2R)-

Butanoic acid, 2-[[6-[[3'-(aminomethyl)[1,1'-biphenyl]-3-yl]oxy]-3,5-difluoro-2-pyridinyl]oxy]-, hydrochloride (1:1), (2R)-

Butanoic acid, 2-[[6-[[3'-(aminomethyl)[1,1'-biphenyl]-3-yl]oxy]-3,5-difluoro-2-pyridinyl]oxy]-, hydrochloride (1:1), (2R)- Structure
Butanoic acid, 2-[[6-[[3'-(aminomethyl)[1,1'-biphenyl]-3-yl]oxy]-3,5-difluoro-2-pyridinyl]oxy]-, hydrochloride (1:1), (2R)- structure
CAS No.
2629177-12-2
Chemical Name:
Butanoic acid, 2-[[6-[[3'-(aminomethyl)[1,1'-biphenyl]-3-yl]oxy]-3,5-difluoro-2-pyridinyl]oxy]-, hydrochloride (1:1), (2R)-
Synonyms
ZK824190 hydrochloride;Butanoic acid, 2-[[6-[[3'-(aminomethyl)[1,1'-biphenyl]-3-yl]oxy]-3,5-difluoro-2-pyridinyl]oxy]-, hydrochloride (1:1), (2R)-
CBNumber:
CB912138154
Molecular Formula:
C22H21ClF2N2O4
Molecular Weight:
450.87
MDL Number:
MOL File:
2629177-12-2.mol
Last updated:2024-10-23 13:36:13
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Butanoic acid, 2-[[6-[[3'-(aminomethyl)[1,1'-biphenyl]-3-yl]oxy]-3,5-difluoro-2-pyridinyl]oxy]-, hydrochloride (1:1), (2R)- Properties

storage temp. 4°C, protect from light
form Solid
color White to off-white

Butanoic acid, 2-[[6-[[3'-(aminomethyl)[1,1'-biphenyl]-3-yl]oxy]-3,5-difluoro-2-pyridinyl]oxy]-, hydrochloride (1:1), (2R)- Chemical Properties,Uses,Production

Biological Activity

ZK824190 hydrochloride is an orally available and selective urokinase plasminogen activator (uPA) inhibitor as a potential treatment for multiple sclerosis. IC50s of 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively[1]. ZK824190 (2 mg/kg; PO; Rats with EAE model) exhibits a relatively high oral availability and a moderate half time (T1/2=2.8 h)[1].

References

[1]. Islam I, et al. Discovery of selective urokinase plasminogen activator (uPA) inhibitors as a potential treatment for multiple sclerosis. Bioorg Med Chem Lett. 2018 Nov 1;28(20):3372-3375.

Butanoic acid, 2-[[6-[[3'-(aminomethyl)[1,1'-biphenyl]-3-yl]oxy]-3,5-difluoro-2-pyridinyl]oxy]-, hydrochloride (1:1), (2R)- Preparation Products And Raw materials

Raw materials

Preparation Products

Butanoic acid, 2-[[6-[[3'-(aminomethyl)[1,1'-biphenyl]-3-yl]oxy]-3,5-difluoro-2-pyridinyl]oxy]-, hydrochloride (1:1), (2R)- Suppliers

Global( 3)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+8613564774135 zijue.cai@tsbiochem.com United States 19863 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11974 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 19711 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Shanghai Yifei Biotechnology Co. , Ltd. 58
TargetMol Chemicals Inc. 58

View Lastest Price from Butanoic acid, 2-[[6-[[3'-(aminomethyl)[1,1'-biphenyl]-3-yl]oxy]-3,5-difluoro-2-pyridinyl]oxy]-, hydrochloride (1:1), (2R)- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
ZK824190 hydrochloride pictures 2024-10-24 ZK824190 hydrochloride
2629177-12-2
 US $1780.00-2690.00 / mg 10g TargetMol Chemicals Inc.
Butanoic acid, 2-[[6-[[3'-(aminomethyl)[1,1'-biphenyl]-3-yl]oxy]-3,5-difluoro-2-pyridinyl]oxy]-, hydrochloride (1:1), (2R)- ZK824190 hydrochloride 2629177-12-2