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Description

11β-Prostaglandin F_2α-d₉ (11β-PGF_2α-d₉) is intended for use as an internal standard for the quantification of 11β-PGF_2α by GC- or LC-MS. 11β-PGF_2α is the primary metabolite of PGD₂ .¹ It is formed from PGD₂ via the NADPH-dependent aldo-keto reductase PGF synthase (PGFS; ） in the liver or lung.² 11β-PGF_2α induces contraction of isolated cat iris sphincter, which endogenously expresses high levels of PGF_2α (FP) receptors, with an EC₅₀ value of 0.045 μM.¹ It also induces contraction of isolated human bronchial smooth muscle when used at concentrations ranging from 0.1 to 30 μM.³ 11β-PGF_2α (0.1 and 1 μM) induces phosphorylation of ERK and CREB, as well as increases the viability of MCF-7 breast cancer cells stably expressing the FP receptor when used at concentrations of 0.1 and 1 μM.⁴

Uses

9α,11β-Prostaglandin F2α-d9 is the deuterium labeled 9α,11β-Prostaglandin F2α[1].

References

1. Giles, H., Bolofo, M.L., Lydford, S.J., et al. A comparative study of the prostanoid receptor profile of 9α 11 β-prostaglandin F2 and prostaglandin D₂ Br. J. Pharmacol. 104(2),541-549(1991).
2. Watanabe, K. Prostaglandin F synthase Prostaglandins Other Lipid Mediat. 68-69,401-407(2002).
3. Coleman, R.A., and Sheldrick, R.L.G. Prostanoid-induced contraction of human bronchial smooth muscle is mediated by TP-receptors Br. J. Pharmacol. 96(3),688-692(1989).
4. Yoda, T., Kikuchi, K., Miki, Y., et al. 11β-Prostaglandin F_2α, a bioactive metabolite catalyzed by AKR1C3, stimulates prostaglandin F receptor and induces slug expression in breast cancer Mol. Cell. Endocrinol. 413,236-247(2015).

Raw materials

Preparation Products