igmesine
- CAS No.
- 130152-35-1
- Chemical Name:
- igmesine
- Synonyms
- -ethyl-N-methyl-α(+)-Igmesine hydrochloride;(+)-IgMesine hydrochloride;Cinnamyl-1-phenyl-1-N-methyl-N-cyclopropylene;-(3-phenyl-2-propenyl)-benzenemethanamineHydrochloride;(+)-alpha-(E)-Cinnamyl)-N-(cyclopropylmethyl)-alpha-ethyl-N-methylbenzylamine;N-(1,4-diphenyl-1-ethyl-3-buten-1-yl)-N-methyl-cyclopropanemethanamine hydrochloride;(E)-(+)-N-(Cyclopropylmethyl)-α-ethyl-N-methyl-α-(3-phenyl-2-propenyl)-benzenemethanamine Hydrochloride;(R)-(+)-N-Cyclopropylmethyl-α-ethyl-N-methyl-α-[(2E)-3-phenyl-2-propenyl)benzenemethanamine hydrochloride;Benzenemethamine, N-(cyclopropylmethyl)-alpha-ethyl-N-methyl-alpha-(3-phenyl-2-propenyl)-, hydrochloride, (+)-
- CBNumber:
- CB91326689
- Molecular Formula:
- C23H30ClN
- Molecular Weight:
- 355.95
- MDL Number:
- MFCD00911707
- MOL File:
- 130152-35-1.mol
- MSDS File:
- SDS
| storage temp. | Store at -20°C |
|---|---|
| solubility | <17.8mg/ml in DMSO |
| form | solid |
| color | White |
| FDA UNII | JV6M14TY35 |
igmesine price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 2332 | (+)-Igmesinehydrochloride ≥98%(HPLC) | 130152-35-1 | 10 | $293 | 2021-12-16 | Buy |
| Tocris | 2332 | (+)-Igmesinehydrochloride ≥98%(HPLC) | 130152-35-1 | 50 | $1178 | 2021-12-16 | Buy |
| TRC | C990050 | (E)-(+)-N-(Cyclopropylmethyl)-α-ethyl-N-methyl-α-(3-phenyl-2-propenyl)-benzenemethanamineHydrochloride | 130152-35-1 | 10mg | $250 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0010428 | (R)-(+)-N-CYCLOPROPYLMETHYL-ALPHA-ETHYL-N-METHYL-ALPHA-[(2E)-3-PHENYL-2-PROPENYL)BENZENEMETHANAMINE HYDROCHLORIDE 95.00% | 130152-35-1 | 50MG | $1565.03 | 2021-12-16 | Buy |
| ApexBio Technology | B5294 | (+)-Igmesinehydrochloride | 130152-35-1 | 50mg | $1746 | 2021-12-16 | Buy |
igmesine Chemical Properties,Uses,Production
Uses
(E)-(+)-N-(Cyclopropylmethyl)-α-ethyl-N-methyl-α-(3-phenyl-2-propenyl)-benzenemethanamine Hydrochloride is a sigma receptor agonist. Sigma receptors are non-opioid receptors that bind a wide range of psychotropic compounds. (E)-(+)-N-(Cyclopropylmethyl)-α-ethyl-N-methyl-α-(3-phenyl-2-propenyl)-benzenemethanamine Hydrochloride is a neuroprotective and an antidepressant agent.
Uses
Antidepressant (sigma receptor ligand).
Biological Activity
jo 1784 is a selective σ1 receptor ligand.the cns σ receptor ligands, as is known, modulates central neurotransmitter systems ( noradrenergic-, glutaminergic-, and dopaminergic-neurons was included).
in vitro
compared with control, data obtained displayed significant reduction in the densities of β-adrenergic, but not σ1, 5-ht1a, and gabab receptors in fluoxetine (18%), desipramine (dmi, 32%) and jo 1784 (20%)-treated groups. tyrosine hydroxylase (th) activity was significantly (30–32%) decreased in all treated groups. further, fluoxetine and dmi excluding the jo 1784 -treated groups diaplayed 85 and 40% reductions in serotonin (5-ht) and noradrenaline (ne) neuronal uptake, respectively. following acute treatment, jo 1784 is inactive for monoamine oxidase (mao) a or b [1].
in vivo
in vivo studies, jo 1784 at behaviorally active doses exhibited weak effects on the ne uptake but has no activity in altering 5-ht and da synthesis or antagonizing selective drug-stimulated depletion of monoamine neuronal uptake. nmda-induced potentiates cgmp was inhibited by jo 1784, indicating that jo 1784 may interfere with the nmda receptor/nos/cgmp pathway. although it appears that the pharmacological actions of jo 1784 partially is modulated by the monoaminergic system, there is still need to find other possible mechanisms of antidepressant action [1].
IC 50
19.1 nm
storage
Store at -20°C
References
[1]. akunne hc, zoski kt, whetzel sz, cordon jj, brandon rm, roman f, pugsley ta. neuropharmacological profile of a selective sigma ligand, igmesine: a potential antidepressant. neuropharmacology. 2001 jul;41(1):138-49.
igmesine Preparation Products And Raw materials
Raw materials
Preparation Products
igmesine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21638 | 55 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52925 | 58 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8447 | 60 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44808 | 58 |
| Henan Alpha Chemical Co., Ltd. | 0371-55013243 15324716602 | 2853979810@qq.com | China | 9999 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 4870 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 18112977050 | cb5@aikonchem.com | China | 10528 | 58 |
| Shanghai Chengrui Biotechnology Co., Ltd | 15316859367 | 2472126714@qq.com | China | 312 | 58 |
| ApexBio Technology | -- | sales@apexbt.com | United States | 6251 | 58 |