escin Ia
- CAS No.
- Chemical Name:
- escin Ia
- Synonyms
- escin Ia
- CBNumber:
- CB91361055
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
escin Ia Chemical Properties,Uses,Production
Bioactivities
Escin IA is a triterpene saponin isolated from horse chestnut, which inhibits HIV-1 protease with IC50 values of 35 μM. Escin IA has anti-TNBC metastasis activity, and its action mechanisms involved inhibition of epithelial-mesenchymal transition process by down-regulating LOXL2 expression.
Pharmacology
The saponin fraction of Aesculus chinensis Bunge fruits (SFAC) could inhibit the invasion and migration of MDA-MB-231 cells. Among which, Escin IA showed more potent inhibition of the invasion than other five main saponin constituents. It selectively reduced the expression of LOXL2 mRNA and promoted the expression of E-cadherin mRNA, and prevented the EMT process of MDA-MB-231 cells and TNF-α/TGF-β-stimulated MCF-7 cells. Moreover, it reduced the LOXL2 level in MDA-MB-231 cells but not in MCF-7 cells. When MCF-7 cells were stimulated with TNF-α/TGF-β, transfected with LOXL2 or treated with hypoxia, Escin IA down-regulated the level of LOXL2 in MCF-7 cells. Meanwhile, Escin IA suppressed the EMT process in LOXL2-transfected or hypoxia-treated MCF-7 cells. Of interest, Escin IA did not alter the level of HIF-1α in hypoxia-induced MCF-7 cells.In TNBC xenograft mice, the metastasis and EMT of MDA-MB-231 cells were suppressed by Escin IA.
escin Ia Preparation Products And Raw materials
Raw materials
Preparation Products
escin Ia Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| United States Biological | -- | chemicals@usbio.net | United States | 6214 | 80 |
| Guangzhou Weijia Technology Co., Ltd. | -- | WHIGA22@126.COM | CHINA | 6748 | 58 |
| Shanghai Yaji Biotechnology Co., Ltd. | -- | CHINA | 6857 | 58 | |
| Shanghai Caiyou Industrial Co., Ltd. | -- | 15821073967@163.com | CHINA | 6893 | 58 |
| Absin Bioscience Inc. | -- | chenjw@absin.cn | CHINA | 6654 | 58 |
| Shanghai Yijie Biological Technology Co., Ltd. | -- | SHYIJIEBIO@126.COM | CHINA | 3510 | 58 |
| Shanghai Yanmu Industrial Co., Ltd. | -- | 2095001174@qq.com | CHINA | 6722 | 58 |
| Shanghai yiji industries Co., Ltd. | -- | yiji01@foxmail.com | China | 6289 | 50 |
| Beijing Shengke Boyuan Biotechnology Co., Ltd. | -- | 978560024@qq.com | CHINA | 6005 | 58 |
| Shanghai Weiwei Biological Technology Co., Ltd. | -- | sales@wheybio.com | CHINA | 4398 | 58 |
Related articles
- What is Escin IA?
- Escin IA is a triterpene saponin isolated from horse chestnut, which inhibits HIV-1 protease with IC50 values of 35 μM. Escin ....
- Feb 13，2020