Licofelone
- CAS No.
- 156897-06-2
- Chemical Name:
- Licofelone
- Synonyms
- icofeL;ML 3000;Licofelone;Licofelone, >=99%;Licofelone, ML-3000;Licofelone USP/EP/BP;16-dihydrotanshinone I;2-[2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-5,7-dihydropyrrolizin-3-yl]acetic acid;1H-Pyrrolizine-5-aceticacid, 6-(4-chlorophenyl)-2,3-dihydro-2,2-diMethyl-7-phenyl-;6-(4-Chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl- 1H-pyrrolizine-5-acetic Acid
- CBNumber:
- CB91385206
- Molecular Formula:
- C23H22ClNO2
- Molecular Weight:
- 379.88
- MDL Number:
- MFCD00929900
- MOL File:
- 156897-06-2.mol
- MSDS File:
- SDS
Melting point | 162-163°C |
---|---|
Boiling point | 539.7±50.0 °C(Predicted) |
Density | 1.23 |
storage temp. | -20°C Freezer |
solubility | Chloroform, Methanol |
pka | 4.47±0.10(Predicted) |
form | Solid |
color | Off-White to Light Yellow |
CAS DataBase Reference | 156897-06-2(CAS DataBase Reference) |
FDA UNII | P5T6BYS22Y |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H319 |
Precautionary statements | P305+P351+P338 |
Licofelone price More Price(25)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 10007692 | Licofelone ≥98% | 156897-06-2 | 1mg | $55 | 2024-03-01 | Buy |
Cayman Chemical | 10007692 | Licofelone ≥98% | 156897-06-2 | 5mg | $158 | 2024-03-01 | Buy |
Cayman Chemical | 10007692 | Licofelone ≥98% | 156897-06-2 | 10mg | $289 | 2024-03-01 | Buy |
Cayman Chemical | 10007692 | Licofelone ≥98% | 156897-06-2 | 50mg | $1305 | 2024-03-01 | Buy |
TRC | L397730 | Licofelone | 156897-06-2 | 1mg | $50 | 2021-12-16 | Buy |
Licofelone Chemical Properties,Uses,Production
Description
Cross-
Chemical Properties
Yellowish Solid
Uses
Dual inhibitor of cyclooxygenase and 5-lipoxygenase. Anti-inflammatory.
in vitro
the 5-lox and cox inhibitory effect of licofelone was firstly identified via bovine thromobocyte intact cell assay and intact bovine pmn leukocytes. licofelone was also reported to inhibit pge2 in a dose-dependent manner in human whole blood assay. moreover, licofelone was found to suppress in vitro generation of reactive oxygen species and to reduce release of elastase from pmn leukocytes. all above findings revealed that licofelone had an inhibitory effect on cox-1/-2 and 5-lox. [1]
in vivo
the pharmacodynamic properties of licofelone were evaluated in various animal models and compared with those of commonly used nsaids. based on studies from a rat model of incisional pain, orally administration of licofelone had a longer duration of action and was more effective than indomethacin and zileuton. [1]
IC 50
inhibitor of cox-1, cox-2 and 5-lox with ic50 values of 0.16 m, 0.37 m and 0.23 m respectively in human.
References
[1]kulkarni sk and singh vp. licofelone-a novel analgesic and anti-inflammatory agent. curr top med chem. 2007; 7(3): 251-63.
Licofelone Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21663 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9284 | 55 |
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49392 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29821 | 58 |
Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10326 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 23499 | 58 |
AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15386 | 58 |
Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9640 | 58 |
Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9923 | 58 |
View Lastest Price from Licofelone manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2021-07-02 | Licofelone
156897-06-2
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | ||
2020-01-19 | Licofelone
156897-06-2
|
US $3.00 / KG | 1KG | 99% | 1kg,5kg,50kg | Career Henan Chemical Co |
- Licofelone
156897-06-2
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
- Licofelone
156897-06-2
- US $3.00 / KG
- 99%
- Career Henan Chemical Co
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