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CI 934

CI 934 Structure
CI 934 structure
CAS No.
91188-00-0
Chemical Name:
CI 934
Synonyms
CI 934;PD-114843;Aids007688;Aids-007688;Quinolone cl-934;Merafloxacin (CI-934);Merafloxacin, 10 mM in DMSO;1-Ethyl-7-(3-((ethylamino)methyl)pyrrolidin-1-yl)-6,8-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid;1-Ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid;3-Quinolinecarboxylic acid, 1-ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4-dihydro-4-oxo-
CBNumber:
CB91398664
Molecular Formula:
C19H23F2N3O3
Molecular Weight:
379.4
MDL Number:
MOL File:
91188-00-0.mol
Last updated:2025-04-17 18:22:24
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CI 934 Properties

Melting point 200-220.45 °C
Boiling point 545.8±50.0 °C(Predicted)
Density 1.304±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 11.11 mg/mL (29.28 mM; ultrasonic and adjust pH to 3 with HCl)
form Solid
pka 6.44±0.50(Predicted)
color White to off-white

CI 934 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Adipogen Life Sciences AG-CR1-3756-M005 Merafloxacin ≥95% 91188-00-0 5mg $80 2021-12-16 Buy
Product number Packaging Price Buy
AG-CR1-3756-M005 5mg $80 Buy

CI 934 Chemical Properties,Uses,Production

Uses

Merafloxacin (CI-934), a fluoroquinolone antibacterial agent, is a selective programmed -1 ribosomal frameshifting (-1 PRF) inhibitor of beta coronaviruses. Merafloxacin exhibits in vitro activity against gram-positive and gram-negative bacteria[1][2].

Biological Activity

Merafloxacin (CI-934), a fluoroquinolone antibacterial agent, is a selective programmed -1 ribosomal frameshifting (-1 PRF) inhibitor of beta coronaviruses. Merafloxacin exhibits in vitro activity against gram-positive and gram-negative bacteria[1][2]. Merafloxacin (5-80 μM) dose-dependently inhibits programmed -1 ribosomal frameshifting (-1 PRF) of SARS-CoV-2, SARS-CoV, hCoVO-C43, and hCoV-HKU1, with IC50s of 19.6 μM, 19.5 μM, 29.7 μM, and 38.6 μM, respectively[1].

References

[1]. Sun Y, et, al. Restriction of SARS-CoV-2 Replication by Targeting Programmed -1 Ribosomal Frameshifting In Vitro. bioRxiv. 2020 Oct 21;2020.10.21.349225. [2]. Mandell W, et, al. In vitro activity of CI-934, a new quinolone, compared with that of other quinolones and other antimicrobial agents. Antimicrob Agents Chemother. 1986 May;29(5):852-7.

CI 934 Preparation Products And Raw materials

Raw materials

Preparation Products

CI 934 Suppliers

Global( 34)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32159 58
Shenzhen Shengda Pharma Limited 		755-85269922 +8613424394241 sales@shengdapharm.com CHINA 310 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581 sales@chemhifuture.com China 3135 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38630 58
LEAPCHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 43340 58
Aladdin Scientific 		tp@aladdinsci.com United States 52924 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185 sales-cpd@caerulumpharma.com China 3466 58
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9803 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
TargetMol Chemicals Inc. 		58
Shenzhen Shengda Pharma Limited 		58
InvivoChem 		58
Nantong HI-FUTURE Biology Co., Ltd. 		58
TargetMol Chemicals Inc. 		58
LEAPCHEM CO., LTD. 		58
Aladdin Scientific 		58
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
Shanghai EFE Biological Technology Co., Ltd. 58

View Lastest Price from CI 934 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Merafloxacin pictures 2024-11-19 Merafloxacin
91188-00-0
 US $56.00-122.00 / mg 97.57% 10g TargetMol Chemicals Inc.
  • Merafloxacin pictures
  • Merafloxacin
    91188-00-0
  • US $56.00-122.00 / mg
  • 97.57%
  • TargetMol Chemicals Inc.
CI 934 1-Ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid PD-114843 Aids007688 Aids-007688 Quinolone cl-934 3-Quinolinecarboxylic acid, 1-ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4-dihydro-4-oxo- Merafloxacin (CI-934) Merafloxacin,frameshifting,SARS-CoV,bacteria,antibacterial,fluoroquinolone,Inhibitor,CI934,gram-positive,inhibit,programmed,coronaviruses,ribosomal,PRF,gram-negative,SARS coronavirus,CI-934 1-Ethyl-7-(3-((ethylamino)methyl)pyrrolidin-1-yl)-6,8-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid Merafloxacin, 10 mM in DMSO 91188-00-0