ChemicalBook >> CAS DataBase List >>(1R,3S)-5-[2-[(1R,3aR,7aS)-1-[(2R,5S)-5-hydroxy-6-methyl-heptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol

(1R,3S)-5-[2-[(1R,3aR,7aS)-1-[(2R,5S)-5-hydroxy-6-methyl-heptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol

CAS No.
93129-94-3
Chemical Name:
(1R,3S)-5-[2-[(1R,3aR,7aS)-1-[(2R,5S)-5-hydroxy-6-methyl-heptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol
Synonyms
CB91456900;Tacalcitol monohydrate;24(R)-Dihydroxyvitamin D3;1,24-dihydroxy Vitamin D3 (hydrate);24(R)-Dihydroxyvitamin D3 monohydrate;1,24(R)-DihydroxyvitaMin D3, Monohydrate;1-alpha,24(R)-Dihydroxyvitamin D3 monohydrate;9,10-Secocholesta-5,7,10(19)-triene-1,3,24-triol,Monohydrate, (1a,3b,5Z,7E,24R)- (9CI);(1R,3S)-5-[2-[(1R,3aR,7aS)-1-[(2R,5S)-5-hydroxy-6-Methyl-heptan-2-yl]-7a-Methyl-2,3,3a,5,6,7-hexahyd;Curatoderm monohydrate|||TV 02 monohydrate|||TV-02H monohydrate|||1,24(R)-Dihydroxyvitamin D3 monohydrate
CBNumber:
CB91456900
Molecular Formula:
C27H46O4
Molecular Weight:
434.66
MDL Number:
MFCD13184757
MOL File:
93129-94-3.mol
MSDS File:
SDS
Last updated:2023-06-08 09:02:10

(1R,3S)-5-[2-[(1R,3aR,7aS)-1-[(2R,5S)-5-hydroxy-6-methyl-heptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol Properties

storage temp. Store at -20°C
solubility DMSO
form Powder
Stability Light Sensitive
FDA UNII B3Q63NVN9R

(1R,3S)-5-[2-[(1R,3aR,7aS)-1-[(2R,5S)-5-hydroxy-6-methyl-heptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 12079 1,24-dihydroxy Vitamin D3 (hydrate) ≥98% 93129-94-3 500μg $97 2024-03-01 Buy
Cayman Chemical 12079 1,24-dihydroxy Vitamin D3 (hydrate) ≥98% 93129-94-3 1mg $145 2024-03-01 Buy
Cayman Chemical 12079 1,24-dihydroxy Vitamin D3 (hydrate) ≥98% 93129-94-3 5mg $337 2024-03-01 Buy
TRC T004050 TacalcitolMonohydrate 93129-94-3 25mg $1125 2021-12-16 Buy
Medical Isotopes, Inc. 33768 TacalcitolMonohydrate 93129-94-3 5mg $1225 2021-12-16 Buy
Product number Packaging Price Buy
12079 500μg $97 Buy
12079 1mg $145 Buy
12079 5mg $337 Buy
T004050 25mg $1125 Buy
33768 5mg $1225 Buy

(1R,3S)-5-[2-[(1R,3aR,7aS)-1-[(2R,5S)-5-hydroxy-6-methyl-heptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol Chemical Properties,Uses,Production

Description

Vitamin D aids in the absorption of calcium and has central roles in bone formation and maintenance, hypertension, cancer, and immunity. In addition, the active form of vitamin D, 1,25-dihydroxy vitamin D3, decreases the proliferation and increases differentiation of keratinocytes. 1,24-dihydroxy Vitamin D3 is an analog of 1,25-dihydroxy vitamin D3 which, when used in a 4 μg/g ointment, safely and effectively suppresses psoriasis. It also is effective at increasing the time interval between phototherapy cycles when ultraviolet light is used for psoriasis. 1,24-dihydroxy Vitamin D3 inhibits the growth of both normal and psoriatic human keratinocytes (IC50 ~ 10 nM) via the vitamin D receptor. It also suppresses the production of RANTES and IL-8 by human dermal fibroblasts and reduces cutaneous lymphocyte-associated antigen on CD4+ T cells, impairing migration and skin infiltration.

Uses

Tacalcitol Monohydrate is used as a vitamin D analog used in combination with Imatinib (G407000) in the therapy of non-small cell lung cancer. It is a COVID19-related research product.

(1R,3S)-5-[2-[(1R,3aR,7aS)-1-[(2R,5S)-5-hydroxy-6-methyl-heptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol Preparation Products And Raw materials

Raw materials

Preparation Products

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93129-94-3((1R,3S)-5-[2-[(1R,3aR,7aS)-1-[(2R,5S)-5-hydroxy-6-methyl-heptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol)Related Search:

(1R,3S)-5-[2-[(1R,3aR,7aS)-1-[(2R,5S)-5-hydroxy-6-methyl-heptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol 1,24(R)-DihydroxyvitaMin D3, Monohydrate (1R,3S)-5-[2-[(1R,3aR,7aS)-1-[(2R,5S)-5-hydroxy-6-Methyl-heptan-2-yl]-7a-Methyl-2,3,3a,5,6,7-hexahyd 9,10-Secocholesta-5,7,10(19)-triene-1,3,24-triol,Monohydrate, (1a,3b,5Z,7E,24R)- (9CI) 1-alpha,24(R)-Dihydroxyvitamin D3 monohydrate Tacalcitol monohydrate 1,3-Cyclohexanediol, 4-methylene-5-[(2E)-2-[(1R,3aS,7aR)-octahydro-1-[(1R,4R)-4-hydroxy-1,5-dimethylhexyl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-, hydrate , (1R,3S,5Z)- 24(R)-Dihydroxyvitamin D3 1,24-dihydroxy Vitamin D3 (hydrate) 24(R)-Dihydroxyvitamin D3 monohydrate 1,3-Cyclohexanediol, 4-methylene-5-[(2E)-2-[(1R,3aS,7aR)-octahydro-1-[(1R,4R)-4-hydroxy-1,5-dimethylhexyl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-, hydrate (1:1), (1R,3S,5Z)- CB91456900 Curatoderm monohydrate|||TV 02 monohydrate|||TV-02H monohydrate|||1,24(R)-Dihydroxyvitamin D3 monohydrate 93129-94-3