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ChemicalBook >> CAS DataBase List >>(1R,3S)-5-[2-[(1R,3aR,7aS)-1-[(2R,5S)-5-hydroxy-6-methyl-heptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol

(1R,3S)-5-[2-[(1R,3aR,7aS)-1-[(2R,5S)-5-hydroxy-6-methyl-heptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol

(1R,3S)-5-[2-[(1R,3aR,7aS)-1-[(2R,5S)-5-hydroxy-6-methyl-heptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol Structure
(1R,3S)-5-[2-[(1R,3aR,7aS)-1-[(2R,5S)-5-hydroxy-6-methyl-heptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol structure
CAS No.
93129-94-3
Chemical Name:
(1R,3S)-5-[2-[(1R,3aR,7aS)-1-[(2R,5S)-5-hydroxy-6-methyl-heptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol
Synonyms
CB91456900;Tacalcitol monohydrate;24(R)-Dihydroxyvitamin D3;1,24-dihydroxy Vitamin D3 (hydrate);24(R)-Dihydroxyvitamin D3 monohydrate;1,24(R)-DihydroxyvitaMin D3, Monohydrate;1-alpha,24(R)-Dihydroxyvitamin D3 monohydrate;9,10-Secocholesta-5,7,10(19)-triene-1,3,24-triol,Monohydrate, (1a,3b,5Z,7E,24R)- (9CI);(1R,3S)-5-[2-[(1R,3aR,7aS)-1-[(2R,5S)-5-hydroxy-6-Methyl-heptan-2-yl]-7a-Methyl-2,3,3a,5,6,7-hexahyd;Curatoderm monohydrate|||TV 02 monohydrate|||TV-02H monohydrate|||1,24(R)-Dihydroxyvitamin D3 monohydrate
CBNumber:
CB91456900
Molecular Formula:
C27H46O4
Molecular Weight:
434.66
MDL Number:
MFCD13184757
MOL File:
93129-94-3.mol
MSDS File:
SDS
Last updated:2023-06-08 09:02:10
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(1R,3S)-5-[2-[(1R,3aR,7aS)-1-[(2R,5S)-5-hydroxy-6-methyl-heptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol Properties

storage temp. Store at -20°C
solubility DMSO
form Powder
Stability Light Sensitive
FDA UNII B3Q63NVN9R

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS08,GHS07,GHS06
Signal word  Danger
Hazard statements  H310-H317-H330-H300-H372-H334-H319
Precautionary statements  P262-P264-P270-P280-P302+P350-P310-P322-P361-P363-P405-P501-P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P264-P270-P301+P310-P321-P330-P405-P501-P260-P264-P270-P314-P501-P261-P285-P304+P341-P342+P311-P501-P260-P271-P284-P304+P340-P310-P320-P403+P233-P405-P501-P264-P280-P305+P351+P338-P337+P313P
NFPA 704
0
4 0

(1R,3S)-5-[2-[(1R,3aR,7aS)-1-[(2R,5S)-5-hydroxy-6-methyl-heptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 12079 1,24-dihydroxy Vitamin D3 (hydrate) ≥98% 93129-94-3 500μg $97 2024-03-01 Buy
Cayman Chemical 12079 1,24-dihydroxy Vitamin D3 (hydrate) ≥98% 93129-94-3 1mg $145 2024-03-01 Buy
Cayman Chemical 12079 1,24-dihydroxy Vitamin D3 (hydrate) ≥98% 93129-94-3 5mg $337 2024-03-01 Buy
TRC T004050 TacalcitolMonohydrate 93129-94-3 25mg $1125 2021-12-16 Buy
Medical Isotopes, Inc. 33768 TacalcitolMonohydrate 93129-94-3 5mg $1225 2021-12-16 Buy
Product number Packaging Price Buy
12079 500μg $97 Buy
12079 1mg $145 Buy
12079 5mg $337 Buy
T004050 25mg $1125 Buy
33768 5mg $1225 Buy

(1R,3S)-5-[2-[(1R,3aR,7aS)-1-[(2R,5S)-5-hydroxy-6-methyl-heptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol Chemical Properties,Uses,Production

Description

Vitamin D aids in the absorption of calcium and has central roles in bone formation and maintenance, hypertension, cancer, and immunity. In addition, the active form of vitamin D, 1,25-dihydroxy vitamin D3, decreases the proliferation and increases differentiation of keratinocytes. 1,24-dihydroxy Vitamin D3 is an analog of 1,25-dihydroxy vitamin D3 which, when used in a 4 μg/g ointment, safely and effectively suppresses psoriasis. It also is effective at increasing the time interval between phototherapy cycles when ultraviolet light is used for psoriasis. 1,24-dihydroxy Vitamin D3 inhibits the growth of both normal and psoriatic human keratinocytes (IC50 ~ 10 nM) via the vitamin D receptor. It also suppresses the production of RANTES and IL-8 by human dermal fibroblasts and reduces cutaneous lymphocyte-associated antigen on CD4+ T cells, impairing migration and skin infiltration.

Uses

Tacalcitol Monohydrate is used as a vitamin D analog used in combination with Imatinib (G407000) in the therapy of non-small cell lung cancer. It is a COVID19-related research product.

(1R,3S)-5-[2-[(1R,3aR,7aS)-1-[(2R,5S)-5-hydroxy-6-methyl-heptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol Preparation Products And Raw materials

Raw materials

Preparation Products

(1R,3S)-5-[2-[(1R,3aR,7aS)-1-[(2R,5S)-5-hydroxy-6-methyl-heptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol Suppliers

Global( 59)Suppliers
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Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 16216 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30253 58
Shanxi Xuanran Import and Export Trade Co., Ltd. 		+8617735180244 mike_yan@xuanranglobal.com CHINA 4022 58
AFINE CHEMICALS LIMITED 		+86-0571-85134551 info@afinechem.com China 15395 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20314 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 57511 58
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J & K SCIENTIFIC LTD. 010-82848833 400-666-7788 jkinfo@jkchemical.com China 96815 76
Supplier Advantage
Shanghai Daken Advanced Materials Co.,Ltd 		58
BOC Sciences 		58
TargetMol Chemicals Inc. 		58
Career Henan Chemica Co 		58
Shanxi Xuanran Import and Export Trade Co., Ltd. 		58
AFINE CHEMICALS LIMITED 		58
Henan Fengda Chemical Co., Ltd 		58
Aladdin Scientific 		58
Chemwill Asia Co.,Ltd. 58
J & K SCIENTIFIC LTD. 76

93129-94-3((1R,3S)-5-[2-[(1R,3aR,7aS)-1-[(2R,5S)-5-hydroxy-6-methyl-heptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol)Related Search:

Phytol Tacalcitol
(1R,3S)-5-[2-[(1R,3aR,7aS)-1-[(2R,5S)-5-hydroxy-6-methyl-heptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol 1,24(R)-DihydroxyvitaMin D3, Monohydrate (1R,3S)-5-[2-[(1R,3aR,7aS)-1-[(2R,5S)-5-hydroxy-6-Methyl-heptan-2-yl]-7a-Methyl-2,3,3a,5,6,7-hexahyd 9,10-Secocholesta-5,7,10(19)-triene-1,3,24-triol,Monohydrate, (1a,3b,5Z,7E,24R)- (9CI) 1-alpha,24(R)-Dihydroxyvitamin D3 monohydrate Tacalcitol monohydrate 1,3-Cyclohexanediol, 4-methylene-5-[(2E)-2-[(1R,3aS,7aR)-octahydro-1-[(1R,4R)-4-hydroxy-1,5-dimethylhexyl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-, hydrate , (1R,3S,5Z)- 24(R)-Dihydroxyvitamin D3 1,24-dihydroxy Vitamin D3 (hydrate) 24(R)-Dihydroxyvitamin D3 monohydrate 1,3-Cyclohexanediol, 4-methylene-5-[(2E)-2-[(1R,3aS,7aR)-octahydro-1-[(1R,4R)-4-hydroxy-1,5-dimethylhexyl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-, hydrate (1:1), (1R,3S,5Z)- CB91456900 Curatoderm monohydrate|||TV 02 monohydrate|||TV-02H monohydrate|||1,24(R)-Dihydroxyvitamin D3 monohydrate 93129-94-3