XJTU-L453
- CAS No.
- 3008290-92-1
- Chemical Name:
- XJTU-L453
- Synonyms
- XJTU-L453
- CBNumber:
- CB914907796
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
XJTU-L453 Chemical Properties,Uses,Production
Uses
XJTU-L453 is a PI3Kα inhibitor with an IC50 value of 0.4 nM. XJTU-L453 can inhibit the proliferation of breast cancer cell lines T47D and MCF7, with IC50 values of 0.2 μM and 0.5 μM, respectively. XJTU-L453 can inhibit the PI3K pathway, induce cell cycle arrest, and trigger cell apoptosis (apoptosis). XJTU-L453 also has antitumor activity in MCF7 xenograft mice[1].
IC 50
PI3Kα
References
[1] Shi X, et al. Rational Design of a Novel 6H-Benzo[c]chromen Series as Selective PI3Kα Inhibitors. J Med Chem. 2024 Aug 19. DOI:10.1021/acs.jmedchem.4c00992
XJTU-L453 Preparation Products And Raw materials
Raw materials
Preparation Products
XJTU-L453 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. | 17702719238 17702719238 | sales@sun-shinechem.com | China | 1006 | 64 |
| Nantong Hi-Future Biotechnology Co., Ltd | 18051384581 | sales@chemhifuture.com | China | 3019 | 58 |
| Supplier | Advantage |
|---|---|
| WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. | 64 |
| Nantong Hi-Future Biotechnology Co., Ltd | 58 |