H-ALA-TYR-PRO-GLY-LYS-PHE-NH2
- CAS No.
- 352017-71-1
- Chemical Name:
- H-ALA-TYR-PRO-GLY-LYS-PHE-NH2
- Synonyms
- AY-NH;AY-NH2;PAR4-AP;AYPGKF-NH2;AYPGKFAMIDE;PAR-4 aMide, Mouse;PAR-4 AGONIST AMIDE;Allantoin Impurity 3;ALA-TYR-PRO-GLY-LYS-PHE-NH2;PAR-4 Agonist Peptide, amide
- CBNumber:
- CB9174223
- Molecular Formula:
- C34H48N8O7
- Molecular Weight:
- 680.79
- MDL Number:
- MFCD06796234
- MOL File:
- 352017-71-1.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
Safety Statements | 22-24/25 |
---|---|
WGK Germany | 3 |
H-ALA-TYR-PRO-GLY-LYS-PHE-NH2 price More Price(19)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Alfa Aesar | J66921 | Selective Protease-Activated Receptor 4 (PAR4) Agonist | 352017-71-1 | 1mg | $65.9 | 2023-06-20 | Buy |
Alfa Aesar | J66921 | Selective Protease-Activated Receptor 4 (PAR4) Agonist | 352017-71-1 | 5mg | $212 | 2021-12-16 | Buy |
Tocris | 1487 | AY-NH2 | 352017-71-1 | 1 | $309 | 2021-12-16 | Buy |
TRC | A795103 | AY-NH2 | 352017-71-1 | 1mg | $280 | 2021-12-16 | Buy |
Usbiological | 254695 | AY-NH2 | 352017-71-1 | 1mg | $573 | 2021-12-16 | Buy |
H-ALA-TYR-PRO-GLY-LYS-PHE-NH2 Chemical Properties,Uses,Production
Uses
AY-NH2 is used in the synthetic preparation of PAR4 agonist peptides towards PAR4 receptor activation.
Biological Activity
ay-nh2 is a selective agonist of par4 with ec50 value of 11 μm [1].protease-activated receptor-4 (par4) is a member of pars and plays an important role in mediating cellular effects of thrombin through acting g-proteins i, 12/13 (rho and ras activation) and q (calcium signaling) [2].ay-nh2 is a potent par4 agonist and has a higher (~10 fold) activity than gypgkf-nh2. using rat platelet aggregation assay, it was shown that ay-nh2 had highly platelet aggregation ability than gy-nh2 and gf-nh2 [1]. when tested with platelet-rich plasma harvested from wild-type c57bl6 mice, ay-nh2 treatment exhibited highly agonist activity on par4 while had no effect on other pars [3].in male wistar rats model of paw oedema, i.pl. injection of ay-nh2 markedly reduced the nociceptive score in response to both noxious and non-noxious mechanical stimuli, thus inhibiting carrageenan-induced mechanical hyperalgesia and allodynia [4].
storage
Store at -20°C
References
[1]. hollenberg, m.d., et al., proteinase-activated receptor-4: evaluation of tethered ligand-derived peptides as probes for receptor function and as inflammatory agonists in vivo. br j pharmacol, 2004. 143(4): p. 443-54.
[2]. yu, g., et al., increased expression of protease-activated receptor 4 and trefoil factor 2 in human colorectal cancer. plos one, 2015. 10(4): p. e0122678.
[3]. faruqi, t.r., et al., structure-function analysis of protease-activated receptor 4 tethered ligand peptides. determinants of specificity and utility in assays of receptor function. j biol chem, 2000. 275(26): p. 19728-34.
[4]. asfaha, s., et al., protease-activated receptor-4: a novel mechanism of inflammatory pain modulation. br j pharmacol, 2007. 150(2): p. 176-85.
H-ALA-TYR-PRO-GLY-LYS-PHE-NH2 Preparation Products And Raw materials
Raw materials
Preparation Products
H-ALA-TYR-PRO-GLY-LYS-PHE-NH2 Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
Shanghai Longyu Biotechnology Co., Ltd. | +8619521488211 | info@longyupharma.com | China | 2534 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29821 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
Hangzhou Go Top Peptide Biotech | 0571-88211921 | sales1@gotopbio.com | CHINA | 2609 | 58 |
Alfa Chemistry | Info@alfa-chemistry.com | United States | 24072 | 58 | |
Chengdu Youngshe Chemical Co., Ltd. | +8618108235634 | Cecilia@youngshechem.com | China | 2345 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
Hebei Miaoyin Technology Co.,Ltd | +86-17367732028 +86-17367732028 | kathy@hbyinsheng.com | China | 3581 | 58 |
Nanjing TGpeptide | +86-13347807150 +86-13347807150 | support@tgpeptide.com | China | 3279 | 58 |
View Lastest Price from H-ALA-TYR-PRO-GLY-LYS-PHE-NH2 manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2020-02-17 | H-ALA-TYR-PRO-GLY-LYS-PHE-NH2
352017-71-1
|
US $7.00 / KG | 1KG | 99% | 100KG | Career Henan Chemical Co | ||
2020-02-17 | H-ALA-TYR-PRO-GLY-LYS-PHE-NH2
352017-71-1
|
US $7.00 / KG | 1KG | 99% | 100KG | Career Henan Chemical Co |
- H-ALA-TYR-PRO-GLY-LYS-PHE-NH2
352017-71-1
- US $7.00 / KG
- 99%
- Career Henan Chemical Co
- H-ALA-TYR-PRO-GLY-LYS-PHE-NH2
352017-71-1
- US $7.00 / KG
- 99%
- Career Henan Chemical Co