1-Aminobenzotriazole
- CAS No.
- 1614-12-6
- Chemical Name:
- 1-Aminobenzotriazole
- Synonyms
- ABT;1H-benzo[d][1,2,3]triazol-1-aMine;SKL134;9406-00-9;RARECHEM AQ NN 0550;TIMTEC-BB SBB004208;1-BENZOTRIAZOLAMINE;1-AMINOBENZOTRIAZOLE;3-Aminobenzotriazole;benzotriazol-1-amine
- CBNumber:
- CB9185384
- Molecular Formula:
- C6H6N4
- Molecular Weight:
- 134.14
- MDL Number:
- MFCD00132902
- MOL File:
- 1614-12-6.mol
- MSDS File:
- SDS
| Melting point | 81-84 °C (lit.) |
|---|---|
| Boiling point | 237.24°C (rough estimate) |
| Density | 1.2769 (rough estimate) |
| refractive index | 1.7000 (estimate) |
| RTECS | DM1235000 |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Soluble in DMSO (up to 30mg/ml) |
| form | Crystalline Powder |
| pka | 2.09±0.30(Predicted) |
| color | Yellow to beige or light brown |
| Water Solubility | slightly soluble |
| BRN | 607843 |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| CAS DataBase Reference | 1614-12-6(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 9EFF75BJ1O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29349990 | |||||||||
| NFPA 704 |
|
1-Aminobenzotriazole price More Price(60)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A3940 | 1-Aminobenzotriazole | 1614-12-6 | 50mg | $79.5 | 2024-03-01 | Buy |
| Sigma-Aldrich | A3940 | 1-Aminobenzotriazole | 1614-12-6 | 250mg | $276 | 2024-03-01 | Buy |
| TCI Chemical | A1464 | 1-Aminobenzotriazole >98.0%(GC) | 1614-12-6 | 1g | $250 | 2024-03-01 | Buy |
| TCI Chemical | A1464 | 1-Aminobenzotriazole >98.0%(GC) | 1614-12-6 | 5g | $855 | 2024-03-01 | Buy |
| Alfa Aesar | J63610 | 1-Aminobenzotriazole, 98% | 1614-12-6 | 1g | $479 | 2024-03-01 | Buy |
1-Aminobenzotriazole Chemical Properties,Uses,Production
Description
1-Aminobenztriazole (1614-12-6) is a pan-specific cytochrome P450 inhibitor acting as a suicide substrate.1,2?Blocks omega-oxidation of arachidonic acid but not its epoxidation.3
Chemical Properties
yellow to beige or light brown crystalline powder
Uses
1-Aminobenzotriazole has been used as a cytochrome P450 inhibitor to study the effects of estrogen on H2O2-induced premature senescence of vascular smooth muscle cells from old rats It has also been used to study the estrogen receptor-mediated effects of 17β-estradiol.
Uses
1-Aminobenzotriazole is used as a Suicide inhibitor of cytochrome P450 and chloroperoxidase, an inhibitor of oxidative drug metabolism in biochemical pharmacology and toxicology studies.
Biochem/physiol Actions
1-Aminobenzotriazole (1-ABT) is used as an in vitro tool in drug discovery. It can differentiate the P450 from non-P450 enzyme systems. 1-ABT exhibits inhibitory action by covalent alteration of the heme prosthetic group in the P450 enzyme.
References
1) Mugford?et al.?(1995),?1-Aminobenzotriazole-Induced Destruction of Hepatic and Renal Cytochrome P450 in Male Sprague-Dawley Rats; Fundam. Appl. Tox.,?19?43 2) Emoto?et al.?(2005),?In Vitro Inhibitory Effect of 1-Aminobenzotriazole on Drug Oxidations in Human Liver Microsomes: A Comparison With SKF-525A; Drug Metab. Pharmacokinet.,?20?351 3) Su?et al.?(1998),?Inhibition of Renal Arachidonic Acid Omega-Hydroxylase Activity With ABT Reduces Blood Pressure in the SHR; Am. J. Physiol.,?275?R426
1-Aminobenzotriazole Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29884 | 58 |
| Hebei Jimi Trading Co., Ltd. | +86 319 5273535 | bestoneforyou@sina.com | CHINA | 287 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 17322 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34553 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
View Lastest Price from 1-Aminobenzotriazole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | 1-Aminobenzotriazole
1614-12-6
|
US $41.00-57.00 / mg | 98.77% | 10g | TargetMol Chemicals Inc. | ||
 |
2021-07-02 | 1-Aminobenzotriazole
1614-12-6
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2019-07-06 | 1-Aminobenzotriazole
1614-12-6
|
US $8.00 / kg | 1kg | 99% | 10TON | Career Henan Chemical Co |
-
- 1-Aminobenzotriazole
1614-12-6
- US $41.00-57.00 / mg
- 98.77%
- TargetMol Chemicals Inc.
-
- 1-Aminobenzotriazole
1614-12-6
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 1-Aminobenzotriazole
1614-12-6
- US $8.00 / kg
- 99%
- Career Henan Chemical Co