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QUISQUALIC ACID

QUISQUALIC ACID structure

CAS No.: 52809-07-1

Chemical Name:: QUISQUALIC ACID

Synonyms: QUISQUALATE;QUISQUALIC ACID;L-QUISQUALIC ACID;(+)-QuisqualicAci;Quisqualinic acid;()-QUISQUALIC ACID;(+)-QUISQUALIC ACID;L(+)-QUISQUALIC ACID;Quisqualic acid (7CI);QUISQUALIC ACID USP/EP/BP

CBNumber:: CB9198500

Molecular Formula:: C5H7N3O5

Molecular Weight:: 189.13

MDL Number:: MFCD00069337

MOL File:: 52809-07-1.mol

MSDS File:: SDS

Last updated:2023-06-30 15:45:59

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QUISQUALIC ACID Properties

Melting point	185-187°C dec.
alpha	D20 +17.0° (c = 2.0 in 6M HCl)
Boiling point	324.36°C (rough estimate)
Density	1.6649 (rough estimate)
refractive index	1.6190 (estimate)
storage temp.	2-8°C
solubility	NH₄OH 1 M: 20 mg/mL, clear, colorless
pka	2.12±0.10(Predicted)
form	powder
color	white to off-white
Water Solubility	Soluble in ethanol, water. Insoluble in organic solvents.
Merck	13,8177
BRN	1078734
Stability	Stable. Incompatible with strong oxidizing agents.
FDA UNII	8OC22C1B99

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H312-H332

Precautionary statements

P261-P280h-P301+P312a-P304+P340-P321-P501a

Hazard Codes

Risk Statements

20/21/22

Safety Statements

26-36

WGK Germany

NFPA 704

	0
3		0

QUISQUALIC ACID price More Price(20)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	Q2128	Quisqualic acid powder	52809-07-1	1mg	$63	2024-03-01	Buy
Sigma-Aldrich	Q2128	Quisqualic acid powder	52809-07-1	5mg	$357	2024-03-01	Buy
Alfa Aesar	J61591	(+)-Quisqualic acid, 99+%	52809-07-1	5mg	$228.65	2024-03-01	Buy
Alfa Aesar	J61591	(+)-Quisqualic acid, 99+%	52809-07-1	10mg	$414.65	2024-03-01	Buy
Cayman Chemical	20211	L-Quisqualic Acid ≥99%	52809-07-1	1mg	$56	2024-03-01	Buy

Product number	Packaging	Price	Buy
Q2128	1mg	$63	Buy
Q2128	5mg	$357	Buy
J61591	5mg	$228.65	Buy
J61591	10mg	$414.65	Buy
20211	1mg	$56	Buy

QUISQUALIC ACID Chemical Properties,Uses,Production

Description

L-Quisqualic acid is a natural analog of glutamate that acts as an agonist at AMPA-selective and metabotropic glutamate receptors (EC₅₀s = 170, 10, 40, and 29 nM at GluR-A, mGluR1, mGluR3, and mGluR5, respectively), as well as the ionotropic kainate receptor (GRIK4; K_i = 6.43 nM). L-Quisqualic acid is used to study receptor dynamics and as an excitotoxin to selectively destroy neurons in the brain or spinal cord.

Chemical Properties

Off-White Solid

Uses

Quisqualic acid has been used to test ligand-gated receptors in spiral ganglion neurons.

Uses

Quisqualic acid is used to differentiate between mGluR-1 and mGluR-4. L-Quisqualic acid is an activator of GluR.

Uses

An amino acid that is able to function as an agonist at multiple excitatory amino acid receptor substrates in the central nervous system. It also has high affinity for the kainate, AMPA and the metabotropic receptors. Inhibits the Ca2+/Cl-dependent glutamic acid uptake system in brain synaptic plasma membrane preparations.

Definition

ChEBI: Quisqualic acid is a non-proteinogenic alpha-amino acid.

General Description

Quisqualate/ Quisqualic acid is obtained from the fruits and seeds of Quisqualis chinensis. It is an agonist at two subsets of excitatory amino acid receptors metabotropic receptors that indirectly mediate calcium mobilization from intracellular stores and, ionotropic receptors that directly control membrane channels. L-quisqualic acid is an agonist of the neurotransmitter L-glutamate.

Biological Activity

Glutamate receptor agonist acting at AMPA receptors and metabotropic glutamate receptors positively linked to phosphoinositide hydrolysis. Sensitizes neurons in hippocampus to depolarization by L-AP6 (the so called 'quis' effect). Also available as part of the Group I mGlu Receptor Tocriset™ .

Biochem/physiol Actions

Active enantiomer of quisqualic acid; excitatory amino acid at glutamate receptors.

storage

Store at RT

Purification Methods

It has been purified by ion-exchange chromatography on Dowex 50W (x 8, H+ form); the desired fractions are lyophilised and recrystallised from H2O/EtOH. It has IR (KBr) : 3400-2750br, 1830s, 1775s, 1745s and 1605s cm-1;maxand 1H NMR (NaOD/D2O, pH 13) : 3.55-3.57 (1H m, X of ABX, H-2), 3.72-3.85 (2H, AB of ABX, H-3), 1 3C NMR (D2O) : 50.1t, 53.4d, 154.8s, 159.7s and 171.3s. [Baldwin et al. J Chem Soc, Chem Commun 256 1985.] It is a quasiqualate receptor agonist [Joels et al. Proc Natl Acad Sci USA 86 3404 1989].

QUISQUALIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

QUISQUALIC ACID Suppliers

Global( 137)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29811	58
Shanghai UCHEM Inc.	+862156762820 +86-13564624040	sales@myuchem.com	China	7629	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	22785	58
Nextpeptide Inc	+86-0571-81612335 +8613336028439	sales@nextpeptide.com	China	19908	58
Labnetwork lnc.	+86-27-50766799 +8618062016861	contact@labnetwork.com	China	19987	58
Henan Aochuang Chemical Co.,Ltd.	+86-0371-63689365 +8618638391208	sales@aochuangchem.com	China	9245	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8467	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43340	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+undefined18621343501	product@acmec-e.com	China	33338	58

Supplier	Advantage
Hubei Jusheng Technology Co.,Ltd.	58
career henan chemical co	58
Shanghai UCHEM Inc.	58
Dideu Industries Group Limited	58
Nextpeptide Inc	58
Labnetwork lnc.	58
Henan Aochuang Chemical Co.,Ltd.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
LEAPCHEM CO., LTD.	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58

View Lastest Price from QUISQUALIC ACID manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2022-09-23	Quisqualic Acid 52809-07-1	US $0.00-0.00 / kg	1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
	2020-01-10	QUISQUALIC ACID 52809-07-1	US $2.00 / KG	1g	98%MIN	ASK	Career Henan Chemical Co

Quisqualic Acid
52809-07-1
US $0.00-0.00 / kg
98%
Henan Aochuang Chemical Co.,Ltd.

QUISQUALIC ACID
52809-07-1
US $2.00 / KG
98%MIN
Career Henan Chemical Co

52809-07-1(QUISQUALIC ACID)Related Search:

4-Phosphonophenylglycine AIDA L-AP4 IBOTENIC ACID (+-)-2-AMINO-3-PHOSPHONOPROPIONIC ACID ( AP-3)NMDA ANTAGONIST

MPPG Albizziin 2,3-Diaminopropionic acid Hydroxyurea 3-(N-Methylamino)-L-alanine

QUISQUALIC ACID L-2,3-Diaminopropionic acid 3-UREIDOPROPIONIC ACID 1,2,4-OXADIAZOLIDINE-3,5-DIONE ALPHA-BENZYLQUISQUALIC ACID

[3H]QUISQUALIC ACID 2-(2-AMINO-ETHYL)-[1,2,4]OXADIAZOLIDINE-3,5-DIONE 1-Hydroxy-3-methylurea

1of4

3-(3,5-DIOXO-1,2,4-OXADIAZOLIDIN-2-YL)-L-ALANINE L(+)-QUISQUALIC ACID L-QUISQUALIC ACID L-(+)-A-AMINO-3,5-DIOXO-1,2,4-OXADIAZOLIDINE-2-PROPANOIC ACID (L)-(+)-ALPHA-AMINO-3,5-DIOXO-1,2,4-OXADIAZOLIDINE-2-PROPANOIC ACID BETA-[3,5-DIOXO-1,2,4-OXADIAZOLIDIN-2-YL]-L-ALANINE BETA-(3,5-DIOXO-1,2,4-OXADIZOLIDIN-2-YL)-L-ALANINE (+)-QUISQUALIC ACID QUISQUALIC ACID L-(+)-a-Amino-3,5-Dioxo-1,2,4-oxadiazolidine-2-pro β-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)-l-alanine QUISQUALATE L-(+)-α-Amino-3,5-dioxo-1,2,4-oxadiazolidine-2-propanoic Acid β-(3,5-Dioxo-1,2,4-oxadiazolidin-2-yl)-L-alanine, 3-(3,5-Dioxo-1,2,4-oxadiazolidin-2-yl)-L-alanine (S)-2-Amino-3-(3,5-dioxotetrahydro-1,2,4-oxadiazole-2-yl)propionic acid (αS)-α-Amino-3,5-dioxo-1,2,4-oxadiazolidine-2-propanoic acid (αS)-α-Amino-3,5-dioxotetrahydro-1,2,4-oxadiazole-2-propionic acid Quisqualic acid,β-(3,5-Dioxo-1,2,4-oxadiazolidin-2-yl)-L-alanine, 3-(3,5-Dioxo-1,2,4-oxadiazolidin-2-yl)-L-alanine (S)-2-aMino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)propanoic acid 1,2,4-Oxadiazolidine-2-propanoicacid, a-aMino-3,5-dioxo-, (aS)- ()-QUISQUALIC ACID 1,2,4-Oxadiazolidine-2-propanoic acid, α-amino-3,5-dioxo-, (αS)- (+)-QuisqualicAci QUISQUALIC ACID USP/EP/BP Quisqualinic acid Quisqualic acid (7CI) 52809-07-1 C5H7N3O5 Amino Acids and Peptides Biochemicals and Reagents BioChemical Cell Signaling and Neuroscience Cell Biology Modified Amino Acids Ligand-Gated Ion Channels I - Z Ionotropic Glutamate Receptor Modulators Ion Channels Heterocycles Glutamate Amino Acids 13C, 2H, 15N Amino Acids & Derivatives Neurochemicals Glutamate receptor