1,2-Dimethoxyethane

1,2-Dimethoxyethane Properties

Melting point	-69 °C
Boiling point	85 °C(lit.)
Density	0.867 g/mL at 25 °C(lit.)
vapor density	3.1 (20 °C, vs air)
vapor pressure	48 mm Hg ( 20 °C)
refractive index	n20/D 1.379(lit.)
Flash point	32 °F
storage temp.	Store below +30°C.
solubility	1000g/l soluble
form	Liquid
color	Clear
Odor	water-wh. liq., sharp ethereal odor
explosive limit	10.4%
Water Solubility	Miscible
Sensitive	Air Sensitive
λmax	λ: 220 nm Amax: 1.00 λ: 250 nm Amax: 0.20 λ: 300 nm Amax: 0.03 λ: 350-400 nm Amax: 0.01
Merck	14,3224
BRN	1209237
Dielectric constant	7.2（25℃）
Stability	Stable, but explosive peroxides may form on exposure to air. Test for the presence of peroxides before heating. Avoid heat, light, air. Highly flammable. Store under inert gas.
InChIKey	XTHFKEDIFFGKHM-UHFFFAOYSA-N
LogP	-0.21 at 25℃
CAS DataBase Reference	110-71-4(CAS DataBase Reference)
EWG's Food Scores	2
FDA UNII	GXS24JF5IW
NIST Chemistry Reference	Ethane, 1,2-dimethoxy-(110-71-4)
EPA Substance Registry System	Ethylene glycol dimethyl ether (110-71-4)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02,GHS07,GHS08

Signal word

Danger

Hazard statements

H225-H315-H332-H360FD

Precautionary statements

P202-P210-P233-P303+P361+P353-P304+P340+P312-P308+P313

Hazard Codes

F,T

Risk Statements

60-61-11-19-20-38

Safety Statements

53-45

RIDADR

UN 2252 3/PG 2

WGK Germany

1

RTECS

KI1451000

F

3-10-23

Autoignition Temperature

396 °F

TSCA

Yes

HazardClass

3

PackingGroup

II

HS Code

29091900

NFPA 704

	3
1		0

1,2-Dimethoxyethane price More Price(49)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	E27408	1,2-Dimethoxyethane ReagentPlus?, ≥99%, inhibitor-free	110-71-4	18L	$1670	2024-03-01	Buy
Sigma-Aldrich	8.00856	Ethylene glycol dimethyl ether (stabilised) for synthesis	110-71-4	1L	$168	2024-03-01	Buy
Sigma-Aldrich	8.00856	Ethylene glycol dimethyl ether (stabilised) for synthesis	110-71-4	10L	$708	2024-03-01	Buy
Sigma-Aldrich	72405	1,2-Dimethoxyethane analytical standard	110-71-4	5ml	$171	2024-03-01	Buy
Sigma-Aldrich	259527	1,2-Dimethoxyethane anhydrous, 99.5%, inhibitor-free	110-71-4	6x1l	$996	2024-03-01	Buy

Product number	Packaging	Price	Buy
E27408	18L	$1670	Buy
8.00856	1L	$168	Buy
8.00856	10L	$708	Buy
72405	5ml	$171	Buy
259527	6x1l	$996	Buy

1,2-Dimethoxyethane Chemical Properties,Uses,Production

Description

1,2-Dimethoxyethane (DME) is a liquid ether used as an aprotic solvent. It is also known as glyme, monoglyme, dimethyl glycol, ethylene glycol, dimethyl ether, dimethyl cellosolve, and DME. It has the special ability to form chelates thanks to the high flexibility of its chains. Moreover, DME is the molecular model system for the poly(oxyethylene) chain. It is commonly used as a solvent in batteries and in organometallic reaction chemistry since it has higher boiling than diethyl ether and THF[1].

Chemical Properties

Ethylene glycol dimethyl ether, also called 1,2-Dimethoxyethane, is a colorless liquid with a strong smell similar to ether. It is stable and does not easily react. It can dissolve different resins and cellulose, and can be mixed with water and various organic solvents like alcohols, ketones, and esters in any amount. Its solubility can be changed by diluting it with water or specific solvents.

Uses

1,2-Dimethoxyethane is widely used as a solvent for electrolyte of lithium batteries, polysilicones, oligo- and polysaccharides. It plays an important role in Grignard reactions, Suzuki reactions and Stille couplings in organometallic chemistry and in pharmaceutical synthesis. It is a higher boiling point solvent and is used as an alternative to diethyl ether and tetrahydrofuran. It is used for the etching of synthetic polymers like polytetrafluoroethylene and other fluoropolymers with alkali metal dispersions.

Definition

ChEBI: 1,2-dimethoxyethane is a diether that is the 1,2-dimethyl ether of ethane-1,2-diol. It has a role as a non-polar solvent. It is functionally related to an ethylene glycol.

Application

Monoglyme serves as an electrolyte solution component for lithium batteries. It is also frequently utilized as a solvent in organometallic reactions, particularly those involving organolithium compounds. Additionally, it can act as a ligand in certain chemical reactions.

General Description

A liquid with a sharp odor. Less dense than water. Flash point 34°F. Mildly toxic by ingestion and inhalation. Severely irritates skin and eyes. Vapors heavier than air. Used to make other chemicals.

Air & Water Reactions

Highly flammable. Slightly soluble in water.

Reactivity Profile

When the solvent, 1,2-Dimethoxyethane, was poured into a funnel previously used to introduce the lithium aluminum hydride, a fire ignited the funnel, [MCA Case History 1182(1966)].

Hazard

Moderate fire risk.

Health Hazard

If ingested causes nausea, vomiting, cramps, weakness, coma.

Fire Hazard

Behavior in Fire: Containers may explode in fires.

Safety Profile

An experimental teratogen. Other experimental reproductive effects. Readdy forms an explosive peroxide. A very dangerous fire hazard when exposed to heat, flame, or oxidzers. Mixture with lithium tetrahydroaluminate may ignite orexplode if heated. When heated to decomposition it emits acrid smoke and fumes. See also GLYCOL ETHERS.

Synthesis

1,2-Dimethoxyethane is derived from the reaction of ethylene glycol monomethyl ether with sodium metal and methyl chloride. The ethylene glycol monomethyl ether and the metal sodium were refluxed together until the metal sodium was completely reacted, the temperature was lowered to 45° C., and methyl chloride was introduced. After the reaction is completed, fractional distillation is performed to collect fractions at 84-85.5°C to obtain 1,2-Dimethoxyethane.

Purification Methods

Traces of water and acidic materials have been removed from it by refluxing with Na, K or CaH2, decanting and distilling from Na, K, CaH2 or LiAlH4. The reaction has been speeded up by using vigorous high-speed stirring with molten potassium. For virtually complete elimination of water, 1,2-dimethoxyethane has been dried with Na-K alloy until a characteristic blue colour is formed in the solvent at Dry-ice/cellosolve temperatures: the solvent is kept with the alloy until distilled for use [Ward J Am Chem Soc 83 1296 1961]. Alternatively, glyme, refluxed with benzophenone and Na-K, is dry enough if, on distillation, it gives a blue colour of the ketyl immediately on addition to benzophenone and sodium [Ayscough & Wilson J Chem Soc 5412 1963]. It has also been purified by distillation under N2 from sodium benzophenone ketyl (see above). [Beilstein 1 IV 2376.]

References

[1] Weixing Li . “The microwave spectroscopy study of 1,2-dimethoxyethane.” Journal of Molecular Spectroscopy 337 (2017): Pages 3-8.

1,2-Dimethoxyethane Preparation Products And Raw materials

Raw materials

2-Methoxyethanol Sodium hydroxide

Preparation Products

Tetrahydrocurcumin 2-Aminoquinoline 3-AMINOBIPHENYL 5-CHLORO-2'-DEOXYURIDINE TERT-BUTYL 4-(4-FORMYL-1,3-THIAZOL-2-YL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE

2-Bromo-5-hydroxypyridine radical ion(1+) 4-BENZYL-MORPHOLINE-2-CARBOXYLIC ACID 1-METHYL-1H-INDOLE-5-BORONIC ACID 2,2-DIMETHYL PROPANE DIOL-1,3-CYCLIC ESTER EUROPIUM D-3-TRIFLUOROACETYLCAMPHORATE 2-Chloro-5-cyano-3-methylpyridine

Quinacridone 4-CHLORO-1,3-DIMETHYLPYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLIC ACID 3-N-Boc-amino-azetidine 4-CHLORO-7-METHYLTHIENO[3,2-D]PYRIMIDINE 3-TRIFLUOROACETYL-D-CAMPHOR

TEMAFLOXACIN Azetidine N,N-DIPHENYLQUINACRIDONE Pigment Red 122 4-Thiazolecarboxylic acid

2-CHLORO-5-IODO-3-METHYLPYRIDINE 7-Methylthieno[3,2-d]pyrimidin-4(3H)-one ETHYL 4-METHOXY-3-OXO-BUTANOATE Sarafloxacin 10-UNDECYNOIC ACID

3,4-DICHLORO-N-METHYLANILINE N,N'-Dimethylquinacridone THIOPHENE-2,5-DICARBOXYLIC ACID MONOMETHYL ESTER 4-(Dicyanomethylene)-2-tert-butyl-6-(1,1,7,7-tetramethyljulolidin-4-yl-vinyl)-4H-pyran TERT-BUTYL 4-(5-FORMYL-4-METHYL-1,3-THIAZOL-2-YL)PIPERIDINE-1-CARBOXYLATE

TERT-BUTYL 5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)ISOINDOLINE-2-CARBOXYLATE Beraprost 1,1,1-TRICHLOROACETONE 2,3,5,6-Tetrafluorobenzyl alcohol 2-PHENYLMALONAMIDE

5-FORMYL-2-THIOPHENECARBOXYLIC ACID 4'-BROMO-3'-FLUOROACETANILIDE 2,3,5,6-Tetrafluoro-4-methylbenzyl alcohol

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1,2-Dimethoxyethane Suppliers

Global( 535)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Anhui lixing chemical co.,ltd	+86-5638152626 +86-17756305689	gdq@lixingchem.com	China	10	58
SHANGHAI KEAN TECHNOLOGY CO., LTD.	+8613817748580	cooperation@kean-chem.com	China	40066	58
Hebei Mojin Biotechnology Co., Ltd	+86 13288715578 +8613288715578	sales@hbmojin.com	China	12837	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29791	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21639	55
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418679 +8618949832763	info@tnjchem.com	China	2986	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29886	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	+86 18953170293	sales@sdzschem.com	China	2930	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10310	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58

Supplier	Advantage
Anhui lixing chemical co.,ltd	58
SHANGHAI KEAN TECHNOLOGY CO., LTD.	58
Hebei Mojin Biotechnology Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
Hefei TNJ Chemical Industry Co.,Ltd.	55
career henan chemical co	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	58
Shenzhen Nexconn Pharmatechs Ltd	58
Hubei Jusheng Technology Co.,Ltd.	58

View Lastest Price from 1,2-Dimethoxyethane manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-02	1,2-Dimethoxyethane 110-71-4	US $0.00 / KG	180KG	98%min	300KG/month	WUHAN FORTUNA CHEMICAL CO., LTD
2024-03-27	1,2 DIMETHOXYETAHNE 110-71-4	US $0.00-0.00 / KG	180KG	99.5%MIN	4000tons	Anhui lixing chemical co.,ltd
2024-03-27	1,2 DIMETHOXYETHANE 110-71-4	US $0.00-0.00 / KG	180KG	99.5%MIN	4000tons	Anhui lixing chemical co.,ltd

1,2-Dimethoxyethane
110-71-4
US $0.00 / KG
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

1,2 DIMETHOXYETAHNE
110-71-4
US $0.00-0.00 / KG
99.5%MIN
Anhui lixing chemical co.,ltd

1,2 DIMETHOXYETHANE
110-71-4
US $0.00-0.00 / KG
99.5%MIN
Anhui lixing chemical co.,ltd

1,2-Dimethoxyethane Spectrum

DME(110-71-4)MS DME(110-71-4)¹HNMR DME(110-71-4)¹³CNMR DME(110-71-4)IR1 DME(110-71-4)Raman

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ETHYLENE GLYCOL DIMETHYL ETHER ACS (1,2-DIMETHOXYETHANE) Ethylene glycol dimethyl ether, stabilized with BHT, extra pure, 99+% Ethylene glycol dimethyi ether MONOETHYLENGLYCOL DIMETHYL ETHER Ethylene Glycol Dimethyl ether (DME) ETHYLENE GLYCOL DIMETHYL ETHER ( MONOGLYME ) 1,2-DIMETHYOXYETHANE, GC STANDARD 1,2-DIMETHYOXYETHANE, 99.5% 1.2-DIMETHOXYETHANE AR +99% ETHYLENE GLYCOL DIMETHYL ETHER, ANHYDROU S, 99.5% 1,2-Dimethoxyethane, 99+%, stab. with 0.01% BHT 1,2-dimethoxyethane ethylene glycol dimethyl ether EGDME Dimethoxyethane, 1,2- 1,2-DIMETHOXYETHANE extrapure 1,2-Dimethoxyethane, Reagent Grade, 99+% Dimethylglycol, Ethylene glycol dimethyl ether, mono-Glyme, Monoglyme Ethylene glycol dimethyl ether, 99+%, stabilized with bht, extra pure Ethylene glycol dimethyl ether, stabilized with BHT, extra pure 1,2-DiMethoxyethane, 99+%, stab. with BHT 1,2-DiMethoxyethane, Anhydrous, SeptuM-Sealed Bottle, DriSolv(R) 1,2-DiMethoxyethane, Reagent 1,2-DiMethoxyethane, SuperDry, J&KSeal 1,2-DiMethoxyethane, 99.5%, SpcDry, with Molecular sieves, Water≤50 ppM (by K.F.), SpcSeal 1,2-Dimethoxyethane in dimethyl sulfoxide 1,2-DiMethoxyethane, 99%, SpcDry, Water≤50 ppM (by K.F.), SpcSeal 1,2-DimethoxyethaneDry 1,2-Dimethoxyethaney 1,2-Dimethoxyethane anhydrous, 99.5%, inhibitor-free 1,2-Dimethoxyethane for HPLC, 99.9%, inhibitor-free 1,2-Dimethoxyethane ReagentPlus(R), >=99%, inhibitor-free 1,2-Dimethoxyethane, 99%, stabilized glycoldimethylether monoethyleneglycoldimethylether 1,2-DIMETHYOXYETHANE DIMETHYLGLYCOL DIMETHYL CELLOSOLVE 1,2-Dimethoxyethane, Internal Standard in RFA gasoline Ethylene glycol dimethyl ether(Glyme) 1,2-Dimethoxyethane ,99.5% Ethylene glycol dimethyl ether, AcroSeal, Extra Dry, 99% 1,2-Dimethoxyethane,Dimethylglycol, Ethylene glycol dimethyl ether, Monoglyme, mono-Glyme 1.2-Dimethoxyethane 1g [110-71-4] Dimethyl Cellosolve Dimethyl Glycol DME Ethylene Glycol Dimethyl Ether Ethyleneglycol diMethyl ether ,99.5% Ethylene glycol diMethyl ether, 99%, Extra Dry, AcroSeal Ethylene glycol diMethyl ether, AcroSeal, Extra Dry, 99% 100ML Ethylene glycol diMethyl ether, stabilized with BHT, extra pure, 99+% 1LT Ethylene glycol diMethyl ether, stabilized with BHT, extra pure, 99+% 2.5LT 1,2-DiMethoxyethane(ethylene glycol diMethyl ether) ETHYLENE GLYCOL DIMETHYL ETHER (STABILIS 1,2-DiMethoxyethane, absolute, over Molecular sieve 1,2-DiMethoxyethane, anhydrous Ethylene Glycol Dimethyl Ether 〔1,2-Dimethyoxyethane〕 Ethylene glycol dimethyl ether,99+%,extra pure,stabilized with BHT Ethylene glycol dimethyl ether,99%,Extra Dry 1,2-DIMETHOXYETHANE, ANHYDROUS, 99.5%, I Residual Solvent Class 2 - 1,2-Dimethoxyethane Ethylene glycol dimethyl ether (stabilised) for synthesis