ChemicalBook >> CAS DataBase List >>Isatoic Anhydride
Isatoic Anhydride
- CAS No.
- 118-48-9
- Chemical Name:
- Isatoic Anhydride
- Synonyms
- 1H-BENZO[D][1,3]OXAZINE-2,4-DIONE;Isatoic;2-(carboxyamino)-benzoicacicyclicanhydride;BENZOXAZINEDIONE;4H-3,1-Benzoxazine-2,4(1H)-dione;1,2-Dihydro-3,1-benzoxazine-2,4-dione;4H-3;Isatoic Ac;4(1H)-dione;1-Benzoxazine-2
- CBNumber:
- CB9238051
- Molecular Formula:
- C8H5NO3
- Molecular Weight:
- 163.13
- MDL Number:
- MFCD00006700
- MOL File:
- 118-48-9.mol
- MSDS File:
- SDS
Last updated:2025-01-27 09:38:02
| Melting point | 233 °C (dec.) (lit.) |
|---|---|
| Boiling point | 290.19°C (rough estimate) |
| Density | 1,52 g/cm3 |
| bulk density | 600kg/m3 |
| vapor density | 5.6 (vs air) |
| refractive index | 1.5510 (estimate) |
| Flash point | 308 °C |
| storage temp. | Store below +30°C. |
| solubility | 0.3g/l |
| pka | 11.06±0.20(Predicted) |
| form | Powder |
| color | Beige to brown |
| Water Solubility | decomposes |
| Sensitive | Moisture Sensitive |
| BRN | 136786 |
| LogP | 0.978 (est) |
| CAS DataBase Reference | 118-48-9(CAS DataBase Reference) |
| EWG's Food Scores | 1-2 |
| FDA UNII | R8TFA74Y4U |
| NIST Chemistry Reference | Isatoic anhydride(118-48-9) |
| EPA Substance Registry System | 2H-3,1-Benzoxazine-2,4(1H)-dione (118-48-9) |
| UNSPSC Code | 12352115 |
| NACRES | NA.23 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H317-H319 | |||||||||
| Precautionary statements | P261-P264-P272-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36-43 | |||||||||
| Safety Statements | 24-26-37 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | DM3100000 | |||||||||
| F | 3 | |||||||||
| Autoignition Temperature | >600 °C | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29349990 | |||||||||
| Hazardous Substances Data | 118-48-9(Hazardous Substances Data) | |||||||||
| Toxicity | LD50 orally in Rabbit: > 6400 mg/kg LD50 dermal Rabbit > 2000 mg/kg | |||||||||
| NFPA 704 |
|
Isatoic Anhydride price More Price(46)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | I12808 | Isatoic anhydride 96% | 118-48-9 | 100g | $42.8 | 2024-03-01 | Buy |
| Sigma-Aldrich | I12808 | Isatoic anhydride 96% | 118-48-9 | 500g | $149 | 2024-03-01 | Buy |
| Sigma-Aldrich | 8.04784 | Isatoic anhydride for synthesis | 118-48-9 | 100g | $73.2 | 2024-03-01 | Buy |
| Sigma-Aldrich | 8.04784 | Isatoic anhydride for synthesis | 118-48-9 | 500g | $461 | 2023-01-07 | Buy |
| TCI Chemical | I0081 | Isatoic Anhydride >98.0%(HPLC)(T) | 118-48-9 | 25g | $60 | 2024-03-01 | Buy |
Isatoic Anhydride Chemical Properties,Uses,Production
Synthesis
Isatoic Anhydride is synthesized from indole (9a) by stirring in a 4:1 mixture of DMF/H2O for 16 h at room temperature.
1 H NMR (DMSO-d6): δ11.73 (s, br., 1H), 7.92 (d, J = 7.8 Hz, 1H), 7.74 (t, J = 7.8 Hz, 1H), 7.26 (t, J = 7.8 Hz, 1H), 7.16 (d, J = 7.8 Hz, 1H).
Chemical Properties
BEIGE TO BROWN POWDER
Uses
Isatoic anhydride is a potent inactivator of α-chymotrypsin and inactivates stoichiometrically. Isatoic Anhydride is an important compound in the preparation of serine protease inhibitors.
Preparation
Phosphorus tribromide (0.035 mol) was added to a solution of N-carbethoxy- or N-carbobenzoxy-anthranilic acid (0.1 mol;prepared by coupling anthranilic acid with the corresponding carbalkoxy chloride in the usual way) in anhydrous diethyl ether (100 mL). After 24 h at room temperature, isatoic anhydride had separated as a microcrystalline product. It was collected by filtration, washed with dry diethyl ether, and recrystallized from ethanol. Yield ca. 90%.
Definition
A bicyclic molecule composed of a benzene ring attached at the oand mpositions to a heterocyclic ring. It forms useful anthranilic acid derivatives by reaction with hydrogen.
Flammability and Explosibility
Non flammable
Purification Methods
Recrystallise it from EtOH or 95% EtOH (30mL/g) or dioxane (10mL/g) and dry it in a vacuum. [Wagner & Fegley Org Synth Coll Vol III 488 1955, Ben-Ishai & Katchalski J Am Chem Soc 74 3688 1952, UV: Zentmyer & Wagner J Org Chem 14 967 1949, Beilstein 27 II 299, 27III/IV 3330.]
Isatoic Anhydride Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
Global( 464)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Weibang Biotechnology Co., Ltd | +8615531157085 | abby@weibangbio.com | China | 8804 | 58 |
| Hebei Mujin Biotechnology Co.,Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12829 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531153977 | allison@yan-xi.com | China | 5855 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5887 | 58 |
| Hebei Weibang Biotechnology Co., Ltd | +8617732866630 | bess@weibangbio.com | China | 18147 | 58 |
| Hebei Kingfiner Technology Development Co.Ltd | +86-15532196582 +86-15373005021 | lisa@kingfinertech.com | China | 3007 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 3692 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29792 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21632 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32965 | 60 |
View Lastest Price from Isatoic Anhydride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-02-18 | Isatoic Anhydride
118-48-9
|
US $10.00 / kg | 1kg | 99% | 20ton | Hebei Zhuanglai Chemical Trading Co.,Ltd | |
 |
2025-02-17 | Isatoic anhydride
118-48-9
|
US $2.00 / KG | 1KG | ≥99% | 500mt/year | Jinan Finer Chemical Co., Ltd | |
 |
2025-02-14 | Isatoic Anhydride
118-48-9
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mujin Biotechnology Co.,Ltd |
-
- Isatoic Anhydride
118-48-9
- US $10.00 / kg
- 99%
- Hebei Zhuanglai Chemical Trading Co.,Ltd
-
- Isatoic anhydride
118-48-9
- US $2.00 / KG
- ≥99%
- Jinan Finer Chemical Co., Ltd
-
- Isatoic Anhydride
118-48-9
- US $0.00 / KG
- 99%
- Hebei Mujin Biotechnology Co.,Ltd
118-48-9(Isatoic Anhydride)Related Search:
6-METHYL ISATINIC ANHYDRIDE
N-methylisatoic anhydride
4-NITRO-ISATOIC ANHYDRIDE
Isatoic Anhydride
5-Bromoisatoic anhydride
6-CHLOROISATIN
3-[2-(Diethylamino)ethyl]-2H-1,3-benzoxazine-2,4(3H)-dione
5-Fluoroisatonic anhydride
6-Fluoroisatoic anhydride
4-Chloro-isatoic anhydride
1of4
2,4-Dioxo-1,2-dihydro-4H-3,1-benzoxazine
4H-3,1-Benzoxazin-2,4-(1H)-dion
4H-3,1-Benzoxazin-2,4(1H)-dion
Anthranilic acid, N-carboxy-, cyclic anhydride
Benzoic acid, 2-(carboxyamino)-, cyclic anhydride
Benzoicacid,2-(carboxyamino)-,cyclicanhydride
Isato acid anhydride
1,2-dihydro-4h-3,1-benzoxazine-2,4-dione
1,4-DIHYDRO-2H-3,1-BENZOXAZIN-2,4-DIONE
3,1-BENZOXAZINE-2,4(1H)-DIONE
2H-3,1-BENZOXAZINE-2,4(1H)-DIONE
LABOTEST-BB LT00053651
ISATOLC ANHYDRIDE
ISATOIC ANHYDRIDE
ANTHRANILIC ACID N-CARBOXYLIC ACID ANHYDRIDE
TIMTEC-BB SBB003928
N-CARBOXYANTHRANILIC ACID CYCLIC ANHYDRIDE
2H-3,1-benzoxazine-2,4(1H)-dio
N-carboxyanthranilic acid anhydride
1,4-Dihydro-2H-3,1-benzoxazine-2,4-dione
Isatoic anhydride,98%
Isatoic anhydride, 98% 100GR
3,1-Benzoxazine-2,4(1H)-dione, Anthranilic acid N-carboxylic acid anhydride
1H-3,1-Benzoxazine-2,4-dione
Isatoic acid anhydride
isatoicacidanhydride
Isatonicanhydride
Isatosαureanhydrid
n-carboxy-anthranilicacicyclicanhydride
N-Carboxyanthranilicanbydride
n-carboxyanthranilicanhydride
1H-Benz[d][1,3]oxazine-2,4-dione
2-(CarboxyaMino)benzoic Acid Cyclic Anhydride
Isatoic Ac
ISATOIC ANHYDRIDE FOR SYNTHESIS
Isatoic anhydrate
1H-3,1-benzoxazine-2,4-quinone
1-Benzoxazine-2
4(1H)-dione
4H-3
IsatoicAnhydride>
Isatin anhydride
Isatoic anhydride, 97%,
1,2-Dihydro-3,1-benzoxazine-2,4-dione
2-(carboxyamino)-benzoicacicyclicanhydride
4H-3,1-Benzoxazine-2,4(1H)-dione
1H-BENZO[D][1,3]OXAZINE-2,4-DIONE
BENZOXAZINEDIONE
Isatoic
Isatoic anhydride (6CI)
Isatioc anhydride
satoic Anhydride
118-48-9
C6H4C2HNO3
CC6H4NHCOO
C8H5NO3
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