2-Oxo-(2H)-furo(2,3-h)-1-benzopyran
- CAS No.
- 523-50-2
- Chemical Name:
- 2-Oxo-(2H)-furo(2,3-h)-1-benzopyran
- Synonyms
- angecin;ANGELICIN;ANGELICINE;NSC 404563;isopsoralin;ISOPSORALEN;ISOPSORALENE;ISOBERGAPTEN;ANGELICIN(P);Angelicin>
- CBNumber:
- CB9249112
- Molecular Formula:
- C11H6O3
- Molecular Weight:
- 186.16
- MDL Number:
- MFCD00064930
- MOL File:
- 523-50-2.mol
- MSDS File:
- SDS
| Melting point | 132-134°C |
|---|---|
| Boiling point | 104°C/4mmHg(lit.) |
| Density | 1.2477 (rough estimate) |
| refractive index | 1.6310 (estimate) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) |
| form | Solid |
| color | White |
| λmax | 302nm(EtOH)(lit.) |
| BRN | 153970 |
| LogP | 2.080 |
| CAS DataBase Reference | 523-50-2(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | CZZ080D7BD |
| NIST Chemistry Reference | 2H-furo[2,3-h]-1-benzopyran-2-one(523-50-2) |
| IARC | 3 (Vol. 40, Sup 7) 1987 |
| UNSPSC Code | 85151701 |
| NACRES | NA.25 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P301+P312+P330-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 20/21/22-36/37/38-40 | |||||||||
| Safety Statements | 26-36/37/39-37/39-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | LV0940000 | |||||||||
| HS Code | 29322090 | |||||||||
| Hazardous Substances Data | 523-50-2(Hazardous Substances Data) | |||||||||
| NFPA 704 |
|
2-Oxo-(2H)-furo(2,3-h)-1-benzopyran price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A0956 | Angelicin | 523-50-2 | 10mg | $159.6 | 2024-03-01 | Buy |
| Sigma-Aldrich | A0956 | Angelicin | 523-50-2 | 25mg | $349.8 | 2024-03-01 | Buy |
| TCI Chemical | A2573 | Angelicin >98.0%(GC) | 523-50-2 | 25mg | $411 | 2024-03-01 | Buy |
| Cayman Chemical | 11683 | Angelicin ≥98% | 523-50-2 | 5mg | $98 | 2024-03-01 | Buy |
| Cayman Chemical | 11683 | Angelicin ≥98% | 523-50-2 | 10mg | $157 | 2024-03-01 | Buy |
2-Oxo-(2H)-furo(2,3-h)-1-benzopyran Chemical Properties,Uses,Production
Synthesis
Iodination of commercially available umbelliferone (7-hydroxycoumarin) yields 7-hydroxy-8-iodocoumarin. Acetoxy group can be introduced into hydroxyl of 7-hydroxy-8-iodocoumarin, which is used to create vaginol or vaginidiol with an isopropyl Grignard reagent and commercially available epoxy aldehydes. Subsequent acid-catalysed fragmentation of vaginol with dichloromethane in trifluoroacetic acid yields angelicin.
Toxicity
The LD50 of angelicin is 322 mg/kg which shows acute toxicity if orally administered to rats. The possible consequences are alteration in circadian rhythm and righting reflex, ataxia and analgesia.
Description
Angelicin is a furanocoumarin typically isolated from the seeds of P. corylifolia. Like other furanocoumarins, angelicin has antibacterial activities against a number of Gram (+) and Gram (-) bacteria. It has also been shown to prevent tacrine-
Chemical Properties
White Solid
Uses
Antifungal
Definition
ChEBI: Angelicin is a furanocoumarin.
Synthesis Reference(s)
Tetrahedron, 51, p. 3087, 1995 DOI: 10.1016/0040-4020(95)00070-O
Clinical Use
Angelicin derivatives are used to treat psoriasis and cancer. One way of treating these diseases is by photochemotherapy (PUVA) which combines UV irradiation with photosensitizing chemical. Also, it was shown that it is actively inhibits the synthesis of nucleic acids in tumor cells thereby decreasing their growth.
2-Oxo-(2H)-furo(2,3-h)-1-benzopyran Preparation Products And Raw materials
Raw materials
1of4
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29871 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +8618080483897 | sales@biopurify.com | China | 3772 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | sales@dolonchem.com | CHINA | 2972 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| NanJing Spring & Autumn Biological Engineering CO., LTD. | +8613815430202 | sale02@cqherb.com | CHINA | 376 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49476 | 58 |
View Lastest Price from 2-Oxo-(2H)-furo(2,3-h)-1-benzopyran manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | Angelicin
523-50-2
|
US $35.00 / mg | 99.98% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-04-02 | Angelicin
523-50-2
|
US $1050.00 / g | 1g | 98 | 500 Kg | R&D Scientific Inc. | |
 |
2023-02-24 | Isopsoralen
523-50-2
|
US $0.00 / mg | 5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. |
-
- Angelicin
523-50-2
- US $35.00 / mg
- 99.98%
- TargetMol Chemicals Inc.
-
- Angelicin
523-50-2
- US $1050.00 / g
- 98
- R&D Scientific Inc.
-
- Isopsoralen
523-50-2
- US $0.00 / mg
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.