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Dabigatran Etexilate Mesylate

Dabigatran Etexilate Mesylate structure

CAS No.: 872728-81-9

Chemical Name:: Dabigatran Etexilate Mesylate

Synonyms: Pradaxa;Pradaxa Mesylate;Dabigatran mesylate;Dabigatran Etexilate Mesylate API;Ethyl 3-(2-(((4-(N-((hexyloxy)carbonyl)carbamimidoyl)phenyl)amino)methyl)-1-methyl-N-(pyridin-;Hexyl 2-(4-(((5-((3-ethoxy-3-oxopropyl)(pyridin-2-yl)carbaMoyl)-1-Methyl-1H-benzo[d]iMidazol-2-yl)Methyl)aMino)benzylidene)hydrazinecarboxylate Methanesulfonate;(E)-hexyl 2-(4-((5-((3-ethoxy-3-oxopropyl)(pyridin-2-yl)carbaMoyl)-1-Methyl-1H-benzo[d]iMidazol-2-yl)MethylaMino)benzylidene)hydrazinecarboxylate Methanesulfonate;ethyl 3-(2-(((4-(N-((hexyloxy)carbonyl)carbamimidoyl)phenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate methanesulfonate;N-[[2-[[[4-[[[(Hexyloxy)carbonyl]amino]iminomethyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-beta-alanine ethyl ester monomethanesulfonat;Dabig

CBNumber:: CB92500679

Molecular Formula:: C35H45N7O8S

Molecular Weight:: 723.85

MDL Number:: MFCD17215180

MOL File:: 872728-81-9.mol

MSDS File:: SDS

Last updated:2025-01-27 09:38:02

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Dabigatran Etexilate Mesylate Properties

Melting point	>125°C
storage temp.	Refrigerator
solubility	DMSO (Slightly, Heated), Methanol (Slightly)
form	Solid
color	White to Pale Yellow
InChIKey	XETBXHPXHHOLOE-UHFFFAOYSA-N
SMILES	S(O)(=O)(=O)C.CN1C(=NC2C=C(C(=O)N(C3N=CC=CC=3)CCC(=O)OCC)C=CC1=2)CNC1C=CC(C(=N)NC(=O)OCCCCCC)=CC=1
FDA UNII	SC7NUW5IIT
NCI Drug Dictionary	dabigatran etexilate mesylate
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS08

Signal word

Danger

Hazard statements

H413

NFPA 704

	0
2		0

Dabigatran Etexilate Mesylate price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	007470	Dabigatran Etexilate Mesylate	872728-81-9	10mg	$425	2021-12-16	Buy
ApexBio Technology	A3345	Dabigatranetexilatemesylate	872728-81-9	100mg	$523	2021-12-16	Buy
Biosynth Carbosynth	FD20773	Dabigatran etexilate mesylate	872728-81-9	2g	$340	2021-12-16	Buy
ApexBio Technology	A3345	Dabigatranetexilatemesylate	872728-81-9	50mg	$361	2021-12-16	Buy
Biosynth Carbosynth	FD20773	Dabigatran etexilate mesylate	872728-81-9	100mg	$65	2021-12-16	Buy

Product number	Packaging	Price	Buy
007470	10mg	$425	Buy
A3345	100mg	$523	Buy
FD20773	2g	$340	Buy
A3345	50mg	$361	Buy
FD20773	100mg	$65	Buy

Dabigatran Etexilate Mesylate Chemical Properties,Uses,Production

Description

Dabigatran etexilate mesylate is a clinical direct thrombin inhibitor and a new type of oral anticoagulant. It can inhibit the formation of thrombus by reversibly and potently competing with the fibrin-specific binding site of thrombin to block fibrin generation.

Chemical Properties

Off-White to Pale Yellow Solid

Uses

Nonpeptide, direct thrombin inhibitor. Antithrombotic.

Clinical Use

Dabigatran Etexilate Mesylate is a direct thrombin inhibitor indicated to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation.

Definition

ChEBI: A methanesulfonate salt obtained by reaction of dabigatran etexilate with one equivalent of dabigatran etexilate. A prodrug for dabigatran, a thrombin inhibitor and anticoagulant which is used for the prevention of stroke and systemic embolism.

brand name

Pradaxa

Biological Activity

Dabigatran etexilate mesylate (BIBR 1048MS) is an orally active prodrug of Dabigatran. Dabigatran etexilate mesylate has anticoagulant properties and can prevent venous thromboembolism and stroke due to atrial fibrillation.

Mechanism of action

Dabigatran etexilate mesylate is a prodrug of dabigatran that is metabolized in the body and converted to the active dabigatran. Compared with warfarin, dabigatran etexilate mesylate does not require frequent monitoring of coagulation function and dose adjustment during treatment, and there are fewer interactions between drugs and is not affected by eating, thus improving patients' medication compliance.

Side effects

The most common adverse reactions to Dabigatran Etexilate Mesylate (150 mg) were bleeding and gastrointestinal events (i.e. dyspepsia, nausea, epigastric pain, gastrointestinal bleeding, and diarrhoea). Very few patients experienced drug hypersensitivity (including urticaria, rash and pruritus), anaphylactic oedema, anaphylactic reactions and anaphylaxis.

in vivo

Dabigatran etexilate mesylate (BIBR 1048MS; oral; 10, 20 and 50 mg/kg for rats and 1, 2.5 and 5 mg/kg for monkeys) has dose- and time-dependent anticoagulant effects and has maximum effects between 30 and 120 min after administration, respectively.Dabigatran etexilate mesylate maximally and significantly prolongs partial thromboplastin time (aPTT) to 25.2, 38.4 and 78.3 s in 30 min after 10, 20 and 50 mg/kg oral doses, respectively.Dabigatran etexilate mesylate maximally prolongs the aPTT to 34.3 s, 44.0 s, and 63.0 s, respectively, 2h after 1, 2.5 or 5 mg/kg doses in the monkey.

Dabigatran Etexilate Mesylate synthesis

Synthesis of Dabigatran Etexilate Mesylate from Dabigatran etexilate and Methanesulfonic acid

Dabigatran Etexilate Mesylate Preparation Products And Raw materials

Raw materials

Dabigatran etexilate Methanesulfonic acid

Preparation Products

Dabigatran Etexilate Mesylate Suppliers

Global( 479)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Protheragen-ING	+16313385890	info@protheragen-ing.com	United States	3868	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615531157085	abby@chuanghaibio.com	China	8808	58
Hebei Mujin Biotechnology Co.,Ltd	+86 13288715578 +8613288715578	sales@hbmojin.com	China	12809	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5868	58
shandong perfect biotechnology co.ltd	+86-53169958659 +86-13153181156	sales@sdperfect.com	China	294	58
Anhui Ruihan Technology Co., Ltd	+8617756083858	daisy@anhuiruihan.com	China	973	58
Hebei Weimiao Import and Export Trade Co., Ltd.	+86-19948166995 +86-19948166995	sale01@hbweimiao.com	China	76	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20234	58
hebei hongtan Biotechnology Co., Ltd	+852-6619 3215 +86-17731935328	sales03@chemcn.cn	China	970	58
Hebei Saisier Technology Co., LTD	+86-18400010335 +86-18034520335	admin@hbsaisier.cn	China	1015	58

Supplier	Advantage
Protheragen-ING	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Hebei Mujin Biotechnology Co.,Ltd	58
Hebei Chuanghai Biotechnology Co,.LTD	58
shandong perfect biotechnology co.ltd	58
Anhui Ruihan Technology Co., Ltd	58
Hebei Weimiao Import and Export Trade Co., Ltd.	58
Henan Fengda Chemical Co., Ltd	58
hebei hongtan Biotechnology Co., Ltd	58
Hebei Saisier Technology Co., LTD	58

What is the Pharmacokinetics of Dabigatran etexilate mesylate?
Dabigatran etexilate mesylate, also known by its brand name, Pradaxa, is a type of anticoagulant blood thinner that treats and....
Nov 20，2024

View Lastest Price from Dabigatran Etexilate Mesylate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-04-27	Dabigatran Etexilate Mesylate 872728-81-9	US $0.00 / Kg/Bag	100g	98.5%min	10KGS	WUHAN FORTUNA CHEMICAL CO., LTD
2025-04-23	Dabigatran Etexilate Mesylate 872728-81-9	US $10.00 / KG	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-03-28	Dabigatran Etexilate Mesylate 872728-81-9	US $6.00 / KG	1KG	99%	20TONS	Hebei Longbang Technology Co., Ltd

Dabigatran Etexilate Mesylate
872728-81-9
US $0.00 / Kg/Bag
98.5%min
WUHAN FORTUNA CHEMICAL CO., LTD

Dabigatran Etexilate Mesylate
872728-81-9
US $10.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

Dabigatran Etexilate Mesylate
872728-81-9
US $6.00 / KG
99%
Hebei Longbang Technology Co., Ltd

Dabigatran Etexilate Mesylate Spectrum

Dabigatran Etexilate Mesylate(872728-81-9)¹HNMR

872728-81-9(Dabigatran Etexilate Mesylate)Related Search:

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N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-(2-pyridinyl)-beta-alanine ethyl ester hydrochloride Dabigatran Etexilate iMpurity D Dabigatran iMpurity E Des-(N-2-pyridyl-β-alanine Ethyl Ester) Dabigatran Etexilate 5-Ethyl Carboxylate (Dabigatran IMpurity) Dabigatran iMpurity F

Dabigatran etexilate Dabigatran

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Dabigatran etexilate mesylate (Z)-ethyl 3-(2-(((4-(N'-((hexyloxy)carbonyl)carbamimidoyl)phenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate methanesulfonate Dabigatran etexilate mesylate,Pradaxa Dabigatran etexilate Mesylate 872728-81-9 [[[(Hexyloxy)carbonyl]aMino]iMinoMethyl]phenyl]aMino]Methyl]-1-Methyl-1H-benziMidazol-5-yl]carbonyl]-N-2-pyridinyl-beta-alanineethylesterMonoMethanesulfonat N-[[2-[[[4-[[[(Hexyloxy)carbonyl]aMino]iMinoMethyl]phenyl]aMino]Methyl]-1-Methyl-1H-benziMidazol-5-y BIBR 1048MS N-[[2-[[[4-[[[(Hexyloxy)carbonyl]aMino]iMinoMethyl]phenyl]aMino]Methyl]-1-Methyl-1H-benziMidazol-5-yl]carbonyl]-N-2-pyridinyl-β-alanine Ethyl Ester Methanesulfonate Dabigatran etexilate Methanesulfonate PRADAXA; BIBR 1048MS; DABIGATRAN ETEXILATE METHANESULFONATE ate MesyL atran EtexiL Dabig Dabigatran EtexiL Dabigatran Etexilate Mesylate USP/EP/BP Dabigatran Etexilate Mesylate Pellet Dabigatran Etexilate Mesylate- IH B-Alanine, N-[[2-[[[4-[[[(hexyloxy) carbonyl] amino] iminomethyl] phenyl] amino] methyl]-1-methyl-1H-benzimidazol-5-yl] carbonyl]-N-2-pyridinyl -,ethyl ester, methanesulfonate N-[[2-[[[4-[[[(Hexyloxy)carbonyl] amino]iminomethyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-β-alanine ethyl ester methanesulfonate Dabigatran Etexilate MesylateQ: What is Dabigatran Etexilate Mesylate Q: What is the CAS Number of Dabigatran Etexilate Mesylate Q: What is the storage condition of Dabigatran Etexilate Mesylate Q: What are the applications of Dabigatran Etexilate Mesylate Dabigatran Mesylate Reference N-[[2-[[[4-[[[(Hexyloxy)carbonyl]amino]iminomethyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-beta-alanine ethyl ester monomethanesulfonat supplier in Chin CS-900 3-([2-[[(4-(N-n-hexyloxycarbonylcarbamimidoyl)-phenylamino)-methyl]]-1-methyl-1H-benzimidazole-5-carbonyl]-pyridin-2-yl-amino)ethyl propionate mesylate Ethyl 3-(2-(((4-(N-((hexyloxy)carbonyl)carbamimidoyl)phenyl)amino)methyl)-1-methyl-N-(pyridin- N-[[2-[[[4-[[[(Hexyloxy)carbonyl]amino]iminomethyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-beta-alanine ethyl ester monomethanesulfonat Pradaxa Hexyl 2-(4-(((5-((3-ethoxy-3-oxopropyl)(pyridin-2-yl)carbaMoyl)-1-Methyl-1H-benzo[d]iMidazol-2-yl)Methyl)aMino)benzylidene)hydrazinecarboxylate Methanesulfonate (E)-hexyl 2-(4-((5-((3-ethoxy-3-oxopropyl)(pyridin-2-yl)carbaMoyl)-1-Methyl-1H-benzo[d]iMidazol-2-yl)MethylaMino)benzylidene)hydrazinecarboxylate Methanesulfonate Pradaxa Mesylate Dabigatran Etexilate Mesylate API ethyl 3-(2-(((4-(N-((hexyloxy)carbonyl)carbamimidoyl)phenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate methanesulfonate Dabigatran mesylate Dabigatran etexilatemesi Pradaxa, Dabigatran etexilate mesylate DabigatranEtexilate Mesylate/Pellets Dabigatran Etexilate Mesylate, 10 mM in DMSO DABIGATRAN ETEXILATE MESYLATE [DRUG SUBSTANCE (NON-STERILE)] 872728-81-9 C34H41N7O5CH4O3S C35H45N7O8S Aromatics Bases & Related Reagents Heterocycles Intermediates & Fine Chemicals Nucleotides Pharmaceuticals Dabigatran etexilate mesylate API 872728-81-9