Pifithrin-α, p-Nitro
- CAS No.
- 389850-21-9
- Chemical Name:
- Pifithrin-α, p-Nitro
- Synonyms
- p-nitro-Pifithrin-α;p-nitro-Pifithrin-α;Pifithrin-α, p-Nitro;Pifithrin-α, p-Nitro;p-nitro-Pifithrin-.alpha.;Pifithrin-alpha, p-Nitro hydrobromide,;2-(2-imino-4,5,6,7-tetrahydro-1,3-benzothiazol-3-yl)-1-(4-nitrophenyl)ethanone;2-(2-IMINO-4,5,6,7-TETRAHYDROBENZO[D]THIAZOL-3(2H)-YL)-1-(4-NITROPHENYL)ETHANONE HBR
- CBNumber:
- CB92503236
- Molecular Formula:
- C15H16BrN3O3S
- Molecular Weight:
- 398.27484
- MDL Number:
- MFCD00398180
- MOL File:
- 389850-21-9.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
Pifithrin-α, p-Nitro price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Alfa Aesar | J64277 | Pifithrin-alpha, p-Nitro hydrobromide | 389850-21-9 | 5mg | $94.65 | 2024-03-01 | Buy |
| Cayman Chemical | 16209 | p-nitro-Pifithrin-α ≥95% | 389850-21-9 | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 16209 | p-nitro-Pifithrin-α ≥95% | 389850-21-9 | 5mg | $118 | 2024-03-01 | Buy |
| Cayman Chemical | 16209 | p-nitro-Pifithrin-α ≥95% | 389850-21-9 | 10mg | $214 | 2024-03-01 | Buy |
| Cayman Chemical | 16209 | p-nitro-Pifithrin-α ≥95% | 389850-21-9 | 25mg | $479 | 2024-03-01 | Buy |
Pifithrin-α, p-Nitro Chemical Properties,Uses,Production
Uses
A cell-permeable p53 inhibitor
Biological Activity
p-nitro-pifithrin-α, a cell-permeable cyclic analog of pifithrin-α, is an inhibitor of p53 activity [1].the p53 tumor suppressor gene product can induce apoptotic cell death and plays a dominant role in apoptosis, genomic stability, and inhibition of angiogenesis. the p53 has been considered to be an oncogene and the wild-type gene product actually functions as a tumour suppressor gene. p53 mutations play an important role in the development of many common human malignancies [2].in human proximal tubular cells, p-nitro-pifithrin-α (10 μm) suppressed p53-mediated tgf-β1 expression [3].
in vitro
in p53-/- cortical neuron, p-nitro-pifithrin-α exihibited a p53 inhibitory activity in preventing p53-induced death[1]. p-nitro-pifithrin-α did not prevent cortical neuronal death induced by p40met, showing the remarkable specificity in the inhibitory action of p-nitro-pifithrin-α on p53. p-nitro-pifithrin-α (300 nm) prevented p53-triggered increase in protein levels of p21/waf1, indicating that p-nitro-pifithrin-α behaved as p53 posttranscriptional activity inhibitors. p-nitro-pifithrin-α at a dose of 30 nm was sufficient to prevent the increase of p21/waf1 levels [1]. p-nitro-pifithrin-α was slowly converted into a more potent cyclized form, p-nitro cyclic pifithrin-α, when incubated in biological media (t1/2= 8 h)
in vivo
in a mouse model of non-alcoholic fatty liver disease, p-nitro-pifithrin-α attenuated steatosis and liver injury in mice fed a high-fat diet [4].
References
[1] pietrancosta n, moumen a, dono r, et al. imino-tetrahydro-benzothiazole derivatives as p53 inhibitors: discovery of a highly potent in vivo inhibitor and its action mechanism[j]. journal of medicinal chemistry, 2006, 49(12): 3645-3652.
[2] nigro j m, baker s j, preisinger a c, et al. mutations in the p53 gene occur in diverse human tumour types[j]. nature, 1989, 342(6250): 705-708.
[3] shimizu h, yisireyili m, nishijima f, et al. indoxyl sulfate enhances p53-tgf-β1-smad3 pathway in proximal tubular cells[j]. american journal of nephrology, 2013, 37(2): 97-103.
[4] derdak z, villegas k a, harb r, et al. inhibition of p53 attenuates steatosis and liver injury in a mouse model of non-alcoholic fatty liver disease[j]. journal of hepatology, 2013, 58(4): 785-791.
Pifithrin-α, p-Nitro Preparation Products And Raw materials
Raw materials
Preparation Products
Pifithrin-α, p-Nitro Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42057 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Alfa Chemistry | 1-516-6625404 | support@alfa-chemistry.com | United States | 9171 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9707 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 23963 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | 18143011203 | ET-market@chemextension.com | China | 41844 | 58 |
| ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |