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MIRA-1

CAS No.
72835-26-8
Chemical Name:
MIRA-1
Synonyms
MIRA-1;NSC 19630;p53 Activator VIII;WRN Helicase Inhibitor;1-[(1-Oxopropoxy)methyl]-1H-pyrrole-2;(2,5-dioxopyrrol-1-yl)methyl propanoate;5-dihydro-1H-pyrrol-1-yl)methyl propionate;Ethyl 2,5-Dioxo-2,5-dihydropyrrole-1-acetate;1-[(1-Oxopropoxy)methyl]-1H-pyrrole-2,5-dione;1H-Pyrrole-2,5-dione, 1-[(1-oxopropoxy)methyl]-
CBNumber:
CB92514665
Molecular Formula:
C8H9NO4
Molecular Weight:
183.16
MDL Number:
MFCD12828765
MOL File:
72835-26-8.mol
Last updated:2024-07-02 08:55:41

MIRA-1 Properties

Melting point 44 °C
Boiling point 298.2±23.0 °C(Predicted)
Density 1.307±0.06 g/cm3(Predicted)
storage temp. Store at +4°C
solubility Soluble to 100 mM in DMSO and to 100 mM in ethanol
form Powder
pka -2.79±0.20(Predicted)
color White to light yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338

MIRA-1 price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 681647 WRN Helicase Inhibitor, NSC 19630 - CAS 72835-26-8 - Calbiochem 72835-26-8 5MG $144 2024-03-01 Buy
Cayman Chemical 14858 MIRA-1 ≥98% 72835-26-8 10mg $106 2024-03-01 Buy
Cayman Chemical 14858 MIRA-1 ≥98% 72835-26-8 50mg $440 2024-03-01 Buy
Tocris 3362 MIRA-1 72835-26-8 10 $119 2021-12-16 Buy
TRC N900430 MIRA-1 72835-26-8 10mg $60 2021-12-16 Buy
Product number Packaging Price Buy
681647 5MG $144 Buy
14858 10mg $106 Buy
14858 50mg $440 Buy
3362 10 $119 Buy
N900430 10mg $60 Buy

MIRA-1 Chemical Properties,Uses,Production

Uses

The tumor suppressor gene, p53, is often mutated in most human cancers. MIRA-1 is a maleimide-derived molecule that can reactivate the mutant p53 leading to apoptosis in human tumor cells. In addition, the MIRA scaffold is an attractive lead for developing anticancer drugs that target mutant p53.

storage

Store at +4°C

5063-96-7
123-62-6
72835-26-8
Synthesis of MIRA-1 from N-MALEIMIDOMETHANOL and Propionic anhydride

MIRA-1 Preparation Products And Raw materials

Raw materials

Preparation Products

MIRA-1 Suppliers

Global( 49)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Aladdin Scientific
+1-+1(833)-552-7181 sales@aladdinsci.com United States 57511 58
Suzhou ARTK Medchem Co., Ltd.
+8618168183658 sales1@artkmedchem.com China 39009 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15848 69
VDM Biochemicals 0330-2528181 sales@vdmbio.com United States 510 64
Shanghai Raise Chemical Technology Co.,Ltd 15026594951 rs@raise-chem.com China 3374 55
Bide Pharmatech Ltd. 400-1647117 15221909166 product02@bidepharm.com China 41438 60
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8449 60
Shanghai SuperLan Chemcial Technique Centre 021-2022843681 15618226720 chaolaichem@foxmail.com China 8971 58
Henan Weituxi Chemical Technology Co., Ltd. 0371-63284658 18135795563 2885349392@qq.com China 10003 58
MIRA-1 1-[(1-Oxopropoxy)methyl]-1H-pyrrole-2,5-dione NSC 19630 1H-Pyrrole-2,5-dione, 1-[(1-oxopropoxy)methyl]- Ethyl 2,5-Dioxo-2,5-dihydropyrrole-1-acetate 1-[(1-Oxopropoxy)methyl]-1H-pyrrole-2 5-dihydro-1H-pyrrol-1-yl)methyl propionate p53 Activator VIII WRN Helicase Inhibitor inhibit,MDM-2/p53,MIRA1,Apoptosis,NSC-19630,Inhibitor,H1299,MIRA-1,SKOV,NSC19630,Anticancer,MIRA 1,Saos-2 (2,5-dioxopyrrol-1-yl)methyl propanoate 72835-26-8 Apoptosis Inducers