CYT997
- CAS No.
- 917111-44-5
- Chemical Name:
- CYT997
- Synonyms
- CS-347;CYT997;Lexibulin;Lexibulin(CYT-997);CYT997 (Lexibulin);CYT997 Lexibulin CYT-997;CYT997 ISO 9001:2015 REACH;CYT997; CYT-997; CYT 997;LEXIBULIN.;1-ethyl-3-(2-methoxy-4-(5-methyl-4-((S)-1-(pyridin-3-yl)butylamino)pyrimidin-2-yl)phenyl)urea;N-Ethyl-N'-[2-methoxy-4-[5-methyl-4-[[(1S)-1-(3-pyridinyl)butyl]amino]-2-pyrimidinyl]phenyl]ur
- CBNumber:
- CB92516533
- Molecular Formula:
- C24H30N6O2
- Molecular Weight:
- 434.53
- MDL Number:
- MFCD18206787
- MOL File:
- 917111-44-5.mol
- MSDS File:
- SDS
Boiling point | 546.9±50.0 °C(Predicted) |
---|---|
Density | 1.195 |
storage temp. | Store at -20°C |
solubility |
DMSO:69.0(Max Conc. mg/mL);158.79(Max Conc. mM) Ethanol:51.0(Max Conc. mg/mL);117.37(Max Conc. mM) |
pka | 14.01±0.70(Predicted) |
form | Powder |
color | White to off-white |
FDA UNII | 2GTU230HA1 |
NCI Drug Dictionary | lexibulin |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
NFPA 704 |
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CYT997 price More Price(21)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 18395 | CYT997 ≥98% | 917111-44-5 | 1mg | $44 | 2024-03-01 | Buy |
Cayman Chemical | 18395 | CYT997 ≥98% | 917111-44-5 | 5mg | $193 | 2024-03-01 | Buy |
Cayman Chemical | 18395 | CYT997 ≥98% | 917111-44-5 | 10mg | $341 | 2024-03-01 | Buy |
Cayman Chemical | 18395 | CYT997 ≥98% | 917111-44-5 | 50mg | $1148 | 2024-03-01 | Buy |
Biorbyt Ltd | orb154725 | lexibulin (CYT997) >98% | 917111-44-5 | 250mg | $1431.4 | 2021-12-16 | Buy |
CYT997 Chemical Properties,Uses,Production
Definition
ChEBI: 1-ethyl-3-[2-methoxy-4-[5-methyl-4-[[(1S)-1-(3-pyridinyl)butyl]amino]-2-pyrimidinyl]phenyl]urea is a member of ureas.
Biological Activity
Lexibulin (CYT997, SRI-32007) is a potent inhibitor of microtubule polymerization in cancer cell lines with IC50 of 10-100 nM. Phase 2.
in vitro
Treatment of A549 cells with CYT997 (1 μM) for 24 hours induced rapid reorganization of microtubules, including disruption of the existing microtubule network and accumulation of some cytoplasmic tubulin in plaques, resulting in significant changes in cell morphology, including Adherent cells are lost and cells are reduced. CYT997 is toxic to 16 cancer cells with IC50 ranging from 9 nM in HepG2 cells to 101 nM in KHOS/NP cells. CYT997 effectively acts on HCT15 cells, has a multi-drug resistance mechanism Pgp (MDR consistent with CYT997 destroys cellular tubulin, CYT997 effectively inhibits proliferation, induces cell cycle arrest, and induces apoptosis in human myeloid cell lines (HMCLs) and primary MM cells die.
in vivo
The half-life of CYT997 in oral-treated rats (2.5 hours) was slightly longer than that of intravenous injection (1.5 hours), and the absolute oral bioavailability was 50% to 70%. Oral administration of CYT997 to mice bearing PC3 xenografts inhibited tumor growth more effectively than Paclitaxel in a dose-dependent manner. CYT997 was also effective in an orthotopic model of mouse breast cancer 4T1 cells, some of which were resistant to Paclitaxel treatment. Intraperitoneal injection of CYT997 at a dose of 7.5 mg/kg to liver metastases significantly reduced blood flow at the 6th hour, similar to the positive control effect of CA4P at a dose of 100 mg/kg. Consistent with in vitro anti-myeloma activity, CYT997 significantly extended lifespan in a mouse model of aggressive systemic myeloid leukemia at a dose of 15 mg/kg daily.
target
Target | Value |
Microtubules (cancer cell lines) | 10 nM-100 nM |
CYT997 Preparation Products And Raw materials
CYT997 Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49392 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30250 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 8331 | 58 |
Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | gksales1@gk-bio.com | China | 9316 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33350 | 58 |
View Lastest Price from CYT997 manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-04-17 | CYT997
917111-44-5
|
US $1.10 / g | 1g | 99.0% min | 100 tons min | Shaanxi Dideu Medichem Co. Ltd | ||
2021-07-13 | Lexibulin
917111-44-5
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | ||
2021-07-09 | Lexibulin
917111-44-5
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |