4-(2-Fluorophenoxy)phenylboronic acid
- CAS No.
- 1402238-32-7
- Chemical Name:
- 4-(2-Fluorophenoxy)phenylboronic acid
- Synonyms
- IQNYGJLCROJQSI-UHFFFAOYSA-N;4-(2-Fluorophenoxy)phenylboronic acid;Boronic acid, B-[4-(2-fluorophenoxy)phenyl]-
- CBNumber:
- CB92517343
- Molecular Formula:
- C12H10BFO3
- Molecular Weight:
- 232.02
- MDL Number:
- MFCD18311840
- MOL File:
- 1402238-32-7.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2931900090 |
4-(2-Fluorophenoxy)phenylboronic acid price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC412469 | 4-(2-Fluorophenoxy)phenylboronic acid 98% | 1402238-32-7 | 100mg | $37 | 2026-06-04 | Buy |
| Apolloscientific | PC412469 | 4-(2-Fluorophenoxy)phenylboronic acid 98% | 1402238-32-7 | 250mg | $45 | 2026-06-04 | Buy |
| Apolloscientific | PC412469 | 4-(2-Fluorophenoxy)phenylboronic acid 98% | 1402238-32-7 | 1g | $134 | 2026-06-04 | Buy |
| Apolloscientific | PC412469 | 4-(2-Fluorophenoxy)phenylboronic acid 98% | 1402238-32-7 | 5g | $413 | 2026-06-04 | Buy |
| Activate Scientific | AS27412 | 4-(2-Fluorophenoxy)phenylboronic Acid 96% | 1402238-32-7 | 1g | $137 | 2026-06-04 | Buy |
4-(2-Fluorophenoxy)phenylboronic acid Chemical Properties, Uses, Production
Synthesis
5419-55-6
851199-57-0
1402238-32-7
Step 4: To a 300 mL three-necked round-bottomed flask that was pre-purged and maintained in an inert atmosphere under nitrogen protection was added a tetrahydrofuran solution (50 mL) of 1-(2-fluorophenoxy)-4-iodobenzene (3.3 g, 30.51 mmol, 1.00 equiv). The reaction system was cooled to -78 °C and n-butyllithium (n-BuLi, 4.4 mL) was slowly added dropwise under stirring. After completion of the dropwise addition, the reaction solution was continued to be stirred at -78 °C for 10 min, followed by slow dropwise addition of triisopropyl borate (2.1 g, 13.17 mmol, 1.06 equiv) at the same temperature. After completion of the dropwise addition, the reaction system was gradually warmed up to room temperature and stirred. Upon completion of the reaction, the reaction was quenched by the addition of saturated aqueous ammonium chloride (NH4Cl), followed by concentration of the reaction solution under reduced pressure. The concentrated residue was diluted with 30% aqueous potassium hydroxide (KOH) and then washed with ether. The pH of the aqueous phase was adjusted to 2-4 with 37% hydrochloric acid (HCl) and subsequently extracted with ethyl acetate. The organic layers were combined, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to give 2.2 g (90% yield) of [4-(2-fluorophenoxy)phenyl]boronic acid as a white solid.
References
[1] Patent: WO2012/158764, 2012, A1. Location in patent: Page/Page column 204-205
[2] Patent: US8673925, 2014, B1. Location in patent: Page/Page column 232
4-(2-Fluorophenoxy)phenylboronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
4-(2-Fluorophenoxy)phenylboronic acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
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