3-Amino-N-(4-methoxybenzyl)-4,6-dimethylthieno[2,3-b]pyridinecarboxamide
![3-Amino-N-(4-methoxybenzyl)-4,6-dimethylthieno[2,3-b]pyridinecarboxamide Structure](CAS/GIF/409351-28-6.gif)
- CAS No.
- 409351-28-6
- Chemical Name:
- 3-Amino-N-(4-methoxybenzyl)-4,6-dimethylthieno[2,3-b]pyridinecarboxamide
- Synonyms
- VU0152100;VU 152100;VU152100;VU 0152100;VU-0152100;3-Amino-N-(4-methoxybenzyl)-4,6-dimethylthieno[2,3-b]pyridinecarboxamide;3-Amino-N-(4-methoxybenzyl)-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide;3-Amino-N-[(4-methoxyphenyl)methyl]-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide;Thieno[2,3-b]pyridine-2-carboxamide, 3-amino-N-[(4-methoxyphenyl)methyl]-4,6-dimethyl-;VU-152100,Inhibitor,Muscarinic acetylcholine receptor,inhibit,VU0152100,VU 152100,mAChR,VU-0152100,VU 0152100
- CBNumber:
- CB92518759
- Molecular Formula:
- C18H19N3O2S
- Molecular Weight:
- 341.43
- MDL Number:
- MFCD02742972
- MOL File:
- 409351-28-6.mol
3-Amino-N-(4-methoxybenzyl)-4,6-dimethylthieno[2,3-b]pyridinecarboxamide price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | V5015 | VU0152100 ≥98% (HPLC) | 409351-28-6 | 5mg | $108 | 2024-03-01 | Buy |
| Sigma-Aldrich | V5015 | VU0152100 ≥98% (HPLC) | 409351-28-6 | 25mg | $414 | 2023-06-20 | Buy |
| Tocris | 3383 | VU152100 ≥98%(HPLC) | 409351-28-6 | 10 | $185 | 2021-12-16 | Buy |
| Tocris | 3383 | VU152100 ≥98%(HPLC) | 409351-28-6 | 50 | $778 | 2021-12-16 | Buy |
| Usbiological | 257071 | VU 152100 | 409351-28-6 | 10mg | $438 | 2021-12-16 | Buy |
3-Amino-N-(4-methoxybenzyl)-4,6-dimethylthieno[2,3-b]pyridinecarboxamide Chemical Properties,Uses,Production
Uses
VU 152100 is a positive allosteric modulator of muscarinic choline receptor M4.
Biological Activity
vu0152100 is a selective and positive allosteric modulators of m4 receptor with the ec50 value of 380±93nm[1].vu0152100 has shown a potent positive allosteric modulators that increase the response of the m4 receptor to the endogenous agonist ach in in vitro study. in addition, vu0152100 has been reported to dese-dependently potentiate the response to the agonist (ach) with the ec50 value of 1.9±0.2μm, and increase the maximal response to ach to approximately 130%. furthermore, vu0152100 has been revealed to enhance receptor activation by increasing the affinity of m4 for acetylcholine. apart from these, vu0152100 has been found to induce a 20 to 25-fold leftward shift in the potency of ach to displace [3h]nms binding to m4 receptor with the ki value from 252±19.7nm to 12.2±0.49nm [1].
storage
Store at RT
References
[1] brady ae1, jones ck, bridges tm, kennedy jp, thompson ad, heiman ju, breininger ml, gentry pr, yin h, jadhav sb, shirey jk, conn pj, lindsley cw. centrally active allosteric potentiators of the m4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats. j pharmacol exp ther. 2008 dec;327(3):941-53.
3-Amino-N-(4-methoxybenzyl)-4,6-dimethylthieno[2,3-b]pyridinecarboxamide Preparation Products And Raw materials
Raw materials
Preparation Products
3-Amino-N-(4-methoxybenzyl)-4,6-dimethylthieno[2,3-b]pyridinecarboxamide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9254 | 55 | |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9708 | 58 |
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