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COG 133

COG 133 structure

CAS No.: 514200-66-9

Chemical Name:: COG 133

Synonyms: COG 133;apoE(13;apoE(133-149);COG-133; COG133;COG 133 TFA salt;Ac- LRVRLASHLRKLRKRLL-NH2;COG 133 trifluoroacetate salt;Ac-Leu-Arg-Val-Arg-Leu-Ala-Ser-His-Leu- Arg-Lys-Leu-Arg-Lys-Arg-Leu-Leu-NH2;N-acetyl-L-leucyl-L-arginyl-L-valyl-L-arginyl-L-leucyl-L-alanyl-L-seryl-L-histidyl-L-leucyl-L-arginyl-L-lysyl-L-leucyl-L-arginyl-L-lysyl-L-arginyl-L-leucyl-L-Leucinamide;L-Leucinamide, N-acetyl-L-leucyl-L-arginyl-L-valyl-L-arginyl-L-leucyl-L-alanyl-L-seryl-L-histidyl-L-leucyl-L-arginyl-L-lysyl-L-leucyl-L-arginyl-L-lysyl-L-arginyl-L-leucyl-

CBNumber:: CB92518926

Molecular Formula:: C97H181N37O19

Molecular Weight:: 2169.71

MDL Number:: MFCD12912476

MOL File:: 514200-66-9.mol

Last updated:2023-06-30 15:45:59

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COG 133 Properties

storage temp.	-20°C
solubility	H2O: >1mg/mL
form	lyophilized
color	white
Water Solubility	Soluble to 1 mg/ml in water

SAFETY

Risk and Safety Statements

WGK Germany	3

COG 133 price More Price(9)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	C8624	COG 133 trifluoroacetate salt ≥95% (HPLC)	514200-66-9	1mg	$259	2024-03-01	Buy
Tocris	3405	COG133	514200-66-9	1	$244	2021-12-16	Buy
Usbiological	255020	COG 133	514200-66-9	1mg	$495	2021-12-16	Buy
American Custom Chemicals Corporation	PEP0004464	COG 133 95.00%	514200-66-9	5MG	$495.85	2021-12-16	Buy
ApexBio Technology	A1131	COG133	514200-66-9	10mg	$350	2021-12-16	Buy

Product number	Packaging	Price	Buy
C8624	1mg	$259	Buy
3405	1	$244	Buy
255020	1mg	$495	Buy
PEP0004464	5MG	$495.85	Buy
A1131	10mg	$350	Buy

COG 133 Chemical Properties,Uses,Production

Biological Activity

cog 133, (c97h181n37o19), a peptide with the sequence ac-leu-arg-val-arg-leu-ala-ser-his-leu-arg-lys-leu-arg-lys-arg-leu-leu-amide,mw= 2169.73.apolipoprotein e (apoe) is 299 amino acids long and transports lipoproteins(1), fat-soluble vitamins, and cholesterol into the lymph system and then into the blood. it is synthesized principally in the liver, but has also been found in other tissues such as the brain, kidneys, and spleen. in the nervous system, non-neuronal cell types, most notably astroglia and microglia, are the primary producers of apoe, while neurons preferentially express the receptors for apoe. there are seven currently identified mammalian receptors for apoe which belong to the evolutionarily conserved low density lipoprotein receptor gene family.apoe was initially recognized for its importance in lipoprotein metabolism and cardiovascular disease(2). defects in apoe result in familial dysbetalipoproteinemia aka type iii hyperlipoproteinemia (hlp iii), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron, vldl and ldl remnants[citation needed]. more recently, it has been studied for its role in several biological processes not directly related to lipoprotein transport, including alzheimer's disease (ad), immunoregulation, and cognition(3).figure1 the structures of apolipoprotein e (apoe) cog 133figure2 potential roles of apoe in neurons and alzheimer's disease

storage

Store at -20°C

References

1. Singh PP, Singh M, Mastana SS (2002). "Genetic variation of apolipoproteins in North Indians". Hum. Biol. 74 (5): 673–82.2. van den Elzen P, Garg S, León L, Brigl M, Leadbetter EA, Gumperz JE, Dascher CC, Cheng TY, Sacks FM, Illarionov PA, Besra GS, Kent SC, Moody DB, BrennerMB. (2005). "Apolipoprotein-mediated pathways of lipid antigen presentation.". Nature 437 (7060): 906-10.3. Zhang HL, Wu J, Zhu J (2010). "The Role of Apolipoprotein E in Guillain-Barré Syndrome and Experimental Autoimmune Neuritis". J. Biomed. Biotechnol. 2010: 357412.

COG 133 Preparation Products And Raw materials

Raw materials

Preparation Products

COG 133 Suppliers

Global( 56)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Shanghai Longyu Biotechnology Co., Ltd.	+8619521488211	info@longyupharma.com	China	2542	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30238	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10473	58
Alfa Chemistry		Info@alfa-chemistry.com	United States	24072	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24727	58
Hebei Miaoyin Technology Co.,Ltd	+86-17367732028 +86-17367732028	kathy@hbyinsheng.com	China	3512	58
Zhejiang Hangyu API Co., Ltd	+8617531972939	anna@api-made.com	China	2943	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57505	58
Changsha MOL Changes Biotechnology Co., Ltd.	+8619375158599	info@molchanges.com	China	5223	58

Supplier	Advantage
BOC Sciences	58
Shanghai Longyu Biotechnology Co., Ltd.	58
Career Henan Chemica Co	58
Zhejiang J&C Biological Technology Co.,Limited	58
Alfa Chemistry	58
LEAP CHEM CO., LTD.	58
Hebei Miaoyin Technology Co.,Ltd	58
Zhejiang Hangyu API Co., Ltd	58
Aladdin Scientific	58
Changsha MOL Changes Biotechnology Co., Ltd.	58

COG 133 Spectrum

COG 133(514200-66-9)MS

514200-66-9(COG 133)Related Search:

CARBON MONOXIDE

COG 133 trifluoroacetate salt N-acetyl-L-leucyl-L-arginyl-L-valyl-L-arginyl-L-leucyl-L-alanyl-L-seryl-L-histidyl-L-leucyl-L-arginyl-L-lysyl-L-leucyl-L-arginyl-L-lysyl-L-arginyl-L-leucyl-L-Leucinamide Ac- LRVRLASHLRKLRKRLL-NH2 Ac-Leu-Arg-Val-Arg-Leu-Ala-Ser-His-Leu- Arg-Lys-Leu-Arg-Lys-Arg-Leu-Leu-NH2 apoE(13 COG 133 apoE(133-149) COG-133; COG133 L-Leucinamide, N-acetyl-L-leucyl-L-arginyl-L-valyl-L-arginyl-L-leucyl-L-alanyl-L-seryl-L-histidyl-L-leucyl-L-arginyl-L-lysyl-L-leucyl-L-arginyl-L-lysyl-L-arginyl-L-leucyl- COG 133 TFA salt 514200-66-9 C97H181N37O19 Neuroscience