p-Bromobenzyl Chloroformate
- CAS No.
- 5798-78-7
- Chemical Name:
- p-Bromobenzyl Chloroformate
- Synonyms
- p-Bromobenzyl Chloroformate;4-bromobenzyl carbonochloridate;p-bromobenzyloxycarbonyl chloride;(4-Bromophenyl)methyl Chloroformate;Carbonochloridic acid, (4-bromophenyl)methyl ester
- CBNumber:
- CB92520857
- Molecular Formula:
- C8H6BrClO2
- Molecular Weight:
- 249.49
- MDL Number:
- MFCD17013537
- MOL File:
- 5798-78-7.mol
| Boiling point | 288.3±23.0 °C(Predicted) |
|---|---|
| Density | 1.627±0.06 g/cm3(Predicted) |
| FDA UNII | WOF21NRS5D |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|---|---|
| Signal word | Danger |
| Hazard statements | H315-H318-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P304+P340+P312-P305+P351+P338-P310-P332+P313-P362-P403+P233-P405-P501 |
p-Bromobenzyl Chloroformate price
p-Bromobenzyl Chloroformate Chemical Properties,Uses,Production
Uses
In the preparation of amino acids and peptides.
Application
p-Bromobenzyl Chloroformate is a N-protecting agent for α-amino acids.
Preparation
p-Bromobenzyl Chloroformate may be prepared by the addition of a solution of 4- bromobenzyl alcohol in dioxane to a solution of excess Phosgene in toluene followed by stirring at rt for 24 h. Removal of the solvent by distillation in vacuo at 60 °C leaves a straw-colored oil. Three recrystallizations from hexane at -50 °C gives pure 4-bromobenzyl chloroformate in 78% yield as colorless needles. In a closely related alternate preparative procedure, the crude oily product, obtained in 98% yield, was used in a preparative reaction without further purification.
storage
Although no details are available, the high toxicity and suspected carcinogenic properties of the closely related Benzyl Chloroformate suggest that 4-bromobenzyl chloroformate should be handled with caution.
p-Bromobenzyl Chloroformate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33025 | 60 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Beijing Taiya Jie Technology Development Co., Ltd. | 021-33690831-8001 13552411790 | postmaster@tyjchem.cn | China | 1541 | 55 |
| Nanjing Norris-Pharm Technology Co., Ltd | 13901585132 | 799750417@qq.com | China | 8878 | 55 |
| Shanghai Jian Chao Chemical Technology Co., Ltd. | 18017383231 18017383231 | lyh_antaeus@163.com | China | 9347 | 55 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 18112977050 | cb6@aikonchem.com | China | 16684 | 50 |
| Changzhou Yinghao Technology Development Co., Ltd | 15151934985 | sales@yingsapharm.com | China | 4342 | 58 |
| Shanghai Sunway Pharmaceutical Technology Co.,Ltd. | 021-51816796-820 13611835272 | sales2@sunwaypharm.com | China | 44455 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 62072 | 58 |
| Bide Pharmatech Ltd. | 400-6005915 | sales@picasso-e.com | China | 39665 | 58 |