N-[2-Fluoro-5-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]amino]phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide
![N-[2-Fluoro-5-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]amino]phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide Structure](CAS/GIF/319460-94-1.gif)
- CAS No.
- 319460-94-1
- Chemical Name:
- N-[2-Fluoro-5-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]amino]phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide
- Synonyms
- CS-671;AG 13958;AG-013958;AG13958 ≥95%;AG 13958;AG-13958;AG-13958 (AG-013958);AG-13958, 10 mM in DMSO;(E)-N-(2-Fluoro-5-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)amino)phenyl)-1,3-dimethyl-1H-py;Vascular endothelial growth factor receptor,AG 013958,AG 13958,inhibit,VEGFR,AG13958,AG-13958,Inhibitor,AG013958;(E)-N-(2-Fluoro-5-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)amino)phenyl)-1,3-dimethyl-1H-pyrazole-5-carboxamide
- CBNumber:
- CB92521102
- Molecular Formula:
- C26H22FN7O
- Molecular Weight:
- 467.5
- MDL Number:
- MFCD17017756
- MOL File:
- 319460-94-1.mol
N-[2-Fluoro-5-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]amino]phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide Properties
| Boiling point | 647.8±55.0 °C(Predicted) |
|---|---|
| Density | 1.35±0.1 g/cm3(Predicted) |
| storage temp. | 4°C, protect from light |
| solubility | DMSO: 5 mg/mL (10.70 mM; ultrasonic and warming and heat to 60°C) |
| form | Solid |
| pka | 12.13±0.70(Predicted) |
| color | White to off-white |
| FDA UNII | BK72RP7F7D |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
N-[2-Fluoro-5-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]amino]phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth Carbosynth | FA103515 | AG 13958 | 319460-94-1 | 1mg | $240 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA103515 | AG 13958 | 319460-94-1 | 2mg | $350 | 2021-12-16 | Buy |
| ChemScene | CS-0006794 | AG-13958 99.64% | 319460-94-1 | 5mg | $425 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA103515 | AG 13958 | 319460-94-1 | 5mg | $480 | 2021-12-16 | Buy |
| AK Scientific | SYN1004 | AG13958 | 319460-94-1 | 5mg | $515 | 2021-12-16 | Buy |
N-[2-Fluoro-5-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]amino]phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide Chemical Properties,Uses,Production
Uses
AG-13958 (AG-013958), a potent VEGFR tyrosine kinase inhibitor, is used for treatment of choroidal neovascularization associated with age-related macular degeneration (AMD)[1].
in vivo
ST administration (Steroid injection) of AG-13958 suspension produces a depot of drug on the posterior surface of the sclera that provided sustained exposure to the choroid with little impact on peripheral tissues and no measurable systemic exposure[1].
IC 50
VEGFR
References
[1] M.B. Kosa, et al. Ocular and Systemic Pharmacokinetics of AG-013958 With Sub-Tenon Administration To Cynomologus Monkeys. Investigative Ophthalmology & Visual Science May 2005, Vol.46, 5379.
[2] Solowiej J, et al. Substrate-specific conformational regulation of the receptor tyrosine kinase VEGFR2 catalytic domain. ACS Chem Biol. 2013 May 17;8(5):978-86. DOI:10.1021/cb400040z
N-[2-Fluoro-5-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]amino]phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49732 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38630 | 58 | |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2922 | 55 | |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 12952 | 65 |
| SYN|thesis med chem P/L | +86-021-50720296 | service@synkinase.com | China | 266 | 58 |
| ShangHai YingYi Chemical Technology Co., Ltd. | 86-21-50700185 13764109623 | sale@inyelchem.com | China | 178 | 55 |
