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5-chloro-3-hydroxyisothiazole

CAS No.
25629-58-7
Chemical Name:
5-chloro-3-hydroxyisothiazole
Synonyms
hydroxyisothiazole;5-chloroisothiazol-3-ol;5-Chloro-3-isothiazolol;5-chloroisothiazol-3-one;5-Chloroisothiazol-3(2H)-one;5-Chloro-3(2H)-isothiazolone;5-chloro-3-hydroxyisothiazole;5-Chloro-4-isothiazolin-3-one;3(2H)-Isothiazolone, 5-chloro-;5-chloro-3(2H)-Isothiazolone 97%
CBNumber:
CB92549513
Molecular Formula:
C3H2ClNOS
Molecular Weight:
135.57
MDL Number:
MFCD16658894
MOL File:
25629-58-7.mol
Last updated:2023-10-19 09:55:33

5-chloro-3-hydroxyisothiazole Properties

Melting point 96-97 °C(Solv: water (7732-18-5))
Density 1.62±0.1 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka 7.20±0.40(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H319-H335-H302+H312+H332-H315
Precautionary statements  P280-P301+P312-P302+P352
HS Code  2934100090

5-chloro-3-hydroxyisothiazole price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC B423970 5-chloroisothiazol-3-ol 25629-58-7 10mg $45 2021-12-16 Buy
TRC B423970 5-chloroisothiazol-3-ol 25629-58-7 100mg $240 2021-12-16 Buy
Matrix Scientific 094246 5-Chloroisothiazol-3-ol 95+% 25629-58-7 250mg $385 2021-12-16 Buy
AK Scientific Z4502 5-Chloroisothiazol-3-ol 25629-58-7 1g $440 2021-12-16 Buy
AK Scientific Z4502 5-Chloroisothiazol-3-ol 25629-58-7 100mg $143 2021-12-16 Buy
Product number Packaging Price Buy
B423970 10mg $45 Buy
B423970 100mg $240 Buy
094246 250mg $385 Buy
Z4502 1g $440 Buy
Z4502 100mg $143 Buy

5-chloro-3-hydroxyisothiazole Chemical Properties,Uses,Production

Synthesis

5-chloro-3-hydroxyisothiazole can be synthesized from 3,3'-disulfanediyldipropionic acid and Thionyl chloride in three steps. In particular, in the last step, 5-chloro isothiazolone derivatives (5-chloro-3-hydroxyisothiazole) were the predominant products when the ratio of sulfuryl chloride/amide was 3:1 while with the relevant ratio of 1:1, the 5-unsubstituted analogs were the predominant products[1].5-chloro-3-hydroxyisothiazole

References

[1] Khalaj A, et al. Synthesis and antibacterial activity of 2-(4-substituted phenyl)-3(2H)-isothiazolones. European Journal of Medicinal Chemistry, 2004; 39: 285–290.

1002-19-3
25629-58-7
1003-07-2
Synthesis of 5-chloro-3-hydroxyisothiazole from 3-[(3-AMINO-3-OXOPROPYL)DITHIO]PROPANAMIDE

5-chloro-3-hydroxyisothiazole Preparation Products And Raw materials

Raw materials

Preparation Products

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Amadis Chemical Company Limited
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5-Chloro-3(2H)-isothiazolone 5-Chloro-3-isothiazolol 5-Chloro-4-isothiazolin-3-one 5-chloro-3-hydroxyisothiazole 5-chloroisothiazol-3-ol 3(2H)-Isothiazolone, 5-chloro- 5-chloro-3(2H)-Isothiazolone 97% 5-chloroisothiazol-3-one hydroxyisothiazole 5-Chloroisothiazol-3(2H)-one 25629-58-7 organic building block