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(±)WIN 55212 (mesylate)

(±)WIN 55212 (mesylate) Structure
(±)WIN 55212 (mesylate) structure
CAS No.
137795-17-6
Chemical Name:
(±)WIN 55212 (mesylate)
Synonyms
(±)WIN 55212 (mesylate);FSGCSTPOPBJYSX-UHFFFAOYSA-N
CBNumber:
CB92589823
Molecular Formula:
C28H30N2O6S
Molecular Weight:
522.62
MDL Number:
MOL File:
137795-17-6.mol
Last updated:2023-05-21 10:59:17
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(±)WIN 55212 (mesylate) Properties

storage temp. Store at -20°C
solubility DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH 7.2) (1:2): 0.25 mg/ml; Ethanol: 5 mg/ml; Methanol: 1 mg/ml
form A crystalline solid

(±)WIN 55212 (mesylate) price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 10736 (±)-WIN 55,212 (mesylate) ≥98% 137795-17-6 5mg $41 2024-03-01 Buy
Cayman Chemical 10736 (±)-WIN 55,212 (mesylate) ≥98% 137795-17-6 10mg $78 2024-03-01 Buy
Cayman Chemical 10736 (±)-WIN 55,212 (mesylate) ≥98% 137795-17-6 25mg $183 2024-03-01 Buy
Cayman Chemical 10736 (±)-WIN 55,212 (mesylate) ≥98% 137795-17-6 50mg $322 2024-03-01 Buy
AK Scientific 3559CY Methanesulfonicacid;[2-methyl-11-(morpholin-4-ylmethyl)-9-oxa-1-azatricyclo[6.3.1.04,12]dodeca-2,4(12),5,7-tetraen-3-yl]-naphthalen-1-ylmethanone 137795-17-6 25mg $282 2021-12-16 Buy
Product number Packaging Price Buy
10736 5mg $41 Buy
10736 10mg $78 Buy
10736 25mg $183 Buy
10736 50mg $322 Buy
3559CY 25mg $282 Buy

(±)WIN 55212 (mesylate) Chemical Properties,Uses,Production

Description

(±)-WIN 55,212 is a racemic mixture of the cannabinoid (CB) receptor 1 (CB1) and CB2 agonist (+)-WIN 55,212-2 and the CB2 neutral antagonist (?)-WIN 55,212-3 .1 It inhibits electrically induced contractions in mouse vas deferens preparations (IC50 = 0.006 μM) and reduces prostaglandin (PG) synthesis by 35% in mouse brain microsomes when used at a concentration of 30 μM.2 (±)-WIN 55,212 decreases acetylcholine-induced writhing in mice with an ED50 value of 0.25 mg/kg. It induces hypolocomotion, analgesia, hypothermia, and catalepsy in mice (ED50s = 1.09, 0.5, 3.01 and 6.8 mg/kg, respectively).3

References

1. Savinainen, J.R., Kokkola, T., Salo, O.M.H., et al. Identification of WIN55212-3 as a competitive neutral antagonist of the human cannabinoid CB2 receptor Br. J. Pharmacol. 145,636-645(2005).
2. D'Ambra, T.E., Estep, K.G., Bell, M.R., et al. Conformationally restrained analogues of pravadoline: Nanomolar potent, enantioselective, (aminoalkyl)indole agonists of the cannabinoid receptor J. Med. Chem. 35,124-135(1992).
3. Fan, F., Compton, D.R., Ward, S., et al. Development of cross-tolerance between Δ9-tetrahydrocannabinol, CP 55,940 and WIN 55,212 J. Pharmacol. Exp. Ther. 271(3),1383-1390(1994).

(±)WIN 55212 (mesylate) Preparation Products And Raw materials

Raw materials

Preparation Products

(±)WIN 55212 (mesylate) Suppliers

Global( 6)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9707 58
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6870 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 28091 58
Supplier Advantage
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai Hongye Biotechnology Co. Ltd 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
TargetMol Chemicals Inc. 58
(±)WIN 55212 (mesylate) FSGCSTPOPBJYSX-UHFFFAOYSA-N 137795-17-6