Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>Pyrrophenone

Pyrrophenone

Pyrrophenone Structure
Pyrrophenone structure
CAS No.
341973-06-6
Chemical Name:
Pyrrophenone
Synonyms
Pyrrophenone;N-[[(2S,4R)-1-[2-(2,4-difluorobenzoyl)benzoyl]-4-tritylsulfanylpyrrolidin-2-yl]methyl]-4-[(E)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]benzamide;Benzamide, N-[[(2S,4R)-1-[2-(2,4-difluorobenzoyl)benzoyl]-4-[(triphenylmethyl)thio]-2-pyrrolidinyl]methyl]-4-[(Z)-(2,4-dioxo-5-thiazolidinylidene)methyl]-
CBNumber:
CB92592322
Molecular Formula:
C49H37F2N3O5S2
Molecular Weight:
849.962
MDL Number:
MFCD18384946
MOL File:
341973-06-6.mol
Last updated:2024-07-02 08:55:41
Request For Quotation

Pyrrophenone Properties

storage temp. Store at -20°C
solubility DMF: 12.5 mg/ml; DMSO: 15 mg/ml; DMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml
form A crystalline solid
color White to off-white

Pyrrophenone price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 13294 Pyrrophenone ≥95% 341973-06-6 500μg $122 2024-03-01 Buy
Cayman Chemical 13294 Pyrrophenone ≥95% 341973-06-6 1mg $231 2024-03-01 Buy
Cayman Chemical 13294 Pyrrophenone ≥95% 341973-06-6 5mg $911 2024-03-01 Buy
Cayman Chemical 13294 Pyrrophenone ≥95% 341973-06-6 10mg $1700 2024-03-01 Buy
AK Scientific 2021AH Pyrrophenone 341973-06-6 10mg $1857 2021-12-16 Buy
Product number Packaging Price Buy
13294 500μg $122 Buy
13294 1mg $231 Buy
13294 5mg $911 Buy
13294 10mg $1700 Buy
2021AH 10mg $1857 Buy

Pyrrophenone Chemical Properties,Uses,Production

Description

The group IVA phospholipase A2 (PLA2), known as calcium-dependent cytosolic PLA2 (cPLA2), selectively releases arachidonic acid (AA) from membrane phospholipids, playing a central role in initiating the synthesis of prostaglandins (PGs) and leukotrienes (LTs). Pyrrophenone inhibits cPLA2α with an IC50 of 4.2 nM in enzyme assays and potently blocks the release of AA and the production of PGE2 and LTC4 in cells (IC50 = 24, 25, and 14 nM, respectively). Its action is reversible and selective, as pyrrophenone inhibits the secretory type IB and IIA PLA2s with more than a hundred-fold less potency. Pyrrophenone has also been shown to inhibit calcium ionophore (A23187)-stimulated AA release from monocytic cells, interleukin-1-induced PGE2 synthesis in mesangial cells, and the production of PGE2, LTs, and platelet-activating factor by human neutrophils, always with maximal inhibition at concentrations below 1 μM.

Pyrrophenone Preparation Products And Raw materials

Raw materials

Preparation Products

Pyrrophenone Suppliers

Global( 11)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6870 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 order@med-bio.cn China 8141 58
Shanghai Universal Biotech Co.,Ltd 13774214275 gaojun@univ-bio.com China 24990 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24647 58
Shanghai Tachizaki Biomedical Research Center 18014399201 sales@chemlab-tachizaki.com China 2550 58
Nanjing Tengyi Biotechnology Co., Ltd 025-58851786 17714337195 sales@tybiochem.com China 7418 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11975 58
RD International Technology Co., Limited 18024082417 market@ubiochem.com China 9268 58
Supplier Advantage
Shanghai Hongye Biotechnology Co. Ltd 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
MedBioPharmaceutical Technology Inc 58
Shanghai Universal Biotech Co.,Ltd 58
TargetMol Chemicals Inc. 58
Shanghai Tachizaki Biomedical Research Center 58
Nanjing Tengyi Biotechnology Co., Ltd 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
RD International Technology Co., Limited 58
Pyrrophenone N-[[(2S,4R)-1-[2-(2,4-difluorobenzoyl)benzoyl]-4-tritylsulfanylpyrrolidin-2-yl]methyl]-4-[(E)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]benzamide Benzamide, N-[[(2S,4R)-1-[2-(2,4-difluorobenzoyl)benzoyl]-4-[(triphenylmethyl)thio]-2-pyrrolidinyl]methyl]-4-[(Z)-(2,4-dioxo-5-thiazolidinylidene)methyl]- 341973-06-6 C49H37F2N3O5S2