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ENMD-2076 (Tartrate)

CAS No.
1291074-87-7
Chemical Name:
ENMD-2076 (Tartrate)
Synonyms
ENMD-2076 (Tartrate);ENMD-2076 L-(+)-Tartaric acid;ENMD-2076 tartrate (ENMD 2076;(E)-N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-1-yl)-2-styrylpyrimidin-4-amine,L-(+)-Tartaric acid
CBNumber:
CB92624137
Molecular Formula:
C21H25N7.x(C4H6O6)
Molecular Weight:
0
MDL Number:
MFCD18074523
MOL File:
Mol file
Last updated:2023-05-21 10:59:17

ENMD-2076 (Tartrate) Properties

storage temp. Store at -20°C
solubility insoluble in EtOH; ≥175.8 mg/mL in DMSO
form solid

ENMD-2076 (Tartrate) price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ApexBio Technology A4129 ENMD-2076L-(+)-Tartaricacid 1291074-87-7 5mg $50 2021-12-16 Buy
ChemScene CS-0210 ENMD-2076Tartrate 98.87% 1291074-87-7 5mg $120 2021-12-16 Buy
ApexBio Technology A4129 ENMD-2076L-(+)-Tartaricacid 1291074-87-7 50mg $120 2021-12-16 Buy
ChemScene CS-0210 ENMD-2076Tartrate 98.87% 1291074-87-7 10mg $180 2021-12-16 Buy
Biorbyt Ltd orb611816 ENMD-2076 tartrate 1291074-87-7 10mg $210.8 2021-12-16 Buy
Product number Packaging Price Buy
A4129 5mg $50 Buy
CS-0210 5mg $120 Buy
A4129 50mg $120 Buy
CS-0210 10mg $180 Buy
orb611816 10mg $210.8 Buy

ENMD-2076 (Tartrate) Chemical Properties,Uses,Production

Uses

ENMD-2076 (ENMD-981693, ENMD2076) is a antiangiogenic and Aurora kinase inhibitor with IC50 of 3, 13, 350, 23, 40, 93 and 120 nM for Flt-3, AurA, AurB, Src, KDR/VEGFR2 and FGFR1.

Biological Activity

enmd-2076 is an orally bioavailable, small molecule inhibitor of aurora kinases with ic50 values of 14nm and 350nm, respectively against aurora kinase a and aurora kinase b [1].besides aurora kinases, enmd-2076 inhibits multiple kinases involved in various cellular activities. overexpression of aurora kinase a has been found in breast cancers and enmd-2076 is thereby studied in breast cancers. it is reported that enmd-2076 differentially inhibits 29 breast cancer cell lines with ic50 values ranged from 0.25 to 16.1μm. in the clonogenic assays, enmd-2076 totally suppresses the colony formation in the sensitivemda-mb-468 cell line and decreases the formation in thehcc1806, sk-br-3, and bt474 cell lines. enmd-2076 is also reported to cause a g2 cell-cycle arrest at 1.25μm. moreover, enmd-2076 shows antitumor activity in tnbc xenograft models. apart from the breast cancers, enmd-2076 is developed in hematological malignancies therapy. the

References

[1] diamond jr, eckhardt sg, tan ac, newton tp, selby hm, brunkow kl, kachaeva mi, varella-garcia m, pitts tm, bray mr, fletcher gc, tentler jj. predictive biomarkers of sensitivity to the aurora and angiogenic kinase inhibitor enmd-2076 in preclinical breast cancer models. clin cancer res. 2013 jan 1;19(1):291-303.
[2] how j, yee k. enmd-2076 for hematological malignancies. expert opin investig drugs. 2012 may;21(5):717-32.

ENMD-2076 (Tartrate) Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 78)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86-(0)57185586718 +86-13336195806 sales@capot.com China 29791 60
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28172 58
Career Henan Chemica Co
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HANGZHOU CLAP TECHNOLOGY CO.,LTD
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InvivoChem
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TargetMol Chemicals Inc.
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Wuhan Topule Biopharmaceutical Co., Ltd
+8618327326525 masar@topule.com China 8467 58
Shanghai Acmec Biochemical Technology Co., Ltd.
+undefined18621343501 product@acmec-e.com China 33338 58
Aladdin Scientific
+1-+1(833)-552-7181 sales@aladdinsci.com United States 57505 58
SHANGHAI KEAN TECHNOLOGY CO., LTD.
+8613817748580 cooperation@kean-chem.com China 40066 58

ENMD-2076 (Tartrate) Spectrum

1291074-87-7(ENMD-2076 (Tartrate))Related Search:

(E)-N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-1-yl)-2-styrylpyrimidin-4-amine,L-(+)-Tartaric acid ENMD-2076 (Tartrate) ENMD-2076 L-(+)-Tartaric acid ENMD-2076 tartrate (ENMD 2076 1291074-87-7 291074-87-7 C21H25N7xC4H6O6 C25H31N7O6 Inhibitors Inhibitor