NBD-556
- CAS No.
- 333353-44-9
- Chemical Name:
- NBD-556
- Synonyms
- NBD-556;NBD-556;NBD 556; NBD556;N-(4-Chlorophenyl)-N'-(2,2,6,6-tetramethylpiperidin-4-yl)oxalamide;N1-(4-Chlorophenyl)-N2-(2,2,6,6-tetramethylpiperidin-4-yl)oxalamide;N1-(4-Chlorophenyl)-N2-(2,2,6,6-tetramethyl-4-piperidinyl)-ethanediamide;Ethanediamide, N1-(4-chlorophenyl)-N2-(2,2,6,6-tetramethyl-4-piperidinyl)-;inhibit,HIV-1,fusion,virus-cell,Human immunodeficiency virus,NBD556,HIV,Inhibitor,gp120,CD4,NBD 556,NBD-556,mimetic
- CBNumber:
- CB92624263
- Molecular Formula:
- C17H24ClN3O2
- Molecular Weight:
- 337.84
- MDL Number:
- MFCD00469538
- MOL File:
- 333353-44-9.mol
- MSDS File:
- SDS
NBD-556 price More Price(22)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | SML0812 | NBD-556 ≥98% (HPLC) | 333353-44-9 | 5mg | $95.2 | 2024-03-01 | Buy |
Sigma-Aldrich | SML0812 | NBD-556 ≥98% (HPLC) | 333353-44-9 | 25mg | $482 | 2024-03-01 | Buy |
TCI Chemical | N1090 | NBD-556 >98.0%(HPLC) | 333353-44-9 | 25mg | $261 | 2024-03-01 | Buy |
TCI Chemical | N1090 | NBD-556 >98.0%(HPLC) | 333353-44-9 | 100mg | $718 | 2024-03-01 | Buy |
Cayman Chemical | 21274 | NBD-556 ≥98% | 333353-44-9 | 1mg | $32 | 2024-03-01 | Buy |
NBD-556 Chemical Properties,Uses,Production
Uses
NBD-556 is a N-phenyl-N''-(2,2,6,6-tetramethyl-piperidin-4-yl)-oxalamide analog, a novel class of human immunodeficiency virus type 1 (HIV-1) entry inhibitors that block the gp120-CD4 interaction.
Uses
NBD-556 is a N-phenyl-N'-(2,2,6,6-tetramethyl-piperidin-4-yl)-oxalamide analog, a novel class of human immunodeficiency virus type 1 (HIV-1) entry inhibitors that block the gp120-CD4 interaction.
Biological Activity
the entry of hiv-1 into host cells is mediated by the binding of the surface subunit gp120 to the host cell receptor cd4. nbd-556 is a novel class of human immunodeficiency virus type 1 (hiv-1) entry inhibitor that block the gp120–cd4 interaction with drug-like properties.
in vitro
a systematic study showed that nbd-556 and nbd-557 target viral entry by inhibiting the binding of hiv-1 envelope glycoprotein gp120 to the cellular receptor cd4 but did not inhibit reverse transcriptase, protease, or integrase, demonstrating that they do not target the later stages of the hiv-1 life cycle to inhibit hiv-1 infection. nbd-556 and nbd-557 were also active against hiv-1 laboratory-adapted strains including an azt-resistant strain and hiv-1 primary isolates, showing that these compounds can potentially be further modified to become potent hiv-1 entry inhibitors [1].
IC 50
nbd-556 inhibited cell–cell fusion between h9/hiv-1iiib and mt-2 (ic50 ~3 μm)
References
[1] zhao, q. , l. ma, s. jiang, h. lu, s. liu, y. he, n. strick, n. neamati, and a. k. debnath. 2005. identification of n-phenyl-n′-(2,2,6,6-tetramethyl-piperidin-4-yl)-oxalamides as a new class of hiv-1 entry inhibitors that prevent gp120 binding to cd4. virology 339:213-225.
NBD-556 Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94658 | 76 |
Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 6008 | 61 |
Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28398 | 80 |
TCI Europe | 320-37350700 | sales@tcieurope.eu | Europe | 23680 | 75 |
TCI AMERICA | 800-4238616 | sales@tciamerica.com | Americas | 23662 | 75 |
Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-400-6206333 18521732826 | market@aladdin-e.com | China | 25013 | 65 |