A-443654
- CAS No.
- 552325-16-3
- Chemical Name:
- A-443654
- Synonyms
- A-443654;A-443654;A443654;A-443654, 10 mM in DMSO;inhibit,A443654,A-443654,Inhibitor,PKB,Akt,A 443654,Protein kinase B;(2S)-1-(1H-indol-3-yl)-3-[5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxypropan-2-amine;1H-Indole-3-ethanamine, α-[[[5-(3-methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]-, (αS)-;1H-Indole-3-ethanaMine, a-[[[5-(3-Methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]Methyl]-, (aS)-;(alphaS)-alpha-[[[5-(3-Methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]-(S)-1H-indole-3-ethanamine
- CBNumber:
- CB92627239
- Molecular Formula:
- C24H23N5O
- Molecular Weight:
- 397.47
- MDL Number:
- MFCD11840663
- MOL File:
- 552325-16-3.mol
- MSDS File:
- SDS
A-443654 price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 16499 | A-443654 ≥98% | 552325-16-3 | 500μg | $68 | 2024-03-01 | Buy |
| Cayman Chemical | 16499 | A-443654 ≥98% | 552325-16-3 | 1mg | $109 | 2024-03-01 | Buy |
| Cayman Chemical | 16499 | A-443654 ≥98% | 552325-16-3 | 5mg | $401 | 2024-03-01 | Buy |
| American Custom Chemicals Corporation | INB0001420 | A-443654 95.00% | 552325-16-3 | 5MG | $503.87 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611401 | A-443654 | 552325-16-3 | 5mg | $569.5 | 2021-12-16 | Buy |
A-443654 Chemical Properties,Uses,Production
Uses
A-443654 is a pan-Akt inhibitor and has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM)[1].
Definition
ChEBI: (2S)-1-(1H-indol-3-yl)-3-[[5-(3-methyl-2H-indazol-5-yl)-3-pyridinyl]oxy]-2-propanamine is a member of indoles.
in vivo
A-443654 (7.5 mg/kg/d, s.c.) inhibits tumor growth in the 3T3-Akt1 flank tumor model. A-443654 (50 mg/kg, s.c.) induces apoptosis in 3T3-Akt1 flank tumors. A-443654 (30 mg/kg, s.c.) leads to increased levels of phosphorylated Akt1 in MiaPaCa-2 tumors[1].
target
Akt1
IC 50
Akt1: 160 pM (Ki); Akt2: 160 pM (Ki); Akt3: 160 pM (Ki); PKA: 6.3 nM (Ki); RSK2: 11 nM (Ki); PKCγ: 24 nM (Ki); CDK2: 24 nM (Ki); PKCδ: 33 nM (Ki); GSK3β: 41 nM (Ki); ERK2: 340 nM (Ki); cKIT: 1.2 μM (Ki); Chk1: 2.3 μM (Ki); CK2: 2.4 μM (Ki); SRC: 2.6 μM (Ki); KDR: 3.1 μM (Ki); MAPK-AP2: 3.3 μM (Ki); Flt1: 3.6 μM (Ki)
References
[1] Luo Y, et al. Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo. Mol Cancer Ther. 2005 Jun;4(6):977-86. DOI:10.1158/1535-7163.MCT-05-0005
[2] Zheng J, et al. Rapamycin sensitizes Akt inhibition in malignant human breast epithelial cells. Cancer Lett. 2010 Oct 1;296(1):74-87. DOI:10.1016/j.canlet.2010.03.018
[3] Gallia GL, et al. Inhibition of Akt inhibits growth of glioblastoma and glioblastoma stem-like cells. Mol Cancer Ther. 2009 Feb;8(2):386-93. DOI:10.1158/1535-7163.MCT-08-0680
[4] Zhao Y, et al. Estrogen receptor alpha and beta regulate actin polymerization and spatial memory through an SRC-1/mTORC2-dependent pathway in the hippocampus of female mice. J Steroid Biochem Mol Biol. 2017 Nov;174:96-113. DOI:10.1016/j.jsbmb.2017.08.003
A-443654 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29859 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 15319487004 | 1015@dideu.com | China | 3978 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| Chemtour Biotech Co., Ltd | +8617327281506 | market@chemtour.com | China | 1521 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| DONBOO AMINO ACID COMPANY | +8618051385538 | donboo@donboo.com | China | 9363 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 12952 | 65 |
