DG 051 (HCl salt)
- CAS No.
- 929915-58-2
- Chemical Name:
- DG 051 (HCl salt)
- Synonyms
- DG051;DG051 (DG-051;DG 051 (HCl salt);DG051,Aminopeptidase,inhibit,DG 051,Inhibitor,DG-051;(2S)-2-[[4-(4-Chlorophenoxy)phenoxy]methyl]-1-pyrrolidinebutanoic Acid Hydrochloride;4-((S)-2-((4-(4-chlorophenoxy)phenoxy)Methyl)pyrrolidin-1-yl)butanoic acid hydrochloride
- CBNumber:
- CB92627754
- Molecular Formula:
- C21H25Cl2NO4
- Molecular Weight:
- 426.3335
- MDL Number:
- MFCD18251532
- MOL File:
- 929915-58-2.mol
storage temp. | Store at -20°C |
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solubility | DMF: 20 mg/ml; DMSO: 12.5 mg/ml; Ethanol: 12.5 mg/ml; PBS (pH 7.2): 2 mg/ml |
form | Solid |
color | White to light yellow |
FDA UNII | 28B7Y5Y8EF |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() ![]() GHS02,GHS07 |
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Signal word | Danger | |||||||||
Hazard statements | H225-H319 | |||||||||
Precautionary statements | P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P337+P313-P370+P378-P403+P235-P501 | |||||||||
NFPA 704 |
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DG 051 (HCl salt) price More Price(14)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 21688 | DG-051 ≥98% | 929915-58-2 | 1mg | $32 | 2024-03-01 | Buy |
Cayman Chemical | 21688 | DG-051 ≥98% | 929915-58-2 | 5mg | $139 | 2024-03-01 | Buy |
Cayman Chemical | 21688 | DG-051 ≥98% | 929915-58-2 | 10mg | $243 | 2024-03-01 | Buy |
Cayman Chemical | 21688 | DG-051 ≥98% | 929915-58-2 | 25mg | $533 | 2024-03-01 | Buy |
TRC | C381365 | (2S)-2-[[4-(4-Chlorophenoxy)phenoxy]methyl]-1-pyrrolidinebutanoicAcidHydrochloride | 929915-58-2 | 100mg | $1365 | 2021-12-16 | Buy |
DG 051 (HCl salt) Chemical Properties,Uses,Production
Description
DG-051 is a potent, orally bioavailable leukotriene A4 hydrolase (LTA4H) inhibitor (Kd = 25 nM; IC50 = 47 nM), the enzyme that catalyzes the rate-determining step in the synthesis of LTB4 . However, it also inhibits the aminopeptidase activity of LTA4H with IC50 values of 72 and 150 nM when tested using the substrates L-alanine p-nitroanaline and prolyl-glycyl-proline peptide (PGP; ), respectively, potentially leading to PGP accumulation in vivo. DG-051 does not show any inhibitory activity against a panel of more than 50 additional aminopeptidases, ion channels, or HERG.
Uses
(2S)?-2-?[[4-?(4-Chlorophenoxy)?phenoxy]?methyl]?-1-?pyrrolidinebutanoic Acid Hydrochloride is a potent inhibitor leukotriene A4 hydrolase (LTA4H), which is a therapeutic target for developing treatments for cardiovascular diseases and cancers.
DG 051 (HCl salt) Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29894 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
Shanghai ChuangYan Chemical Technology Co., Ltd. | 021-11111111 11111111111 | 546919421@qq.com | China | 3067 | 55 |
BOC Sciences | 16314854226 | info@bocsci.com | United States | 9926 | 65 |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9707 | 58 |
Musechem | +1-800-259-7612 | info@musechem.com | United States | 4662 | 60 |
Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9730 | 58 |
DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9412 | 58 |
Beijing xinyanhui pharmaceutical research and development co., LTD | 13969155946 | 1461866103@qq.com | China | 16111 | 58 |
View Lastest Price from DG 051 (HCl salt) manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
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2019-07-06 | DG 051 (HCl salt)
929915-58-2
|
US $1.00 / KG | 1KG | 96% | 500kg | Career Henan Chemical Co |
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- DG 051 (HCl salt)
929915-58-2
- US $1.00 / KG
- 96%
- Career Henan Chemical Co