Carbonic Anhydrase IX/XII Inhibitor II(U-104)
- CAS No.
- 178606-66-1
- Chemical Name:
- Carbonic Anhydrase IX/XII Inhibitor II(U-104)
- Synonyms
- U-104;DNAJA4;MSTP104;PRO1472;CS-1653;MST-104 ;SLC-0111;NSC 213841;U-104, >98%;U104(SLC-0111)
- CBNumber:
- CB92630071
- Molecular Formula:
- C13H12FN3O3S
- Molecular Weight:
- 309.32
- MDL Number:
- MFCD00159265
- MOL File:
- 178606-66-1.mol
- MSDS File:
- SDS
Melting point | 242-243℃ |
---|---|
Density | 1.523±0.06 g/cm3 (20 ºC 760 Torr) |
storage temp. | 2-8°C |
solubility | DMSO: >15mg/mL |
form | powder |
pka | 9.94±0.12(Predicted) |
color | white to beige |
FDA UNII | ANM9DBL9JT |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302-H315-H320-H335 | |||||||||
Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
Hazard Codes | Xi | |||||||||
Risk Statements | 36 | |||||||||
Safety Statements | 26 | |||||||||
WGK Germany | 3 | |||||||||
NFPA 704 |
|
Carbonic Anhydrase IX/XII Inhibitor II(U-104) price More Price(37)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | SML0374 | U-104 ≥98% (HPLC) | 178606-66-1 | 5mg | $117 | 2024-03-01 | Buy |
Sigma-Aldrich | SML0374 | U-104 ≥98% (HPLC) | 178606-66-1 | 25mg | $458 | 2024-03-01 | Buy |
Sigma-Aldrich | HPA041790 | Anti-DNAJA4 antibody produced in rabbit Prestige Antibodies? Powered by Atlas Antibodies, affinity isolated antibody | 100μL | $580 | 2024-03-01 | Buy | |
Sigma-Aldrich | 215901 | Carbonic Anhydrase IX/XII Inhibitor II, U-104 The Carbonic Anhydrase IX/XII Inhibitr II, U-104 controls the biological activity of Carbonic Anhydrase IX/XII. This small molecule/inhibitor is primarily used for Cancer applications. | 5MG | $130 | 2024-03-01 | Buy | |
Sigma-Aldrich | HPA041790 | Anti-DNAJA4 antibody produced in rabbit Prestige Antibodies? Powered by Atlas Antibodies, affinity isolated antibody | 25μL | $282 | 2023-06-20 | Buy |
Carbonic Anhydrase IX/XII Inhibitor II(U-104) Chemical Properties,Uses,Production
Uses
U 104 targets hypoxia-induced carbonic anhydrase IX, which inhibits tumor growth and metastasis.
Biological Activity
u-104 is a novel ureido-sulfonamide inhibitor of carbonic anhydrase ix (caix). tumor volume measurements show important inhibition of primary tumor growth in the mice treated with the u-104 compound compared with vehicle controls. it also has ability to inhibit metastasis formation in the 4t1 experimental metastasis model.yuanmei lou, paul c. mcdonald, arusha oloumi, stephen chia, christina ostlund, ardalan ahmadi, alastair kyle, ulrich auf dem keller, samuel leung, david huntsman, blaise clarke, brent w. sutherland, dawn waterhouse, marcel bally, calvin roskelley, christopher m. overall, andrew minchinton, fabio pacchiano, fabrizio carta, andrea scozzafava, nadia touisni, jean-yves winum, claudiu t. supuran, shoukat dedhar. targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase ix inhibitors. cancer research may 1, 2011 71; 3364
Biochem/physiol Actions
U-104 is an inhibitor of CA IX that binds only to CA IX under hypoxic conditions in vivo. The binding results in significant inhibition of tumor growth and metastasis formation in both spontaneous and experimental models of metastasis. U-104 reduces the medium acidity by inhibiting the catalytic activity of the CA IX. It binds specifically only to hypoxic cells expressing CA IX.
Carbonic Anhydrase IX/XII Inhibitor II(U-104) Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29898 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 25022 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
View Lastest Price from Carbonic Anhydrase IX/XII Inhibitor II(U-104) manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2019-09-06 | Carbonic Anhydrase IX/XII Inhibitor II(U-104)
178606-66-1
|
US $1.00 / KG | 1KG | 98% | 20kg | Career Henan Chemical Co |
- Carbonic Anhydrase IX/XII Inhibitor II(U-104)
178606-66-1
- US $1.00 / KG
- 98%
- Career Henan Chemical Co