Doxofylline
- CAS No.
- 69975-86-6
- Chemical Name:
- Doxofylline
- Synonyms
- DOXOPHYLLINE;ventax;abc12/3;ansimar;Ansirnar;MAXIVENT;ABC 1213;DOXOFYLLINE;Doxofyliine;Doxof3rlline
- CBNumber:
- CB9265231
- Molecular Formula:
- C11H14N4O4
- Molecular Weight:
- 266.25
- MDL Number:
- MFCD00865218
- MOL File:
- 69975-86-6.mol
- MSDS File:
- SDS
| Melting point | 144-146°C |
|---|---|
| Boiling point | 409.46°C (rough estimate) |
| Density | 1.2896 (rough estimate) |
| refractive index | 1.6000 (estimate) |
| RTECS | XH5135000 |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 0.42±0.70(Predicted) |
| color | White to Off-White |
| Water Solubility | Soluble |
| Merck | 14,3438 |
| InChI | InChI=1S/C11H14N4O4/c1-13-9-8(10(16)14(2)11(13)17)15(6-12-9)5-7-18-3-4-19-7/h6-7H,3-5H2,1-2H3 |
| InChIKey | HWXIGFIVGWUZAO-UHFFFAOYSA-N |
| SMILES | N1(CC2OCCO2)C2=C(N(C)C(=O)N(C)C2=O)N=C1 |
| CAS DataBase Reference | 69975-86-6(CAS DataBase Reference) |
| FDA UNII | MPM23GMO7Z |
| ATC code | R03DA11 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312+P330-P501-P301+P312a-P330-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36/37 | |||||||||
| HS Code | 29399990 | |||||||||
| Toxicity | LD50 in mice (mg/kg): 841 orally; 215.6 i.v.; in rats: 1022.4 orally, 445 i.p. (Franzone) | |||||||||
| NFPA 704 |
|
Doxofylline price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | D4302 | Doxofylline >98.0%(HPLC)(T) | 69975-86-6 | 1g | $36 | 2024-03-01 | Buy |
| TCI Chemical | D4302 | Doxofylline >98.0%(HPLC)(T) | 69975-86-6 | 25g | $152 | 2024-03-01 | Buy |
| Alfa Aesar | J60575 | Doxofylline | 69975-86-6 | 5g | $129.65 | 2024-03-01 | Buy |
| Cayman Chemical | 18746 | Doxofylline ≥98% | 69975-86-6 | 1g | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 18746 | Doxofylline ≥98% | 69975-86-6 | 5g | $139 | 2024-03-01 | Buy |
Doxofylline Chemical Properties,Uses,Production
Description
Doxofylline, a xanthine bronchodilator related to theophylline, is useful in the treatment of asthma and similar bronchospastic disorders. It has minimal activity on intestinal smooth muscle and the cardiovascular system, and is reportedly devoid of the behavioral effects of theophylline.
Description
Doxofylline is a methylxanthine bronchodilator that has been examined in clinical trials involving patients with either bronchial asthma or chronic obstructive pulmonary disease. Its mechanism of action is related to its ability to inhibit phosphodiesterase activity and, thus, increase cAMP. Compared to other xanthine derivatives, which have direct arrhythmogenic effects, doxofylline demonstrates decreased affinity towards adenosine A1 and A2 receptors, does not interfere with calcium influx into cells, and does not antagonize the action of calcium-channel blockers.
Originator
ABC S.p.A. (Italy)
Uses
H1 antihistamine
Uses
Doxofylline is a xanthine molecule that appears to be both bronchodilator and anti-inflammatory with an improved therapeutic window over conventional xanthines such as Theophylline and the evidence supporting the effects of Doxofylline in the treatment of lung diseases.
Definition
ChEBI: Doxofylline is an oxopurine that is a derivative of xanthine, methylated at N-1 and N-3 and carrying a 1,3-dioxolan-2-ylmethyl group at N-7, used in the treatment of asthma. It has a role as a bronchodilator agent, an antitussive and an anti-asthmatic drug. It is functionally related to a 7H-xanthine.
brand name
Maxivent (Roberts Pharmaceutical);ANSIMAR.
Doxofylline Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Weibang Biotechnology Co., Ltd | +8615531157085 | abby@weibangbio.com | China | 8812 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2472 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20287 | 58 |
| HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | +86-15350851019 +86-15383190639 | admin@86-ss.com | China | 1000 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| Hubei XinRunde Chemical Co., Ltd. | +8615102730682 | bruce@xrdchem.cn | CHINA | 566 | 55 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +8618949832763 | info@tnjchem.com | China | 2986 | 55 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29884 | 58 |
| Jinan Shengqi pharmaceutical Co,Ltd | 86+18663751872 | christine@shengqipharm.com | CHINA | 491 | 58 |
View Lastest Price from Doxofylline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-24 | Doxofylline
69975-86-6
|
US $100.00-75.00 / kg | 1kg | 99% | 5000Ton | HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | |
 |
2024-11-19 | Doxofylline
69975-86-6
|
US $33.00-48.00 / mg | 99.98% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-11-19 | Doxofylline
69975-86-6
|
US $33.00-48.00 / mg | 99.98% | 10g | TargetMol Chemicals Inc. |
-
- Doxofylline
69975-86-6
- US $100.00-75.00 / kg
- 99%
- HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
-
- Doxofylline
69975-86-6
- US $33.00-48.00 / mg
- 99.98%
- TargetMol Chemicals Inc.
-
- Doxofylline
69975-86-6
- US $33.00-48.00 / mg
- 99.98%
- TargetMol Chemicals Inc.