AMbroxol-d5 HCl
- CAS No.
- 1246818-80-3
- Chemical Name:
- AMbroxol-d5 HCl
- Synonyms
- Ambroxol-d5;AMbroxol-d5 HCl;Ambroxol D5 DISCONTINUED, offer A575902
- CBNumber:
- CB92673463
- Molecular Formula:
- C13H18Br2N2O
- Molecular Weight:
- 378.11
- MDL Number:
- MOL File:
- 1246818-80-3.mol
AMbroxol-d5 HCl Chemical Properties,Uses,Production
Biological Activity
Ambroxol-d5 is intended for use as an internal standard for the quantification of ambroxol by GC- or LC-MS. Ambroxol is an expectorant and active metabolite of bromhexine.1 It decreases short-circuit currents in electrically stimulated isolated canine tracheal epithelial cells when applied submucosally (IC50 = 60 nM).2 Ambroxol (100 μM) decreases IL-13-induced production of mucin 5AC (MUC5AC) in primary human airway epithelial cells and inhibits IL-13-induced decreases in the mucociliary transport rate of endogenous particles in the same cells.3 Ambroxol increases phenol red secretion, a marker of expectorant activity, in mice when administered at doses of 30, 60, or 120 mg/kg.4 Formulations containing ambroxol have been used in the treatment of acute or chronic respiratory conditions.
References
1.Malerba, M., and Ragnoli, B.Ambroxol in the 21st century: Pharmacological and clinical updateExpert Opin. Drug Metab. Toxicol.4(8)1119-1129(2008) 2.Tamaoki, J., Chiyotani, A., Yamauchi, F., et al.Ambroxol inhibits Na+ absorption by canine airway epithelial cells in cultureJ. Pharm. Pharmacol.43(12)841-843(1991) 3.Seagrave, J., Albrecht, H.H., Hill, D.B., et al.Effects of guaifenesin, N-acetylcysteine, and ambroxol on MUC5AC and mucociliary transport in primary differentiated human tracheal-bronchial cellsRespir. Res.13(1)98(2012) 4.Menezes, P.M.N., Brito, M.C., Sousa de Sá, P.G., et al.Analytical and pharmacological validation of the quantification of phenol red in a mouse model: An optimized method to evaluate expectorant drugsJ. Pharmacol. Toxicol. Methods98106586(2019)
AMbroxol-d5 HCl Preparation Products And Raw materials
Raw materials
Preparation Products
AMbroxol-d5 HCl Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shenzhen Regent Biochemical Technology Co., Ltd. | 0755-0755-85201366 18938635012 | sales@regentsciences.com | China | 9301 | 58 |
| Hefei Molake Biotechnology Co., Ltd. | 0551-66336380 18956014586 | 983438788@qq.com | China | 2103 | 58 |
| ChemeGen 中国 | 18818260767 | sales@chemegen.com | China | 6975 | 58 |
| Shanghai Yiyan Biotechnology Co. , Ltd. | 021-69985186 13611928337 | 3427709316@qq.com | China | 7984 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8739 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 17301488900 | judy.xia@synzest.com | China | 12584 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 28118 | 58 |
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