Marinopyrrole A
- CAS No.
- 1227962-62-0
- Chemical Name:
- Marinopyrrole A
- Synonyms
- )-MARINOPYRROLE A;(±)-Marinopyrrole A;Maritoclax, 10 mM in DMSO;Marinopyrrole A(Maritoclax);Maritoclax, (±)-Marinopyrrole A;(+/-)-Marinopyrrole A >=95% (HPLC);Inhibitor,Maritoclax,Bcl-2 Family,inhibit;(4,4',5,5'-Tetrachloro-1'H-[1,3'-bipyrrole]-2,2'-diyl)bis((2-hydroxyphenyl)methanone);1,1'-(4,4',5,5'-Tetrachloro[1,3'-bi-1H-pyrrole]-2,2'-diyl)bis[1-(2-hydroxyphenyl)methanone];Methanone, 1,1'-(4,4',5,5'-tetrachloro[1,3'-bi-1H-pyrrole]-2,2'-diyl)bis[1-(2-hydroxyphenyl)-
- CBNumber:
- CB92677047
- Molecular Formula:
- C22H12Cl4N2O4
- Molecular Weight:
- 510.15
- MDL Number:
- MFCD28167731
- MOL File:
- 1227962-62-0.mol
Marinopyrrole A price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | T291055 | 1,1''-(4,4'',5,5''-Tetrachloro[1,3''-bi-1H-pyrrole]-2,2''-diyl)bis[1-(2-hydroxyphenyl)methanone] | 1227962-62-0 | 50mg | $760 | 2021-12-16 | Buy |
| ApexBio Technology | B1080 | MarinopyrroleA | 1227962-62-0 | 50mg | $929 | 2021-12-16 | Buy |
| ApexBio Technology | B1080 | MarinopyrroleA | 1227962-62-0 | 2mg | $95 | 2021-12-16 | Buy |
| ApexBio Technology | B1080 | MarinopyrroleA | 1227962-62-0 | 5mg | $150 | 2021-12-16 | Buy |
| ApexBio Technology | B1080 | MarinopyrroleA | 1227962-62-0 | 10mg | $268 | 2021-12-16 | Buy |
Marinopyrrole A Chemical Properties,Uses,Production
Uses
1,1''-(4,4'',5,5''-Tetrachloro[1,3''-bi-1H-pyrrole]-2,2''-diyl)bis[1-(2-hydroxyphenyl)methanone] is a marine anticancer compound. Also, it possesses anti-bacterial properties against methicillin-resistant Staphylococcus aureus.
Definition
ChEBI: (-)-marinopyrrole A is a member of the class of pyrroles that is 1'H-1,3'-bipyrrole substituted by four chloro groups at positions 4, 4', 5 and 5' and two 2-hydroxybenzoyl moieties at positions 2 and 2'. It is isolated from Streptomyces sp.CNQ-418 and exhibits cytotoxic and antibacterial activities. It has a role as an antimicrobial agent, an antibacterial agent, an antineoplastic agent, a marine metabolite and a bacterial metabolite. It is a member of pyrroles, an organochlorine compound, a member of phenols and an aromatic ketone.
Biological Activity
marinopyrrole a is a selective inhibitor of mcl-1 with ic50 value of 10.1μm [1].marinopyrrole a is a natural product froma species of marine-derived streptomycetes and is reported to be an antagonist of mcl-1. mcl-1 is a member of the anti-apoptotic bcl-2 family, which is a well-validated drug target for cancer treatment. nmr titration experiments show that marinopyrrole a can directly interact with mcl-1. it can prevent bim-bh3 peptides from binding to mcl-1 but not bcl-xl. the cell based assay shows a high selectivity of marinopyrrole a. treatment with marinopyrrole a inhibit the viability of k562 cells transfected with mcl-1 gene with ec50 value of 1.6μm. the selectivity is more than 40-fold greater over the cells transfected with bcl-xl gene. moreover, marinopyrrole a can decreases mcl-1 expression by increasing the cleavage of caspase-3 and parp. marinopyrrole a is also reported to completely restore the sensitivity of multidrug resistant leukemia cells to abt-737 [1].
IC 50
Mcl-1: 10.1 μM (IC50)
References
[1] doi k, li r, sung ss, et al. discovery of marinopyrrole a (maritoclax) as a selective mcl-1 antagonist that overcomes abt-737 resistance by binding to and targeting mcl-1 for proteasomal degradation. j biol chem. 2012 mar, 287(13): 10224-35.
Marinopyrrole A Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30231 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | sales@dogechemical.com | China | 4128 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38630 | 58 | |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8615965530500 | nickzhang@hangyubiotech.com | China | 10983 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 |
View Lastest Price from Marinopyrrole A manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | Maritoclax
1227962-62-0
|
US $38.00-89.00 / mg | 99.87% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-11-19 | Maritoclax
1227962-62-0
|
US $38.00-89.00 / mg | 99.87% | 10g | TargetMol Chemicals Inc. |
-
- Maritoclax
1227962-62-0
- US $38.00-89.00 / mg
- 99.87%
- TargetMol Chemicals Inc.
-
- Maritoclax
1227962-62-0
- US $38.00-89.00 / mg
- 99.87%
- TargetMol Chemicals Inc.