4-Hydroxybenzamide
- CAS No.
- 619-57-8
- Chemical Name:
- 4-Hydroxybenzamide
- Synonyms
- 4-HYDROXYBENZAMIDE;P-HYDROXYBENZAMIDE;Benzamide,p-hydroxy-;Benzamide,4-hydroxy-;4-Hydroxybenzamide>4-HYDROXYBENZAMIDE 98%;4-HYDROXYBENZAMIDE, 97+%;4-Hydroxybenzamide, 98+%;4-Hydroxy-benzoesaeure-amid;Benzamide, 4-hydroxy- (9CI)
- CBNumber:
- CB9271791
- Molecular Formula:
- C7H7NO2
- Molecular Weight:
- 137.14
- MDL Number:
- MFCD00007997
- MOL File:
- 619-57-8.mol
- MSDS File:
- SDS
| Melting point | 161-162 °C (lit.) |
|---|---|
| Boiling point | 345.3±25.0 °C(Predicted) |
| Density | 1.286±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| form | powder to crystal |
| pka | 8.60±0.13(Predicted) |
| color | White to Light yellow to Dark green |
| BRN | 1906921 |
| InChI | InChI=1S/C7H7NO2/c8-7(10)5-1-3-6(9)4-2-5/h1-4,9H,(H2,8,10) |
| InChIKey | QXSAKPUBHTZHKW-UHFFFAOYSA-N |
| SMILES | C(N)(=O)C1=CC=C(O)C=C1 |
| CAS DataBase Reference | 619-57-8(CAS DataBase Reference) |
| FDA UNII | 9OU5YD093J |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-37/39-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29242990 | |||||||||
| NFPA 704 |
|
4-Hydroxybenzamide price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 270253 | 4-Hydroxybenzamide 98% | 619-57-8 | 5g | $16.04 | 2024-03-01 | Buy |
| Sigma-Aldrich | 270253 | 4-Hydroxybenzamide 98% | 619-57-8 | 25g | $105.6 | 2024-03-01 | Buy |
| TCI Chemical | H0200 | 4-Hydroxybenzamide >98.0%(N) | 619-57-8 | 5g | $34 | 2024-03-01 | Buy |
| TCI Chemical | H0200 | 4-Hydroxybenzamide >98.0%(N) | 619-57-8 | 25g | $108 | 2024-03-01 | Buy |
| Alfa Aesar | B24222 | 4-Hydroxybenzamide, 98+% | 619-57-8 | 5g | $31.65 | 2024-03-01 | Buy |
4-Hydroxybenzamide Chemical Properties,Uses,Production
Chemical Properties
White to off-white crystalline powder
Uses
4-Hydroxybenzamide was used in the synthesis of balanol, a potent protein kinase C (PKC) inhibitor.
Uses
4-Hydroxybenzamide is a secondary metabolite from marine sponge Phakellia fusca.
Definition
4-Hydroxybenzamide (4HBM) is an important biological active compound that has the presence of various biological activities such as antimycobacterial, antifungal, antimicrobial, herbicidal, and antioxidant. The benzamide derivatives are also used in medical, pharmaceutical, and therapeutic applications because of their anti-inflammatory, antibacterial, and antifungal activities. The amine and carboxylic acids are important functional groups of present molecules. These are mainly utilized in the field of chemical industry. The cocrystallization of itraconazole (a very slightly soluble triazole antifungal drug) with 4-hydroxybenzamide (4OHBZA) can potentially increase the drug solubility at pH1.2 and 37 °C by 64 times[1-2].
References
[1] Ramesh P, et al. Theoretical and experimental spectroscopic studies of monomeric and dimeric structures of 4-hydroxybenzamide International Journal of Pharmaceutics. Journal of Molecular Structure, 2020; 1206: 127742.
[2] Vasilev N, et al. Novel cocrystals of itraconazole: Insights from phase diagrams, formation thermodynamics and solubility. International Journal of Pharmaceutics, 2021; 599: 120441.
Synthesis Reference(s)
Tetrahedron Letters, 19, p. 5183, 1978 DOI: 10.1016/S0040-4039(01)85844-5
General Description
The standard molar enthalpy of formation of 4-hydroxybenzamide was studied by micro- or macrocombustion calorimetry.
Source
4-Hydroxybenzamide is a natural product found in Oxytropis falcata, Houttuynia cordata, and Streptomyces tendae with data available.
4-Hydroxybenzamide Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Huida Pharmaceutical Technology (Shanghai) Co., Ltd. | +8613601750004 | lizhi@pharoschem.com | China | 439 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18750 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | sales@sdzschem.com | China | 2930 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29810 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | China | 52849 | 58 |
View Lastest Price from 4-Hydroxybenzamide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-10-28 | 4-Hydroxybenzamide
619-57-8
|
US $0.00 / mg | 10g | TargetMol Chemicals Inc. | |||
 |
2023-12-04 | 4-Hydroxybenzamide
619-57-8
|
US $0.00-0.00 / kg | 0.1kg | 98% | 100kg | Huida Pharmaceutical Technology (Shanghai) Co., Ltd. | |
 |
2023-12-04 | 4-Hydroxybenzamide
619-57-8
|
US $0.00-0.00 / kg | 0.1kg | 98% | 100kg | Huida Pharmaceutical Technology (Shanghai) Co., Ltd. |
-
- 4-Hydroxybenzamide
619-57-8
- US $0.00 / mg
- TargetMol Chemicals Inc.
-
- 4-Hydroxybenzamide
619-57-8
- US $0.00-0.00 / kg
- 98%
- Huida Pharmaceutical Technology (Shanghai) Co., Ltd.
-
- 4-Hydroxybenzamide
619-57-8
- US $0.00-0.00 / kg
- 98%
- Huida Pharmaceutical Technology (Shanghai) Co., Ltd.
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