2-(2-METHOXYPHENYL)-6-METHYL-4H-1-BENZOPYRAN-4-ONE
- CAS No.
- 89112-85-6
- Chemical Name:
- 2-(2-METHOXYPHENYL)-6-METHYL-4H-1-BENZOPYRAN-4-ONE
- Synonyms
- 2'MeO6MF;2''MeO6MF, 10 mM in DMSO;6-Methyl-2’-methoxyflavone;2-(2-Methoxyphenyl)-6-methyl-4H-chromen-4-one;2-(2-METHOXYPHENYL)-6-METHYL-4H-1-BENZOPYRAN-4-ONE;4H-1-Benzopyran-4-one, 2-(2-methoxyphenyl)-6-methyl-;Gamma-aminobutyric acid Receptor,2'MeO-6MF,α2β2/3γ2L,γ-Aminobutyric acid Receptor,inhibit,GABAA,inflammatory,2'MeO6MF,GABA Receptor,α2β1γ2L,Inhibitor,sedative,neuroprotection,anxiolytic,stroke,α2β2/3
- CBNumber:
- CB92748271
- Molecular Formula:
- C17H14O3
- Molecular Weight:
- 266.29
- MDL Number:
- MFCD03691655
- MOL File:
- 89112-85-6.mol
2-(2-METHOXYPHENYL)-6-METHYL-4H-1-BENZOPYRAN-4-ONE Chemical Properties,Uses,Production
Uses
2'MeO6MF is a brain-penetrant positive allosteric modulator at α2β1γ2L and all α1-containing GABAA receptors. 2'MeO6MF also can directly activate α2β2/3 and α2β2/3γ2L GABAA receptors. 2'MeO6MF has anxiolytic and psychomotor stabilizing properties. 2'MeO6MF offers neuroprotection and improved functional recovery and dampens the stroke-induced inflammatory response[1][2].
in vivo
2'MeO6MF (1-100 mg/kg; i.p.) displays anxiolytic-like effects in the elevated plus maze and light/dark tests. 2'MeO6MF induces sedative effects at higher doses in the holeboard, actimeter and barbiturate-induced sleep time tests[1].
2'MeO6MF (30 mg/kg; i.p.) increases tonic currents in layer 2/3 pyramidal neurons of mice after stroke[2].
2'MeO6MF (0.1-30 mg/kg; i.p.) is neuroprotective and enhances functional recovery after focal cerebral ischaemia in mice[2].
| Animal Model: | Male Balb-c mice (8-10 weeks, 25-35 g)[1] |
| Dosage: | 1, 10, 30, 100 mg/kg |
| Administration: | I.p. |
| Result: | No overt acute toxicity was observed. Exerted anxiolytic effects at low doses and sedative effects at high doses without myorelaxant effects. |
References
[1] Karim N, et, al. 2'-Methoxy-6-methylflavone: a novel anxiolytic and sedative with subtype selective activating and modulating actions at GABA(A) receptors. Br J Pharmacol. 2012 Feb;165(4):880-96. DOI:10.1111/j.1476-5381.2011.01604.x
[2] Clarkson AN, et, al. The flavonoid, 2'-methoxy-6-methylflavone, affords neuroprotection following focal cerebral ischaemia. J Cereb Blood Flow Metab. 2019 Jul;39(7):1266-1282. DOI:10.1177/0271678X18755628
2-(2-METHOXYPHENYL)-6-METHYL-4H-1-BENZOPYRAN-4-ONE Preparation Products And Raw materials
Raw materials
Preparation Products
2-(2-METHOXYPHENYL)-6-METHYL-4H-1-BENZOPYRAN-4-ONE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38630 | 58 | |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 12952 | 65 |
| Shanghai Chaolan Chemical Technology Center | 021-QQ：65489617 15618227136 | Sales@ATKchemical.com | China | 9330 | 58 |
| DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9409 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29774 | 58 |
| JinOu Biomedical (Nanjing) Co., Ltd. | 13000000000 | jinoupharma@163.com | China | 11721 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 62072 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24642 | 58 |
| Suzhou Zhixin Biotechnology Co., Ltd. | 0512-65118909 15162312715 | sales@szzxbio.com | China | 2972 | 58 |
