2-PHENYLPROPIONIC ACID
- CAS No.
- 492-37-5
- Chemical Name:
- 2-PHENYLPROPIONIC ACID
- Synonyms
- HYDRATROPIC ACID;Benzeneacetic acid, .alpha.-methyl-;2-Phenylproplonic Acid;(±)-α-methylphenylaceticacid;(±)-2-Phenylpropionic acid, (±)-Hydratropic acid;dl-PPA;2-Phenylpropionic;RARECHEM AL BO 0089;TIMTEC-BB SBB007855;DL-HYDRATROPIC ACID
- CBNumber:
- CB9293539
- Molecular Formula:
- C9H10O2
- Molecular Weight:
- 150.18
- MDL Number:
- MFCD00002650
- MOL File:
- 492-37-5.mol
- MSDS File:
- SDS
Melting point | 5 °C |
---|---|
Boiling point | 260-262 °C (lit.) |
Density | 1.1 g/mL at 25 °C (lit.) |
refractive index |
n |
Flash point | >230 °F |
storage temp. | Sealed in dry,Room Temperature |
solubility | 9.9g/l |
form | Liquid |
pka | 4.34±0.10(Predicted) |
color | Clear pale yellow to yellow |
PH | 3 (5g/l, H2O, 20℃) |
Water Solubility | 10 g/L (20 ºC) |
BRN | 1863558 |
LogP | 1.699 (est) |
CAS DataBase Reference | 492-37-5(CAS DataBase Reference) |
FDA UNII | CH15E393A2 |
NIST Chemistry Reference | Benzeneacetic acid, «alpha»-methyl-(492-37-5) |
EPA Substance Registry System | Benzeneacetic acid, .alpha.-methyl- (492-37-5) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS05 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Danger | |||||||||
Hazard statements | H314 | |||||||||
Precautionary statements | P280-P303+P361+P353-P305+P351+P338+P310 | |||||||||
Hazard Codes | Xi,C | |||||||||
Risk Statements | 36/37/38 | |||||||||
Safety Statements | 26-36-37/39 | |||||||||
WGK Germany | 3 | |||||||||
TSCA | Yes | |||||||||
HS Code | 29163900 | |||||||||
NFPA 704 |
|
2-PHENYLPROPIONIC ACID price More Price(36)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | P31701 | 2-Phenylpropionic acid 97% | 492-37-5 | 5g | $41.4 | 2024-03-01 | Buy |
Sigma-Aldrich | P31701 | 2-Phenylpropionic acid 97% | 492-37-5 | 10g | $80.3 | 2024-03-01 | Buy |
TCI Chemical | P0699 | DL-2-Phenylpropionic Acid >98.0%(GC)(T) | 492-37-5 | 5g | $16 | 2024-03-01 | Buy |
TCI Chemical | P0699 | DL-2-Phenylpropionic Acid >98.0%(GC)(T) | 492-37-5 | 25g | $44 | 2024-03-01 | Buy |
Alfa Aesar | L00709 | (±)-2-Phenylpropionic acid, 98% | 492-37-5 | 5g | $33.65 | 2024-03-01 | Buy |
2-PHENYLPROPIONIC ACID Chemical Properties,Uses,Production
Chemical Properties
clear pale yellow to yellow liquid
Uses
2-Phenylpropionic acid is used in the preparation of ibuprofen derivatives for their anti-inflammatory activity. Also used in nucleation inhibitors in Dutch resolution of diastereomers.
Definition
ChEBI: A 2-arylpropionic acid carrying a phenyl group at position 2. It is a metabolite of alpha-methylstyrene (AMS), a volatile hydrocarbon.
Synthesis Reference(s)
Journal of the American Chemical Society, 99, p. 182, 1977 DOI: 10.1021/ja00443a033
The Journal of Organic Chemistry, 51, p. 4354, 1986 DOI: 10.1021/jo00373a005
Tetrahedron Letters, 21, p. 581, 1980 DOI: 10.1016/S0040-4039(01)85562-3
Synthesis
2-Phenylpropionic acid is prepared:
1) from Benzyl cyanide by Metbylation with
Methyl iodide and Sodamide to produce alpha-Phenylpropionitrile, from which the
acid is produced by acid hydrolysis.
2) from Acetophenone cyanhydrin with Hydriodic
acid.
Purification Methods
Fractionally distil the acid, or recrystallise it from pet ether (b 40-60o) with strong cooling (see references below). [Beilstein 9 II 348.]
2-PHENYLPROPIONIC ACID Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shaanxi Dideu Medichem Co. Ltd | 18192627656 | 1012@dideu.com | China | 2995 | 58 |
Zhengzhou Anbu Chem Co.,Ltd | +86-0371-88006763; +8615988602810 | sales@anbuchem.com | China | 3000 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20294 | 58 |
airuikechemical co., ltd. | +undefined86-15315557071 | sales06@airuikechemical.com | China | 983 | 58 |
Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 885 | 50 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 16914 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21668 | 55 |
Jiangsu Qingquan Chemical Co., Ltd. | +86-571-86589381,86589382,86589383 | sales1@qqpharm.com | CHINA | 154 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
View Lastest Price from 2-PHENYLPROPIONIC ACID manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
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2024-08-15 | 2-PHENYLPROPIONIC ACID
492-37-5
|
US $0.00 / KG | 1KG | 98% | 1000KGS | Zhengzhou Anbu Chem Co.,Ltd | |
![]() |
2024-08-15 | 2-PHENYLPROPIONIC ACID
492-37-5
|
US $0.00 / KG | 0.10000000149011612KG | 98% | 1000KGS | Zhengzhou Anbu Chem Co.,Ltd | |
![]() |
2024-07-16 | 2-PHENYLPROPIONIC ACID
492-37-5
|
US $1.00-100.00 / KG | 1KG | 95% | 30000KG | Shaanxi Dideu Medichem Co. Ltd |
-
- 2-PHENYLPROPIONIC ACID
492-37-5
- US $0.00 / KG
- 98%
- Zhengzhou Anbu Chem Co.,Ltd
-
- 2-PHENYLPROPIONIC ACID
492-37-5
- US $0.00 / KG
- 98%
- Zhengzhou Anbu Chem Co.,Ltd
-
- 2-PHENYLPROPIONIC ACID
492-37-5
- US $1.00-100.00 / KG
- 95%
- Shaanxi Dideu Medichem Co. Ltd