ChemicalBook >> CAS DataBase List >>2-PHENYLPROPIONIC ACID
2-PHENYLPROPIONIC ACID
- CAS No.
- 492-37-5
- Chemical Name:
- 2-PHENYLPROPIONIC ACID
- Synonyms
- HYDRATROPIC ACID;Benzeneacetic acid, .alpha.-methyl-;2-Phenylproplonic Acid;(±)-α-methylphenylaceticacid;(±)-2-Phenylpropionic acid, (±)-Hydratropic acid;dl-PPA;2-Phenylpropionic;RARECHEM AL BO 0089;TIMTEC-BB SBB007855;DL-HYDRATROPIC ACID
- CBNumber:
- CB9293539
- Molecular Formula:
- C9H10O2
- Molecular Weight:
- 150.18
- MDL Number:
- MFCD00002650
- MOL File:
- 492-37-5.mol
- MSDS File:
- SDS
Last updated:2024-11-18 17:01:59
| Melting point | 5 °C |
|---|---|
| Boiling point | 260-262 °C (lit.) |
| Density | 1.1 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | 9.9g/l |
| form | Liquid |
| pka | 4.34±0.10(Predicted) |
| color | Clear pale yellow to yellow |
| PH | 3 (5g/l, H2O, 20℃) |
| Water Solubility | 10 g/L (20 ºC) |
| BRN | 1863558 |
| LogP | 1.699 (est) |
| CAS DataBase Reference | 492-37-5(CAS DataBase Reference) |
| FDA UNII | CH15E393A2 |
| NIST Chemistry Reference | Benzeneacetic acid, «alpha»-methyl-(492-37-5) |
| EPA Substance Registry System | Benzeneacetic acid, .alpha.-methyl- (492-37-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314 | |||||||||
| Precautionary statements | P280-P303+P361+P353-P305+P351+P338+P310 | |||||||||
| Hazard Codes | Xi,C | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29163900 | |||||||||
| NFPA 704 |
|
2-PHENYLPROPIONIC ACID price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P31701 | 2-Phenylpropionic acid 97% | 492-37-5 | 5g | $41.4 | 2024-03-01 | Buy |
| Sigma-Aldrich | P31701 | 2-Phenylpropionic acid 97% | 492-37-5 | 10g | $80.3 | 2024-03-01 | Buy |
| TCI Chemical | P0699 | DL-2-Phenylpropionic Acid >98.0%(GC)(T) | 492-37-5 | 5g | $16 | 2024-03-01 | Buy |
| TCI Chemical | P0699 | DL-2-Phenylpropionic Acid >98.0%(GC)(T) | 492-37-5 | 25g | $44 | 2024-03-01 | Buy |
| Alfa Aesar | L00709 | (±)-2-Phenylpropionic acid, 98% | 492-37-5 | 5g | $33.65 | 2024-03-01 | Buy |
2-PHENYLPROPIONIC ACID Chemical Properties,Uses,Production
Chemical Properties
clear pale yellow to yellow liquid
Uses
2-Phenylpropionic acid is used in the preparation of ibuprofen derivatives for their anti-inflammatory activity. Also used in nucleation inhibitors in Dutch resolution of diastereomers.
Definition
ChEBI: A 2-arylpropionic acid carrying a phenyl group at position 2. It is a metabolite of alpha-methylstyrene (AMS), a volatile hydrocarbon.
Synthesis Reference(s)
Journal of the American Chemical Society, 99, p. 182, 1977 DOI: 10.1021/ja00443a033
The Journal of Organic Chemistry, 51, p. 4354, 1986 DOI: 10.1021/jo00373a005
Tetrahedron Letters, 21, p. 581, 1980 DOI: 10.1016/S0040-4039(01)85562-3
Synthesis
2-Phenylpropionic acid is prepared:
1) from Benzyl cyanide by Metbylation with
Methyl iodide and Sodamide to produce alpha-Phenylpropionitrile, from which the
acid is produced by acid hydrolysis.
2) from Acetophenone cyanhydrin with Hydriodic
acid.
Purification Methods
Fractionally distil the acid, or recrystallise it from pet ether (b 40-60o) with strong cooling (see references below). [Beilstein 9 II 348.]
2-PHENYLPROPIONIC ACID Preparation Products And Raw materials
Global( 404)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Weibang Biotechnology Co., Ltd | +8615531157085 | abby@weibangbio.com | China | 8810 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | 18192627656 | 1012@dideu.com | China | 3002 | 58 |
| Zhengzhou Anbu Chem Co.,Ltd | +86-0371-88006763; +8615988602810 | sales@anbuchem.com | China | 2998 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20285 | 58 |
| airuikechemical co., ltd. | +undefined86-15315557071 | sales02@sdzhonghuimaterial.com | China | 983 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 +86-16264648883 | niki@zlchemi.com | China | 1226 | 58 |
| Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 880 | 50 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18774 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
View Lastest Price from 2-PHENYLPROPIONIC ACID manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-28 | 2-PHENYLPROPIONIC ACID
492-37-5
|
US $10.00 / kg | 1kg | 99% | 20 ton | Hebei Zhuanglai Chemical Trading Co Ltd | |
 |
2024-11-14 | 2-PHENYLPROPIONIC ACID
492-37-5
|
US $1.00 / kg | 1kg | 99% | 10 mt | Hebei Weibang Biotechnology Co., Ltd | |
 |
2024-10-15 | DL-2-Phenylpropionic acid
492-37-5
|
US $0.00-0.00 / g | 1g | 99.99% | 20 tons | airuikechemical co., ltd. |
-
- 2-PHENYLPROPIONIC ACID
492-37-5
- US $10.00 / kg
- 99%
- Hebei Zhuanglai Chemical Trading Co Ltd
-
- 2-PHENYLPROPIONIC ACID
492-37-5
- US $1.00 / kg
- 99%
- Hebei Weibang Biotechnology Co., Ltd
-
- DL-2-Phenylpropionic acid
492-37-5
- US $0.00-0.00 / g
- 99.99%
- airuikechemical co., ltd.
492-37-5(2-PHENYLPROPIONIC ACID)Related Search:
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RARECHEM AL BO 0089
(+/-)-2-PHENYLPROPIONIC ACID
2-PHENYLPROPIONIC ACID
α-methylbenzeneaceticacid
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TIMTEC-BB SBB007855
a-Methylphenylacetic acid
ALPHA-METHYLPHENYLACETIC ACID
HYDRATROPIC ACID 95% (GC)
(+/-)-2-Phenylpropionicacid,98%
2-Phenylpropionic
(+/-)-HYDRATROPIC ACID
DL-HYDRATROPIC ACID
DL-2-PHENYLPROPIONIC ACID
DL-2-Phenylpropionic acid, 98% 10GR
2-Phenylpropionic Acid, 97+%
(RS)-2-phenylpropionicacid
alpha-Methylbenzeneacetic acid
alpha-methyl-benzeneaceticaci
alpha-Phenylpropionic acid
benzeneaceticacid,α-methyl-
dl-alpha-Phenylpropionic acid
Propanoic acid, 2-phenyl
(2S)-2-phenylpropanoate
DL-2-PhenylpropionicAcid>
Benzeneacetic acid, .alpha.-methyl-
(±)-2-Phenylpropionic acid, (±)-Hydratropic acid
HYDRATROPIC ACID
(±)-α-methylphenylaceticacid
2-Phenylproplonic Acid
2-pronyl propionic acid
Benzeneacetic acid, α-methyl-
492-37-5
CH3CHC6H5COOH
C6H5CHCH3COOH
Carbonyl Compounds
C9
Carboxylic Acids
Building Blocks
Organic Building Blocks
CARBOXYLIC ACID
Carboxylic Acids
Aliphatics
Carboxylic Acids
Organic acids
Pharmaceutical Intermediates