ChemicalBook >> CAS DataBase List >>Lefamulin
Lefamulin
- CAS No.
- 1061337-51-6
- Chemical Name:
- Lefamulin
- Synonyms
- 2-[[(1R,2R,4R)-4-Amino-2-hydroxycyclohexyl]thio]acetic acid (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester;BC 3781;Lefamulin;Lefamulin(BC-3781);Lefamulin, 10 mM in DMSO;(3aR,4R,5R,7S,8S,9R,9aS,12R)-8-Hydroxy-4,7,9,12-tetramethyl-3-oxo-7-vinyldecahydro-4,9a-propanocyclopenta[8]annulen-5-yl 2-(((1R,2R,4R)-4-amino-2-hydroxycyclohexyl)thio)acetate;Acetic acid, 2-[[(1R,2R,4R)-4-amino-2-hydroxycyclohexyl]thio]-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester
- CBNumber:
- CB93039318
- Molecular Formula:
- C28H45NO5S
- Molecular Weight:
- 507.73
- MDL Number:
- MFCD28963989
- MOL File:
- 1061337-51-6.mol
- MSDS File:
- SDS
Last updated:2025-01-27 09:38:02
| Boiling point | 618.6±55.0 °C(Predicted) |
|---|---|
| Density | 1.19±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMF: 16 mg/mL; DMSO: 12 mg/mL; Ethanol: 3 mg/mL; PBS (pH 7.2): 0.25 mg/mL |
| form | A solid |
| pka | 14.45±0.60(Predicted) |
| color | White to off-white |
| InChIKey | KPVIXBKIJXZQJX-FCEONZPQSA-N |
| SMILES | C(O[C@@H]1C[C@](C=C)(C)[C@@H](O)[C@H](C)[C@@]23CC[C@@H](C)[C@]1(C)[C@]2([H])C(=O)CC3)(=O)CS[C@@H]1CC[C@@H](N)C[C@H]1O |
| FDA UNII | 21904A5386 |
| ATC code | J01XX12 |
| UNSPSC Code | 51101500 |
Lefamulin price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| DC Chemicals | 007448 | Lefamulin(BC-3781) | 1061337-51-6 | 004 | $450 | 2021-12-16 | Buy |
| DC Chemicals | DC8172 | Lefamulin(BC-3781) >98% | 1061337-51-6 | 100mg | $1000 | 2021-12-16 | Buy |
| DC Chemicals | DC8172 | Lefamulin(BC-3781) >98% | 1061337-51-6 | 250mg | $1700 | 2021-12-16 | Buy |
Lefamulin Chemical Properties,Uses,Production
Uses
Lefamulin is an antibiotic medication used in the treatment of adults with community-acquired bacterial pneumonia.
Biological Activity
Lefamulin inhibits bacterial protein synthesis by binding to the 50S subunit of the bacterial ribosome. Specifically, it binds to the peptidyl transferase center of the ribosome and inhibits the transfer of amino acids to growing polypeptide chains, which leads to the inhibition of bacterial protein synthesis and bacterial death. Lefamulin is active against a wide range of Gram-positive bacteria, including Streptococcus pneumoniae, Staphylococcus aureus, and methicillin-resistant S. aureus (MRSA), as well as some atypical bacteria such as Legionella species. It has also been shown to have activity against some Gram-negative bacteria, including Haemophilus influenzae and Moraxella catarrhalis.
Lefamulin Preparation Products And Raw materials
Raw materials
Cyclohexene, 4-isocyanato-, (4R)-
Acetic acid, 2-[[(1R,2R,4R)-2-hydroxy-4-[(2,2,2-trifluoroacetyl)amino]cyclohexyl]thio]-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester
1350636-88-2
tert-butyl N-[(1R)-cyclohex-3-en-1-yl]carbamate
tert-butyl N-[(1R,3R,4R)-3-hydroxy-4-sulfanylcyclohexyl]carbamate
1of2
Preparation Products
Lefamulin Suppliers
Global( 63)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| CR Corporation Limited | +8613062833949 | fred.wen@crcorporation.cn | China | 8647 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
| Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | sales@dogechemical.com | China | 4128 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38631 | 58 | |
| Zhengzhou Anbu Chem Co.,Ltd | +86-0371-88006763; +8615988602810 | sales@anbuchem.com | China | 2998 | 58 |
| Shanghai Qianyi New Material Co., Ltd. | +8618083322317 | 3391883138@qq.com | China | 878 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Shanghai Likang New Materials Co., Limited | +86-16631818819 +86-17736933208 | 3684455296@qq.com | China | 9300 | 58 |
| XIAMEN AMITY INDUSTRY AND TRADE CO., LTD. | +8618950047208 | ellena@amitychem.com | China | 43416 | 58 |
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- Jan 5，2024
View Lastest Price from Lefamulin manufacturers
Lefamulin
BC 3781
Lefamulin(BC-3781)
Acetic acid, 2-[[(1R,2R,4R)-4-amino-2-hydroxycyclohexyl]thio]-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester
2-[[(1R,2R,4R)-4-Amino-2-hydroxycyclohexyl]thio]acetic acid (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester
(3aR,4R,5R,7S,8S,9R,9aS,12R)-8-Hydroxy-4,7,9,12-tetramethyl-3-oxo-7-vinyldecahydro-4,9a-propanocyclopenta[8]annulen-5-yl 2-(((1R,2R,4R)-4-amino-2-hydroxycyclohexyl)thio)acetate
Lefamulin, 10 mM in DMSO
1061337-51-6
C28H45NO5S
API