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Lefamulin

Lefamulin structure

CAS No.: 1061337-51-6

Chemical Name:: Lefamulin

Synonyms: 2-[[(1R,2R,4R)-4-Amino-2-hydroxycyclohexyl]thio]acetic acid (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester;BC 3781;Lefamulin;Lefamulin(BC-3781);(3aR,4R,5R,7S,8S,9R,9aS,12R)-8-Hydroxy-4,7,9,12-tetramethyl-3-oxo-7-vinyldecahydro-4,9a-propanocyclopenta[8]annulen-5-yl 2-(((1R,2R,4R)-4-amino-2-hydroxycyclohexyl)thio)acetate;Acetic acid, 2-[[(1R,2R,4R)-4-amino-2-hydroxycyclohexyl]thio]-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester

CBNumber:: CB93039318

Molecular Formula:: C28H45NO5S

Molecular Weight:: 507.73

MDL Number:: MFCD28963989

MOL File:: 1061337-51-6.mol

MSDS File:: SDS

Last updated:2024-11-19 20:33:22

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Lefamulin Properties

Boiling point	618.6±55.0 °C(Predicted)
Density	1.19±0.1 g/cm3(Predicted)
solubility	DMF: 16 mg/mL; DMSO: 12 mg/mL; Ethanol: 3 mg/mL; PBS (pH 7.2): 0.25 mg/mL
form	A solid
pka	14.45±0.60(Predicted)
color	White to off-white
InChIKey	KPVIXBKIJXZQJX-FCEONZPQSA-N
SMILES	C(O[C@@H]1C[C@](C=C)(C)[C@@H](O)[C@H](C)[C@@]23CC[C@@H](C)[C@]1(C)[C@]2([H])C(=O)CC3)(=O)CS[C@@H]1CC[C@@H](N)C[C@H]1O
FDA UNII	21904A5386
ATC code	J01XX12

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS09
Signal word	Warning
Hazard statements	H411

Lefamulin price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
DC Chemicals	007448	Lefamulin(BC-3781)	1061337-51-6	004	$450	2021-12-16	Buy
DC Chemicals	DC8172	Lefamulin(BC-3781) >98%	1061337-51-6	100mg	$1000	2021-12-16	Buy
DC Chemicals	DC8172	Lefamulin(BC-3781) >98%	1061337-51-6	250mg	$1700	2021-12-16	Buy

Product number	Packaging	Price	Buy
007448	004	$450	Buy
DC8172	100mg	$1000	Buy
DC8172	250mg	$1700	Buy

Lefamulin Chemical Properties,Uses,Production

Uses

Lefamulin is an antibiotic medication used in the treatment of adults with community-acquired bacterial pneumonia.

Lefamulin synthesis

Synthesis of Lefamulin from (R)-(+)-3-CYCLOHEXENECARBOXYLIC ACID

Lefamulin Preparation Products And Raw materials

Raw materials

Cyclohexene, 4-isocyanato-, (4R)- Acetic acid, 2-[[(1R,2R,4R)-2-hydroxy-4-[(2,2,2-trifluoroacetyl)amino]cyclohexyl]thio]-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester 1350636-88-2 tert-butyl N-[(1R)-cyclohex-3-en-1-yl]carbamate tert-butyl N-[(1R,3R,4R)-3-hydroxy-4-sulfanylcyclohexyl]carbamate

TiaMulin Related CoMpound A {(1R,2R,4R)-4-[(tert-butoxycarbonyl)-amino]-2-hydroxy-cyclohexyl} benzene-carbothioate (R)-(+)-3-CYCLOHEXENECARBOXYLIC ACID 3-Cyclohexenecarboxylic acid

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Preparation Products

Lefamulin acetate

Lefamulin Suppliers

Global( 58)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
CR Corporation Limited	+8613062833949	fred.wen@crcorporation.cn	China	8647	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418684 +8618949823763	sales@tnjchem.com	China	25356	58
Nanjing Doge Biomedical Technology Co., Ltd	+86-25-58227606 +86-15305155328	sales@dogechemical.com	China	4128	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38631	58
Zhengzhou Anbu Chem Co.,Ltd	+86-0371-88006763; +8615988602810	sales@anbuchem.com	China	2998	58
Shanghai Qianyi New Material Co., Ltd.	+8618083322317	3391883138@qq.com	China	878	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8467	58
Shanghai Likang New Materials Co., Limited	+86-16631818819 +86-17736933208	3684455296@qq.com	China	9300	58
BEIJING INNO-TECH PHARMIC TECHNOLOGY CO.,LTD	15011485209		China	145	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
CR Corporation Limited	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Nanjing Doge Biomedical Technology Co., Ltd	58
TargetMol Chemicals Inc.	58
Zhengzhou Anbu Chem Co.,Ltd	58
Shanghai Qianyi New Material Co., Ltd.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
Shanghai Likang New Materials Co., Limited	58
BEIJING INNO-TECH PHARMIC TECHNOLOGY CO.,LTD	58

A semisynthetic pleuromutilin antibiotic: Lefamulin
Lefamulin, a semisynthetic pleuromutilin antibiotic, has been approved by the FDA for IV and oral treatment of community-acqui....
Jan 5，2024

View Lastest Price from Lefamulin manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-19	Lefamulin 1061337-51-6	US $80.00-272.00 / mg		99.63%	10g	TargetMol Chemicals Inc.
	2024-08-15	Lefamulin 1061337-51-6	US $0.00 / KG	0.1KG	99%	1000KGS	Zhengzhou Anbu Chem Co.,Ltd

Lefamulin
1061337-51-6
US $80.00-272.00 / mg
99.63%
TargetMol Chemicals Inc.

Lefamulin
1061337-51-6
US $0.00 / KG
99%
Zhengzhou Anbu Chem Co.,Ltd

Lefamulin Spectrum

Lefamulin(1061337-51-6)¹HNMR

Lefamulin BC 3781 Lefamulin(BC-3781) Acetic acid, 2-[[(1R,2R,4R)-4-amino-2-hydroxycyclohexyl]thio]-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester 2-[[(1R,2R,4R)-4-Amino-2-hydroxycyclohexyl]thio]acetic acid (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester (3aR,4R,5R,7S,8S,9R,9aS,12R)-8-Hydroxy-4,7,9,12-tetramethyl-3-oxo-7-vinyldecahydro-4,9a-propanocyclopenta[8]annulen-5-yl 2-(((1R,2R,4R)-4-amino-2-hydroxycyclohexyl)thio)acetate 1061337-51-6 C28H45NO5S API