2-Bromo-4'-hydroxyacetophenone
- CAS No.
- 2491-38-5
- Chemical Name:
- 2-Bromo-4'-hydroxyacetophenone
- Synonyms
- 2-bromo-1-(4-hydroxyphenyl)ethan-1-one;BHAP;BUSAN90;BUSAN1130;Butrol 1130;PTP INHIBITOR I;SHP-1 Inhibitor II;4-HYDROXYPHENACYL BR;4-(Bromoacetyl)phenol;Cyclohexane Impurity 5
- CBNumber:
- CB9306895
- Molecular Formula:
- C8H7BrO2
- Molecular Weight:
- 215.04
- MDL Number:
- MFCD00072424
- MOL File:
- 2491-38-5.mol
Melting point | 123-126°C |
---|---|
Boiling point | 338.7±17.0 °C(Predicted) |
Density | 1.622±0.06 g/cm3(Predicted) |
storage temp. | Inert atmosphere,2-8°C |
solubility | Chloroform (Slightly), Methanol (Slightly) |
pka | 7.69±0.15(Predicted) |
form | White powder |
color | White to Light Beige |
Sensitive | Lachrymatory |
BRN | 1865388 |
Stability | Hygroscopic |
Indirect Additives used in Food Contact Substances | 2-BROMO-4'-HYDROXYACETOPHENONE |
FDA 21 CFR | 176.170; 176.300 |
CAS DataBase Reference | 2491-38-5(CAS DataBase Reference) |
FDA UNII | 6H0QU4I6BA |
EPA Substance Registry System | 2-Bromo-4-hydroxyacetophenone (2491-38-5) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302-H319 | |||||||||
Precautionary statements | P264-P270-P280-P301+P312-P305+P351+P338-P337+P313 | |||||||||
Hazard Codes | C,Xn | |||||||||
Risk Statements | 22-36 | |||||||||
Safety Statements | 26 | |||||||||
RIDADR | 1760 | |||||||||
WGK Germany | 1 | |||||||||
RTECS | AM5982000 | |||||||||
Hazard Note | Corrosive/Lachrymatory/Keep Cold | |||||||||
HazardClass | 8 | |||||||||
PackingGroup | III | |||||||||
HS Code | 2914500090 | |||||||||
NFPA 704 |
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2-Bromo-4'-hydroxyacetophenone price More Price(40)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | CDS013566 | 2-bromo-4′-hydroxyacetophenone AldrichCPR | 2491-38-5 | 1G | $81.6 | 2023-06-20 | Buy |
TCI Chemical | B4115 | 2-Bromo-4'-hydroxyacetophenone >98.0%(HPLC)(T) | 2491-38-5 | 5g | $48 | 2024-03-01 | Buy |
TCI Chemical | B4115 | 2-Bromo-4'-hydroxyacetophenone >98.0%(HPLC)(T) | 2491-38-5 | 25g | $151 | 2024-03-01 | Buy |
Cayman Chemical | 19766 | PTP Inhibitor I ≥98% | 2491-38-5 | 5g | $60 | 2023-06-20 | Buy |
Cayman Chemical | 19766 | PTP Inhibitor I ≥98% | 2491-38-5 | 10g | $112 | 2023-06-20 | Buy |
2-Bromo-4'-hydroxyacetophenone Chemical Properties,Uses,Production
Description
PTP Inhibitor I is a cell-permeable, protein tyrosine phosphatase (PTP) inhibitor that covalently blocks the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)) with a Ki value of 43 μM and PTP1B with a Ki value of 42 μM. SHP-1 and PTP1B both have known roles in regulating insulin signaling as well as myeloid and lymphoid cell differentiation, making inhibitors of these phosphatases of interest in diabetes, cancer, allergy, and inflammation research.
Chemical Properties
Pale Beige Solid
Uses
A covalent inhibitor of protein tyrosine phosphatases (PTPs)
Preparation
Also obtained by reaction of pyridinium hydrobromide perbromide with 4-hydroxyacetophenone in THF at r.t. for 3 h.
in vitro
in previous study, the corresponding values of ptp inhibitor i against ptp1b were determined to be ki of 42 μm, kinact of 0.57 min-1, and kinact/ki of 1.4*104 m-1 min-1, respectively. this study also showed that α-bromoacetophenone such as ptp inhibitor i could provide an effective, neutral py mimetic inhibitor of ptps. while perturbation of the electronic properties of the phenyl ring did not significantly improve its potency against ptps, attachment of a proper peptidyl moiety to the para position could improve both the potency and the selectivity substantially. in addition, since the covalent ptp inhibitor complex could be cleaved to regenerate the ptp activity photolytically, ptp inhibitor i might provide a novel class of photolytic switch for controlling cellular signaling processes [1].
References
[1] arabaci g, yi t, fu h, porter me, beebe kd, pei d. alpha-bromoacetophenone derivatives as neutral protein tyrosine phosphatase inhibitors: structure-activity relationship. bioorg med chem lett. 2002 nov 4;12(21):3047-50.
2-Bromo-4'-hydroxyacetophenone Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 16920 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21669 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29896 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
Changzhou Ditong Chemical Co.,Ltd | +86-0519-88299272 | info@edengenechem.com | China | 2169 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-29-81148696 +86-15536356810 | 1022@dideu.com | China | 2798 | 58 |
Tangshan Moneide Trading Co., Ltd. | +86-315-8309571 +8615633399667 | sales@moneidechem.com | China | 574 | 58 |
View Lastest Price from 2-Bromo-4'-hydroxyacetophenone manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
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2022-09-20 | 2-Bromo-4'-hydroxyacetophenone
2491-38-5
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | |
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2020-06-30 | 2-Bromo-4'-hydroxyacetophenone
2491-38-5
|
US $2230.00 / KG | 1KG | 98.0% | 1T | Shaanxi Dideu Medichem Co. Ltd | |
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2019-07-06 | 2-Bromo-4'-hydroxyacetophenone
2491-38-5
|
US $8.80 / KG | 1KG | 97%-99% | 100kg | Career Henan Chemical Co |
-
- 2-Bromo-4'-hydroxyacetophenone
2491-38-5
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 2-Bromo-4'-hydroxyacetophenone
2491-38-5
- US $2230.00 / KG
- 98.0%
- Shaanxi Dideu Medichem Co. Ltd
-
- 2-Bromo-4'-hydroxyacetophenone
2491-38-5
- US $8.80 / KG
- 97%-99%
- Career Henan Chemical Co
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