Semaglutide
- CAS No.
- 910463-68-2
- Chemical Name:
- Semaglutide
- Synonyms
- semaglutide;Semaglutide impurity;Sermaglutide USP/EP/BP;Sermaglutide CAS 910463 68 2;OG217SC;Ozempic;Somaroutin;semgalutide;Somaglutide;Somarlutide
- CBNumber:
- CB93069423
- Molecular Formula:
- C187H291N45O59
- Molecular Weight:
- 4113.57754
- MDL Number:
- MOL File:
- 910463-68-2.mol
| storage temp. | Store at -20°C |
|---|---|
| solubility | DMSO：3mg/mL (0.73 mM) |
| form | Solid |
| color | White to off-white |
| InChIKey | DLSWIYLPEUIQAV-CCUURXOWSA-N |
| FDA UNII | 53AXN4NNHX |
| ATC code | A10BJ06 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H361 |
| Precautionary statements | P201-P202-P281-P308+P313-P405-P501 |
Semaglutide price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth Carbosynth | FS171058 | Semaglutide | 910463-68-2 | 10mg | $37.5 | 2021-12-16 | Buy |
| Adipogen Life Sciences | AG-CP3-0040-M001 | Semaglutide ≥98%(HPLC) | 910463-68-2 | 1mg | $55 | 2021-12-16 | Buy |
| ChemScene | CS-0069903 | Semaglutide 99.84% | 910463-68-2 | 500ug | $160 | 2021-12-16 | Buy |
| Adipogen Life Sciences | AG-CP3-0040-M005 | Semaglutide ≥98%(HPLC) | 910463-68-2 | 5mg | $220 | 2021-12-16 | Buy |
| ChemScene | CS-0069903 | Semaglutide 99.84% | 910463-68-2 | 1mg | $260 | 2021-12-16 | Buy |
Semaglutide Chemical Properties,Uses,Production
Description
Semaglutide(910463-68-2) is an anti-diabetic medication that is sold under brand names such as Ozempic, Wegovy, and Rybelsus. It is used to treat type 2 diabetes and manage chronic weight. The drug functions similar to human glucagon-like peptide-1 (GLP-1) by increasing insulin secretion, which leads to improved sugar metabolism. It is distributed as a metered subcutaneous injection in a prefilled pen, or as an oral form. One of its advantages over other antidiabetic drugs is that it has a long duration of action, thus, only once-a-week injection is sufficient.
Uses
Semaglutide is used to manage type 2 diabetes along with lifestyle changes, such as dietary restrictions and increased physical activity. It also works by slowing the movement of food through the stomach and may decrease appetite and cause weight loss. There have been no published reports of hepatotoxicity attributed to semaglutide therapy.
Definition
ChEBI: Semaglutide is a polypeptide that contains a linear sequence of 31 amino acids joined together by peptide linkages. It is an agonist of glucagon-like peptide-1 receptors (GLP-1 AR) and used for the treatment of type 2 diabetes. It has a role as a hypoglycemic agent, a glucagon-like peptide-1 receptor agonist, an anti-obesity agent, a neuroprotective agent and an appetite depressant. It is a polypeptide and a lipopeptide.
Biological Activity
Semaglutide (Rybelsus, Ozempic, NN9535, OG217SC, NNC 0113-0217), a long-acting glucagon-like peptide 1 (GLP-1) analogue, is a GLP-1 receptor agonist with the potential for the treatment of type 2 diabetes mellitus (T2DM).
Mechanism of action
Semaglutide is a glucagon-like peptide-1 receptor agonist. It increases the production of insulin, a hormone that lowers the blood sugar level. It also appears to enhance growth of β cells in the pancreas, which are the sites of insulin production. It also inhibits glucagon, which is a hormone that increases blood sugar. It additionally reduces food intake by lowering appetite and slows down digestion in the stomach. In this way it reduces body fat.
Pharmacokinetics
Median tmax,semaglutide was 1.5 hours for both water volumes with a range of 0.5-3.0 hours for 50 mL and a range of 0.5-4.0 hours for 240 mL. AUC0-24h,semaglutide and Cmax,semaglutide were approximately 70% higher when dosed with 50 versus 240 mL water[2].
Side effects
Some common side effects of Semaglutide include: nausea, vomiting, diarrhea, abdominal pain, and constipation may occur.
Less common but serious side effects of Semaglutide include: kidney problems, diabetic retinopathy, allergic reactions, low blood sugar, and pancreatitis.
In people with heart problems, it can cause damage to the back of the eye (retinopathy). If you experience any of these serious side effects, contact your healthcare provider immediately.
www.mayoclinic.org
in vitro
Semaglutide is selected as the optimal once weekly candidate. Semaglutide has two amino acid substitutions compared to human GLP-1 (Aib8, Arg34) and is derivatized at lysine 26. The GLP-1R affinity of semaglutide (0.38 ± 0.06 nM) is three-fold decreased compared to liraglutide, whereas the albumin affinity is increased.
in vivo
The plasma half-life is 46.1 h in mini-pigs following i.v. administration, and semaglutide has an MRT of 63.6 h after s.c. dosing to mini-pigs.
Metabolism
Intact semaglutide was the primary component circulating in plasma for humans and both nonclinical species, accounting for 69–83% of the total amount of semaglutide-related material, and was metabolised prior to excretion. Recovery of excreted radioactivity was 75.1% in humans, 72.1% in rats and 58.2% in monkeys. Urine and faeces were shown to be important routes of excretion, with urine as the primary route in both humans and animals[1]. Semaglutide was metabolised through proteolytic cleavage of the peptide backbone and sequential beta-oxidation of the fatty acid sidechain, and metabolism was not confined to specific organs. Intact semaglutide in urine accounted for 3.1% of the administered dose in humans and less than 1% in rats; it was not detected in urine in monkeys.
Precautions
The FDA recommends Wegovy for weight loss if you meet one of the following criteria: Have a body mass index (BMI) of 27kg/m2 or greater and at least one weight-related condition, such as high blood pressure, Type 2 diabetes, or high cholesterol; Have a BMI of 30kg/m2 or greater.
Avoid semaglutide if you have: History of medullary thyroid cancer; History of gallbladder disease; History of pancreatitis; Multiple endocrine neoplasia syndrome type 2 (MEN2).
References
[1] A, Lene Jensen , et al. "Absorption, metabolism and excretion of the GLP-1 analogue semaglutide in humans and nonclinical species." European Journal of Pharmaceutical Sciences 104(2017):31-41.
[2] Tine A. B?kdal. “Relationship Between Oral Semaglutide Tablet Erosion and Pharmacokinetics: A Pharmacoscintigraphic Study.” Clinical Pharmacology in Drug Development 10 5 (2021): 453–462.
Semaglutide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Yuanao Technology CO Ltd | +86-15377628618 +86-15377628618 | info@yuanaotech.com | China | 6 | 58 |
| Shanghai Longyu Biotechnology Co., Ltd. | +8619521488211 | info@longyupharma.com | China | 2541 | 58 |
| Cellmano Biotech Limited | 0551-65326643 18156095617 | info@cellmano.com | China | 999 | 58 |
| Alpha Biopharmaceuticals Co., Ltd | +86-15542445688 | sales@alabiochem.com | China | 888 | 58 |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15352 | 58 |
| Senova Technology Co. Ltd. | +86-0755-86703119 +8618503098836 | info@senovatech.com | China | 351 | 58 |
| Sinoway Industrial co., ltd. | 0592-5800732; +8613806035118 | xie@china-sinoway.com | China | 988 | 58 |
| Wuhan Cell Pharmaceutical Co., Ltd | +86-13129979210 +86-13129979210 | sales@cellwh.com | China | 376 | 58 |
| Sigma Audley | +86-15937194204 +86-18126314766 | nova@sh-teruiop.com | China | 467 | 58 |
| Dorne Chemical Technology co. LTD | +86-86-13583358881 +8618560316533 | Ethan@dornechem.com | China | 3096 | 58 |
Related articles
- The application of Semaglutide
- Semaglutide is a glucagon‐like peptide‐1 receptor agonist (GLP‐1 RA) with a long elimination half‐life, allowing subcutaneous ....
- Jul 5，2022
- Sermaglutide- Medical uses, Adverse effects, Mechanism of action etc.
- Semaglutide is a glucagon-like peptide (GLP-1) analog. GLP-1 is a hormone produced in the small intestine that stimulates insu....
- Dec 13，2021
Related Qustion
- Q:Is oral semaglutide as effective as the injectable version for weight loss?
- A:Semaglutide is a glucagon-like peptide-1 receptor agonist (GLP-1 receptor agonist) that can help treat type 2 diabetes by incr....
- Apr 12，2024
View Lastest Price from Semaglutide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-12-01 | Semaglutide
910463-68-2
|
US $500.00-450.00 / gram | 1gram | 99% | 10kg | HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | |
 |
2024-12-01 | Semaglutide
910463-68-2
|
US $0.00-0.00 / MG | 100MG | 99% HPLC | 10000 | HangZhou RunYan Pharma Technology Co.,LTD. | |
 |
2024-11-30 | Semaglutide
910463-68-2
|
US $1.00 / g | 1g | 99% | 100kg | Dorne Chemical Technology co. LTD |
-
- Semaglutide
910463-68-2
- US $500.00-450.00 / gram
- 99%
- HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
-
- Semaglutide
910463-68-2
- US $0.00-0.00 / MG
- 99% HPLC
- HangZhou RunYan Pharma Technology Co.,LTD.
-
- Semaglutide
910463-68-2
- US $1.00 / g
- 99%
- Dorne Chemical Technology co. LTD