Ethyl 4-(4-cyanophenyl)butanoate
- CAS No.
- 131379-33-4
- Chemical Name:
- Ethyl 4-(4-cyanophenyl)butanoate
- Synonyms
- Ethyl 4-(4-cyanophenyl)butanoate;Benzenebutanoic acid, 4-cyano-, ethyl ester
- CBNumber:
- CB93070690
- Molecular Formula:
- C13H15NO2
- Molecular Weight:
- 217.26
- MDL Number:
- MFCD30741257
- MOL File:
- 131379-33-4.mol
- MSDS File:
- SDS
Ethyl 4-(4-cyanophenyl)butanoate Chemical Properties,Uses,Production
Uses
Ethyl 4-(4-cyanophenyl)butanoate can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and pharmaceutical and chemical production process.
Synthesis
Add Hans ester Et-HE (0.8mmol) to the reaction tube equipped with a magnetic stir bar, Ru(bpy)3Cl2?¤6H2O (0.004 mmol) and p-cresol (0.08 mmol). Cover the reaction tube and change the nitrogen three times, Use a micro syringe to inject 4-cyanostyrene (0.4mmol), Ethyl diazoacetate (0.8 mmol) and anhydrous dichloromethane (2.0 mL, 0.2M). Then the reaction tube was placed about 15 cm away from the 50W blue light source for illumination and stirring. React at 25??C for 12 hours until the diazonium consumption is complete (monitored by thin layer chromatography). After the solvent was removed by rotary evaporation under reduced pressure, a crude product was obtained. The crude product was purified by silica gel column chromatography to obtain the corresponding product (petroleum ether: ethyl acetate=25:1), the total yield: 86%.
Ethyl 4-(4-cyanophenyl)butanoate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25363 | 58 |
| Aromsyn Co., Ltd. | +86-0571-85585865 +8613336024896 | CB@aromsyn.com | China | 19185 | 58 |
| Hangzhou Milestone Pharmtech Co., Ltd. | 0571-82896630 18969958410 | sales_hz@milestonepharmtech.com | China | 4849 | 55 |
| Shaanxi Dideu Medichem Co. Ltd | 029-81124267 15229202216 | 1073@dideu.com | China | 10011 | 58 |
| Aikon International Limited | 18626450290 | yftan@aikonchem.com | China | 10718 | 58 |