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GSK 2033

GSK 2033 structure

CAS No.: 1221277-90-2

Chemical Name:: GSK 2033

Synonyms: SK2033;GSK 2033;LXR antagonist 2033;GSK2033 >=98% (HPLC);Liver X receptor,Inhibitor,GSK 2033,inhibit,LXR,GSK2033,GSK-2033;2,4,6-Trimethyl-N-[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl]-N-[[5-(trifluoromethyl)-2-furanyl]methyl]benzenesulfonamide;2,4,6-trimethyl-N-[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl]-N-[[5-(trifluoromethyl)-2-furanyl]methyl]-benzenesulfonamide;Benzenesulfonamide, 2,4,6-trimethyl-N-[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl]-N-[[5-(trifluoromethyl)-2-furanyl]methyl]-

CBNumber:: CB93146298

Molecular Formula:: C29H28F3NO5S2

Molecular Weight:: 591.66

MDL Number:: MFCD28396416

MOL File:: 1221277-90-2.mol

MSDS File:: SDS

Last updated:2024-11-19 20:33:22

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GSK 2033 Properties

storage temp.	2-8°C
solubility	DMF:5.0(Max Conc. mg/mL);8.45(Max Conc. mM) DMSO:17.46(Max Conc. mg/mL);29.51(Max Conc. mM)
form	powder
color	white to beige

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

GSK 2033 price More Price(16)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML1617	GSK2033 ≥98% (HPLC)	1221277-90-2	5MG	$159	2023-06-20	Buy
Sigma-Aldrich	SML1617	GSK2033 ≥98% (HPLC)	1221277-90-2	25MG	$639	2023-06-20	Buy
Cayman Chemical	25443	GSK2033 ≥98%	1221277-90-2	1mg	$32	2024-03-01	Buy
Cayman Chemical	25443	GSK2033 ≥98%	1221277-90-2	5mg	$139	2024-03-01	Buy
Cayman Chemical	25443	GSK2033 ≥98%	1221277-90-2	10mg	$230	2024-03-01	Buy

Product number	Packaging	Price	Buy
SML1617	5MG	$159	Buy
SML1617	25MG	$639	Buy
25443	1mg	$32	Buy
25443	5mg	$139	Buy
25443	10mg	$230	Buy

GSK 2033 Chemical Properties,Uses,Production

Uses

GSK 2033 is a potent LXR antagonist.

Biochem/physiol Actions

GSK2033 is an antagonist of the nuclear receptor liver-X-receptor (LXR) with pIC50 values of 7.0 for LXRα and 7.4 for LXRβ. Treatment of murine CD41 T cells with GSK2033 enhanced cellular proliferation and Th1/Th2/Th17 differentiation. In another study, the conjugated linoleic acid (CLA)-induced expression of efflux protein ATP-binding-cassette transporter A1 (ABCA1) was completely abolished by preincubation with GSK2033, showing that CLA mediated regulation of ABCA-1 expression is LXR dependent.

storage

Store at +4°C

GSK 2033 Preparation Products And Raw materials

Raw materials

Preparation Products

GSK 2033 Suppliers

Global( 52)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32957	60
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32165	58
Chemia Biotechnology（Shanghai） Co., Ltd	+8613816753574	info@chemia-pharm.com	CHINA	311	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3135	58
Jilin Chinese Academy of Sciences-yanshen Technology	+undefined18143011203	info@chemextension.com	China	42056	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57505	58
ShangHai Caerulum Pharma Discovery Co., Ltd.	18149758185 18149758185	sales-cpd@caerulumpharma.com	China	3466	58
Sichuan Wei Keqi Biological Technology Co., Ltd.	028-81700200 18116577057	3003855609@qq.com	China	7887	56
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51456	80

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
TargetMol Chemicals Inc.	58
Chemia Biotechnology（Shanghai） Co., Ltd	58
InvivoChem	58
Nantong HI-FUTURE Biology Co., Ltd.	58
Jilin Chinese Academy of Sciences-yanshen Technology	58
Aladdin Scientific	58
ShangHai Caerulum Pharma Discovery Co., Ltd.	58
Sichuan Wei Keqi Biological Technology Co., Ltd.	56
Sigma-Aldrich	80

View Lastest Price from GSK 2033 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-19	GSK2033 1221277-90-2	US $44.00-163.00 / mg		99.05%	10g	TargetMol Chemicals Inc.

GSK2033
1221277-90-2
US $44.00-163.00 / mg
99.05%
TargetMol Chemicals Inc.

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GSK 2033 LXR antagonist 2033 2,4,6-Trimethyl-N-[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl]-N-[[5-(trifluoromethyl)-2-furanyl]methyl]benzenesulfonamide Benzenesulfonamide, 2,4,6-trimethyl-N-[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl]-N-[[5-(trifluoromethyl)-2-furanyl]methyl]- GSK2033 >=98% (HPLC) Liver X receptor,Inhibitor,GSK 2033,inhibit,LXR,GSK2033,GSK-2033 2,4,6-trimethyl-N-[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl]-N-[[5-(trifluoromethyl)-2-furanyl]methyl]-benzenesulfonamide SK2033 1221277-90-2 C29H28F3NO5S2