PPACKII (trifluoroacetate salt)
- CAS No.
- 649748-23-2
- Chemical Name:
- PPACKII (trifluoroacetate salt)
- Synonyms
- PPACK II diTFA;JVMDQRDDGVKUMG-WOSURGFKSA-N
- CBNumber:
- CB93152718
- Molecular Formula:
- C27H34ClF3N6O5
- Molecular Weight:
- 615.05
- MDL Number:
- MFCD31720408
- MOL File:
- 649748-23-2.mol
PPACKII (trifluoroacetate salt) price More Price(13)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 5.08573 | InSolution PPACK II, 2TFA - CAS 649748-23-2 - Calbiochem | 649748-23-2 | 5mg | $186 | 2023-01-07 | Buy |
Cayman Chemical | 15360 | PPACKII (trifluoroacetate salt) ≥95% | 649748-23-2 | 1mg | $37 | 2024-03-01 | Buy |
Cayman Chemical | 15360 | PPACKII (trifluoroacetate salt) ≥95% | 649748-23-2 | 5mg | $151 | 2024-03-01 | Buy |
Cayman Chemical | 15360 | PPACKII (trifluoroacetate salt) ≥95% | 649748-23-2 | 10mg | $266 | 2024-03-01 | Buy |
Cayman Chemical | 15360 | PPACKII (trifluoroacetate salt) ≥95% | 649748-23-2 | 25mg | $618 | 2024-03-01 | Buy |
PPACKII (trifluoroacetate salt) Chemical Properties,Uses,Production
Uses
Potent and specific irreversible inhibitor of plasma and glandular kallikreins.
Biological Activity
ppackii is a specific and irreversible inhibitor of glandular and plasma kallikreins [1].human tissue kallikreins (hks) are a class of secreted serine proteases that involved in the release of vasodepressor peptides or kinins from a plasma substrate. kallikrein has diverse expression patterns and physiological roles. kallikrein has been primarily known as cancer biomarkers. kallikrein has been implicated in many cancer-related processes, such as cell-growth regulation, angiogenesis, invasion and metastasis. kallikrein could promote or inhibit neoplastic progression individually and/or with the interaction in cascades with other hks and proteases [2].ppackii prevented apolipoprotein proteolysis in dextran sulfate-precipitated human plasma ldl and inhibited serum atrial natriuretic peptide cleavage at micromolar concentrations [1]. it has been reported that ppackii inactivated the amidolytic activity of native human hageman factor (factor xii) at 5.3 μm [3].
References
[1]. byrne r e, scanu a m. apolipoprotein b-100 of plasma low density lipoproteins undergoes proteolysis by contact activation factors when plasma is treated with dextran sulfate-500-mgcl2[j]. journal of lipid research, 1989, 30(1): 109-120.
[2]. borgoo c a, diamandis e p. the emerging roles of human tissue kallikreins in cancer[j]. nature reviews cancer, 2004, 4(11): 876-890.
[3]. silverberg m, kaplan a p. enzymatic activities of activated and zymogen forms of human hageman factor (factor xii)[j]. blood, 1982, 60(1): 64-70.
PPACKII (trifluoroacetate salt) Preparation Products And Raw materials
Raw materials
Preparation Products
PPACKII (trifluoroacetate salt) Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hangzhou Peptidego Biotech Co.,Ltd. | 0571-87213919 | eric@peptidego.com | China | 6526 | 58 |
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
Hangzhou Sinoda Pharmaceutical Technology Co. LTD | 0571-87213919 17306812703 | 3007955328@qq.com | China | 6213 | 58 |
Nanjing Tengyi Biotechnology Co., Ltd | 025-58851786 17714337195 | sales@tybiochem.com | China | 5586 | 58 |
Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8739 | 58 |
RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9268 | 58 |
ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |