Quininib
- CAS No.
- 143816-42-6
- Chemical Name:
- Quininib
- Synonyms
- Quininib;Quininib >=98% (HPLC);(E)-2-(2-(quinolin-2-yl)vinyl)phenol;2-[(1E)-2-(2-quinolinyl)ethenyl]-phenol;Phenol, 2-[(1E)-2-(2-quinolinyl)ethenyl]-
- CBNumber:
- CB93152723
- Molecular Formula:
- C17H13NO
- Molecular Weight:
- 247.29
- MDL Number:
- MFCD00186931
- MOL File:
- 143816-42-6.mol
Quininib price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 19838 | Quininib | 143816-42-6 | 500μg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 19838 | Quininib | 143816-42-6 | 1mg | $61 | 2024-03-01 | Buy |
| Cayman Chemical | 19838 | Quininib | 143816-42-6 | 5mg | $243 | 2024-03-01 | Buy |
| Cayman Chemical | 19838 | Quininib | 143816-42-6 | 10mg | $426 | 2024-03-01 | Buy |
| TRC | Q694403 | Quininib | 143816-42-6 | 5mg | $195 | 2021-12-16 | Buy |
Quininib Chemical Properties,Uses,Production
Description
Quininib is an antagonist of the cysteinyl leukotriene 1 (CysLT1) and CysLT2 receptors (IC50s = 1.4 and 52 μM, respectively). It inhibits tubule formation in HMEC-1 cells when used at concentrations of 3.16 and 10 μM and inhibits sprout formation in isolated mouse aortic rings in an ex vivo model of angiogenesis when used at 10 μM. Quininib (3 μM) decreases angiogenesis in an oxygen-induced retinopathy mouse model of ocular angiogenesis, preventing revascularization when used at concentrations of 0.5 and 3 μM, as well as increasing neovascularization and vascular density when used at 3 μM. It reduces tumor growth and inhibits angiogenesis in an HT-29 colorectal cancer mouse xenograft model when administered at a dose of 50 mg/kg every three days.
Uses
Quininib is a novel regulator of Ocular Angiogenesis, significantly inhibiting angiogenic tubule formation in HMEC-1 cells, angiogenic sprouting in aortic ring explants and retinal revascularisation in OIR mice.
Definition
ChEBI: Quininib is a styrylquinoline that is trans-2-styrylquinoline in which the the phenyl group has been substituted at position 2 by a hydroxy group. It is an anti-angiogenic compound that exerts a dose-dependent antagonism of the cysteinyl leukotriene pathway, preferentially antagonising cysteinyl leukotriene receptor 1. The major species at pH 7.3 It has a role as an angiogenesis inhibitor. It is a styrylquinoline and a member of phenols. It is functionally related to a trans-2-styrylquinoline. It is a conjugate base of a quininib(1+).
Quininib Preparation Products And Raw materials
Raw materials
Preparation Products
Quininib Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4428 | 55 |
| ShangHai Angti Biotechnology Co., Ltd. | 13764913901 | info@angtibio.com | China | 4957 | 55 |
| ATK CHEMICAL COMPANY LIMITED | 3429815786 13301662590 | sales@atkchemical.com | China | 10103 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9707 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
| Changzhou Furuisi Biotechnology Co., Ltd | 0519-85524369 | 3477467573@qq.com | China | 8618 | 58 |