Pravastatin sodium | 81131-70-6

Pravastatin sodium Properties

Melting point	171.2-173 °C
storage temp.	2-8°C
solubility	H₂O: 19 mg/mL
form	powder
color	white
Merck	14,7714
BCS Class	1 (CLogP), 3 (LogP)
Stability	Hygroscopic
CAS DataBase Reference	81131-70-6(CAS DataBase Reference)
NCI Dictionary of Cancer Terms	Pravachol; pravastatin sodium
FDA UNII	3M8608UQ61
NCI Drug Dictionary	Pravachol
Proposition 65 List	Pravastatin sodium

Pharmacokinetic data

Protein binding	Approx 50%
Excreted unchanged in urine	20%
Volume of distribution	0.5(L/kg)
Biological half-life	1.5-2 / Unchanged

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P332+P313-P337+P313-P362-P403+P233-P405-P501
Hazard Codes	F,C
Risk Statements	11-34
Safety Statements	16-26-36/37/39-45
RIDADR	3077
WGK Germany	2
RTECS	QJ7185000
HazardClass	9
PackingGroup	III
HS Code	29329990

Pravastatin sodium price More Price(50)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	P4498	Pravastatin sodium salt hydrate ≥98% (HPLC), powder	81131-70-6	25mg	$92.7	2024-03-01	Buy
Sigma-Aldrich	524403	Pravastatin, Sodium Salt - CAS 81131-70-6 - Calbiochem A water-soluble, competitive 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that potently blocks in vivo cholesterol synthesis (Ki = ~1 nM).	81131-70-6	25mg	$130	2024-03-01	Buy
Sigma-Aldrich	1554206	Pravastatin sodium	81131-70-6	50mg	$474	2024-03-01	Buy
TCI Chemical	P1796	Pravastatin Sodium >98.0%(HPLC)(T)	81131-70-6	100mg	$314	2024-03-01	Buy
TCI Chemical	P1796	Pravastatin Sodium >98.0%(HPLC)(T)	81131-70-6	500mg	$1059	2024-03-01	Buy

Product number	Packaging	Price	Buy
P4498	25mg	$92.7	Buy
524403	25mg	$130	Buy
1554206	50mg	$474	Buy
P1796	100mg	$314	Buy
P1796	500mg	$1059	Buy

Pravastatin sodium Chemical Properties,Uses,Production

Chemical Properties

White Crystalline Powder

Originator

Apo-Pravastatin ,Apotex Inc., Canada

Uses

An HMGCR inhibitor which blocks cholesterol synthesis

Uses

antihyperlipidemic, HMGCoA reductase inhibitor

Uses

Pravastatin sodium is the salt of pravastatin, a ring-opened member of the statin family. Pravastatin is produced biosynthetically from compactin (mevastatin) by a number of microorganisms, notably Absidia, Cunninghamella, Syncephalastrum, Nocardia or Streptomyces. Typically, statins like compactin, lovastatin and simvastatin possess a β-hydroxy lactone ring which is a pro-drug for the readily ring-opened dihydroxyacid generally regarded as the active HMG-CoAreductase inhibitor. Importantly, the free carboxylic acid enables pravastatin to be freely water soluble within biological pH ranges.

Uses

A competitive inhibitor of HMG-CoA reductase. Bioactive metabolite of Mevastatin

Definition

ChEBI: An organic sodium salt that is the sodium salt of pravastatin. A reversible inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA), it is used for lowering cholesterol and preventing cardiovascular disease. It is one of the lower potency statins, but has the advantage of fewer side effects compared with lovastatin and simvastatin.

Manufacturing Process

Pravastatin was isolated as products of enzymatic hydroxylation by some kinds of microorganisms of [1S-[1-α(R*),7β,8β(2S*,4S*)8αβ]]-2methylbutanoic acid 1,2,3,7,8,8a-hexahydro-7-methyl-8-[2-(tetrahydro-4hydroxy-6-oxo-2))-pyran-2-yl)ethyl]-1-naphthalenic lactone (campactin) or their carboxylic acid or their salts (products of animal metabolism of microorganisms from the genera Nocardia, Streptomyces et cetera).
Pravastatin may be preparated by using the microorganisms of genera Nocardia (method 1) and Mortierella (method 2).
Method 1 Cultivation of Nocardia autotrophica subsp. amethystineCells of Nocardia autotrophica subsp. amethystina FERM P-6183 was inoculated from a slant culture by means of a platinum loop into each of twenty 500 ml Erlenmeyer flasks, each containing 100 ml of a culture medium having the following composition: glucose - 1.0%, peptone - 0.2%, meat extract - 0.1%, yeast extract - 0.1%, corn steep liquor 0.3%, tap water balance..
Shaking was then carried out at 26°C and 220 r.p.m. for 2 days, at which time sodium 2-methyl-8-(2-methyl-1-oxobutoxy)-β,δ-dihydroxy(1S-(1-α(βS*,δ-S*),2-α,6-α,8-β(R*),8a-α))-1-1,2,6,7,8,8ahexahydronaphthaleneheptanoate was added to a final concentration of 0.05% w/v. Incubation was continued at 26°C and 220 r.p.m. for a further 5 days.
Preparation of pravastatin
After completion of the cultivation, the reaction mixture was filtered and the pH of the filtrate was adjusted to a value of 3 by the addition of trifluoroacetic acid. The acidified filtrate was then extracted three times, each with 1 liter of ethyl acetate, to give extracts containing a mixture (6-α and 6-β) of (1S-(1α,β- S*,δ-S*),2-α,8-βR*),8a-α))-1-naphthaleneheptanoic acid 1,2,6,7,8,8ahexahydro-2-methyl-8-(2-methyl-1-oxobutoxy)-β,δ,6-trihydroxy.
This extract was then immediately transferred into a 5% w/v aqueous solution of sodium hydrogen carbonate, and the pH of the mixture was adjusted to a value of 7.0 by the addition of 2 N hydrochloric acid. The mixture was then adsorbed on a Diaion HP-20 column. The column was washed with water and then eluted with 50% v/v aqueous acetone to give a fraction containing (1S(1-α,β- S*,δ-S*),2-α,6-α,8-βR*),8a-α))-1-naphthaleneheptanoic acid 1,2,6,7,8,8a-hexahydro-2-methyl-8-(2-methyl-1-oxobutoxy)-β,δ,6-trihydroxy-, monosodium salt (pravastatin). This was freeze-dried, to give 200 mg of pravastatine.
Method 2 Cultivation of Mortierella maculata nov. spec. E-97 [NCAIM(P)F 001266]
A spore suspension was prepared with 5 ml of a 0.9% sodium chloride solution obtained from a 7-10 day old, malt extract-yeast extract agar slant culture of Mortierella maculata nov. spec. E-97 [NCAIM(P)F 001266] strain able to 6-β-hydroxylate compactin and the suspension was used to inoculate 100 ml inoculum medium PI (glucose-50 g, soybean meal-20 g, in 1000 ml tap water) sterilized in a 500 ml Erlenmeyer flask.
5 liters working volume a bioconversion culture medium is prepared (glucose20 g, glycerine-20 g, soybean meal-20 g, peptone-5 g, potassium dihydrogen phosphate-0.5 g, polypropylene glycol 2000-1 g, in 1000 ml tap water); the components of the culture medium are added corresponding to 5 liters. Then it was sterilized for 45 min at 121°C and seeded with 500 ml of the inoculum culture.
Before sterilization the pH of the medium was adjusted to 7.0 value.
The fermentation was carried out at 28°C, with a stirring rate of 400 rpm andwith an aeration rate from bottom direction 60 liters/hour for 4 days. At the 2nd day after the transfer the culture started to foam heavily, which can be decreased by the addition of further polypropylene glycol 2000. The pH reached 6.3-7.5 by the 4th day. The feeding of the sodium 2-methyl-8-(2methyl-1-oxobutoxy)-β,δ-dihydroxy(1S-(1-α(β- S*,δ-S*),2-α,6-α,8-β(R*),8aα))-1-1,2,6,7,8,8a-hexahydronaphthaleneheptanoate substrate is allowed to be started if the pH of the broth is above 6.3.
Preparation of pravastatinAt the 4th day of the fermentation 2.5 g compactin substrate is added in sterile filtered aqueous solution. Calculated for the volume of the broth 0.51.0% glucose was added into the culture depending on the pH in the form of 50% solution sterilized at 121°C for 25 min in parallel with the substrate feeding. After 24 hours the compactin substrate is consumed from the culture (is detected by HPLC) and was converted to pravastatin. By lyophilization of the aqueous residue 1.3 g pravastatin was obtained. The chromatographically pure product was crystallized from a mixture of ethanol and ethyl acetate. Melting point: 170-173°C (decomp.).

brand name

Pravachol (Bristol-Myers Squibb).

Therapeutic Function

Antihyperlipidemic

General Description

A water-soluble, competitive 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that potently blocks in vivo cholesterol synthesis (K_i = ~1 nM). Offers cardioprotection. Also acts as an immunomodulator and an inhibitor of ras p21 isoprenylation.

Biological Activity

Water-soluble, competitive inhibitor of 3-hydroxy-3-methyl coenzyme A (HMG-CoA) reductase. Potently blocks cholesterol synthesis in vivo (K i ~ 1 nM) and displays cardioprotective properties.

Biochem/physiol Actions

Primary TargetAMG-CoA reductase

Clinical Use

HMG CoA reductase inhibitor:

Hypercholesterolaemia

Drug interactions

Potentially hazardous interactions with other drugs
Antibacterials: increased risk of myopathy with daptomycin, fusidic acid (avoid) and telithromycin; concentration increased by clarithromycin and erythromycin.
Antivirals: increased risk of myopathy with atazanavir and boceprevir; concentration possibly increased by darunavir; concentration reduced by efavirenz.
Ciclosporin: increased risk of myopathy.
Colchicine: possible increased risk of myopathy.
Lipid lowering agents: increased risk of myopathy with fibrates, gemfibrozil (avoid) and nicotinic acid.

Metabolism

Pravastatin undergoes extensive hepatic metabolism to a relatively inactive metabolite. About 70% of an oral dose of pravastatin is excreted in the faeces, as unabsorbed drug and via the bile.

storage

Desiccate at RT

References

[1] bolego c, poli a, cignarella a, catapano al, paoletti r. novel statins: pharmacological and clinical results. cardiovasc drugs ther. 2002 may;16(3):251-7.
[2] keidar s, aviram m, maor i, oiknine j, brook jg. pravastatin inhibits cellular cholesterol synthesis and increases low density lipoprotein receptor activity in macrophages: in vitro and in vivo studies. br j clin pharmacol. 1994 dec;38(6):513-9.
[3] menter dg, ramsauer vp, harirforoosh s, chakraborty k, yang p, hsi l, newman ra, krishnan k. differential effects of pravastatin and simvastatin on the growth of tumor cells from different organ sites. plos one. 2011;6(12):e28813.

Pravastatin sodium Preparation Products And Raw materials

Raw materials

Sodium bicarbonate

Preparation Products

Pravastatin sodium Suppliers

Global( 378)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114 +8618959220845	sales@amoychem.com	China	6383	58
HubeiwidelychemicaltechnologyCo.,Ltd	18627774460	faith@widelychemical.com	CHINA	742	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Shanghai Standard Technology Co., Ltd.	18502101150	ft-sales@nature-standard.com	CHINA	1923	58
Shenzhen Excellent Biotech Co., Ltd.	13480692018	ramyan@ex-biotech.com	CHINA	954	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49374	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29811	58

Supplier	Advantage
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
Hubei Jusheng Technology Co.,Ltd.	58
Xiamen AmoyChem Co., Ltd	58
HubeiwidelychemicaltechnologyCo.,Ltd	58
BOC Sciences	58
Shanghai Standard Technology Co., Ltd.	58
Shenzhen Excellent Biotech Co., Ltd.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58

View Lastest Price from Pravastatin sodium manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-19	Pravastatin sodium 81131-70-6	US $40.00-66.00 / mg		99.08%	10g	TargetMol Chemicals Inc.
2024-11-19	Pravastatin sodium 81131-70-6	US $40.00-66.00 / mg		99.08%	10g	TargetMol Chemicals Inc.
2023-02-24	Pravastatin sodium 81131-70-6	US $0.00 / mg	20mg	≥98%(HPLC)	10 g	Shanghai Standard Technology Co., Ltd.

Pravastatin sodium
81131-70-6
US $40.00-66.00 / mg
99.08%
TargetMol Chemicals Inc.

Pravastatin sodium
81131-70-6
US $40.00-66.00 / mg
99.08%
TargetMol Chemicals Inc.

Pravastatin sodium
81131-70-6
US $0.00 / mg
≥98%(HPLC)
Shanghai Standard Technology Co., Ltd.

Pravastatin sodium Spectrum

Pravastatin sodium(81131-70-6)MS

81131-70-6(Pravastatin sodium)Related Search:

Diclofenac sodium Sodium acetate Sodium hydroxide Sodium bicarbonate Sodium formate

Sodium carbonate Sodium gluconate Sodium benzoate Sodium percarbonate Sodium silicate

Sodium chloride Sodium citrate Sodium chlorite Fluvastatin sodium salt ATORVASTATIN SODIUM

8-CHLOROADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT Pravastatin Sodium chlorate

1of4

2-alpha,6-alpha,8-beta(r*),8a-alpha))-* cs-514 Eptastatin 1-Naphthaleneheptanoic acid, 1,2,6,7,8,8a-hexahydro-.beta.,.delta.,6-trihydroxy-2-methyl-8-(2S)-2-methyl-1-oxobutoxy-, monosodium salt, (.beta.R,.delta.R,1S,2S,6S,8S,8aR)- (βr, δr,1s,2s,6s,8s,8ar)-1,2,6,7,8,8a-hexahydro-β, δ,6-trihydroxy-2-methyl-8[(2s)-2-methyl-1-oxobutoxyl]-1-naphthaleneheptanoic acid sodium 1-Naphthaleneheptanoic acid, 1,2,6,7,8,8a-hexahydro-b,d,6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-, monosodium salt, [1S-[1a(bS*,dS*),2a,6a,8b(R*),8aa]]- 1-Naphthaleneheptanoic acid, 1,2,6,7,8,8a-hexahydro-b,d,6-trihydroxy-2-methyl-8-[(2S)-2-methyl-1-oxobutoxy]-, monosodium salt, (bR,dR,1S,2S,6S,8S,8aR)- (9CI) 3b-Hydroxycompactin sodium salt Lipidal Liprevil Oliprevin Prava Pravacol Pravasin Pravasine Selektine Selipran Vasten Paravastatin PravastatinNaC23H35Na07 1-Naphthaleneheptanoicacid Pravastatine Pravastatinesodium Pravastatin Sodium (US Pat 1981) Elisor, Kopostat, Mevalotin, Pravachol, Pravaselect, [1S-[1a(bS,dS),2a,6b,8b(R),8aa]]-1,2,6,7,8,8a-Hexahydro-b,d,6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-1-naphthaleneheptanoic acid monosodium salt Pravastatinsodium,(S) (R,dR,1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-Hexahydro-,d,6-trihydroxy-2-methyl-8-[(2S)-2-methyl-1-oxobutoxy]-1-naphthaleneheptanoic Acid Sodium Salt sodiuM (3R,5R)-3,5-dihydroxy-7-((1S,2S,6S,8S,8aR)-6-hydroxy-2-Methyl-8-(((S)-2-Methylbutanoyl)oxy)-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)heptanoate Pravastatin sodiuM salt hydrate CS-514 Sodium (βR, δR,1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-Hexahydro-β, δ,6-trihydroxy-2-methyl-8[(2S)-2-methyl-1-oxobutoxyl]-1-naphthaleneheptanoic acid sodium hydrate Eptastatin sodium salt hydrate Mevalotin, CS 514, SQ 3100 Pravastatin sodium, >=98% [1S-[1a(bS,dS),2a,6b,8b(R),8aa]]-1,2,6,7,8,8a-Hexahydro-b,d,6-tri ELISOR EPTASTATIN SODIUM (BETA R,DELTA R,1S,2S,6S,8S,8AR)-1,2,6,7,8,8A-HEXAHYDRO-BETA,DELTA,6-TRIHYDROXY-2-METHYL-8-[(2S)-2-METHYL-1-OXOBUTOXY]-1-NAPHTHALENEHEPTANOIC ACID MONOSODIUM SALT (BETAR, DELTAR,1S,2S,6S,8S,8AR)-1,2,6,7,8,8A-HEXAHYDRO-BETA, DELTA,6-TRIHYDROXY-2-METHYL-8[(2S)-2-METHYL-1-OXOBUTOXYL]-1-NAPHTHALENEHEPTANOIC ACID SODIUM (BETA-R,DELTA-R,1S,2S,6S,8S,8AR)-1,2,6,7,8,8A-HEXAHYDRO-BETA,DELTA,6-TRIHYDROXY-2-METHYL-8[(2S)-2-METHYL-1-OXOBUTOXYL]-1-NAPHTHALENEHEPTANOIC ACID NA epastatinsodium lipostat sq31000 utoxy)-beta,delta,6-trihydroxy-,monosodiumsalt,(1s-(1-alpha(beta-s*,delta-s KOPOSTAT MEVALOTIN 3BETA-HYDROXYCOMPACTIN, NA PRAVASTATIN SODIUM SALT PRAVASTATIN SODIUM PRAVASELECT PRAVACHOL Eptastatin sodium salt, (βR, δR,1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-Hexahydro-β, δ,6-trihydroxy-2-methyl-8[(2S)-2-methyl-1-oxobutoxyl]-1-naphthaleneheptanoic acid sodium (betaR,deltaR,1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-Hexahydro-beta,delta,6-trihydroxy-2-methyl-8-[(2S)-2-methyl-1-oxobutoxy]-1-naphthaleneheptanoic acid monosodium salt (1S,βR,δR)-1,2,6,7,8,8aβ-Hexahydro-β,δ,6β-trihydroxy-2β-methyl-8α-[[(S)-2-methyl-1-oxobutyl]oxy]-1β-naphthaleneheptanoic acid sodium salt Pravastatin SodiuM, EP Pravastatin-d3 Pravastatin-d9 (raceMic)